Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$170K - $222K *

Drive strategic transformation initiatives across Product, GTM, and Operations. Lead cross-functional teams, manage complex portfolios, and deliver measurable results while fostering clarity and accou...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Information Technology

$168K - $219K *

Join a dynamic team as a Sr. Solutions Engineer, leveraging your expertise to solve complex business challenges for mid-market customers, driving impactful solutions and fostering collaboration to enh...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Shape the future of enrichment programs by driving strategy, execution, and operational excellence across multiple sites, ensuring impactful experiences for families and children while achieving finan...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$116K - $155K *

Shape the future of HR technology by leading strategy, governance, and optimization of HRIS. Drive operational excellence, enhance user experience, and ensure compliance while managing a high-performi...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$115K - $125K *

Drive the development and enhancement of enterprise planning solutions globally, focusing on Anaplan and supporting FP&A, Sales, and Production Planning initiatives. Collaborate with teams to analyze...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$150K - $180K *

Drive your career forward by leveraging advanced AI to enhance pricing programs. Join a new, dynamic team focused on building evaluations that ensure AI delivers value and accuracy, shaping the future...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$150K - $180K *

Join a dynamic team to lead AI-driven pricing innovations in insurance. Shape strategies, evaluate models, and drive high-value applications to market. Your leadership will empower data scientists and...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$66K - $106K *

Help us ensure software quality by developing and executing automated test scripts, assisting in defect tracking, and supporting adherence to rigorous quality standards within an Agile environment...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$80K - $128K *

Elevate cybersecurity operations by monitoring threats, analyzing network traffic, and coordinating incident responses. Collaborate with teams to enhance security measures and mentor junior analysts w...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$66K - $106K *

Join a dynamic team to design and implement secure identity solutions using Okta, ensuring compliance with DoD standards while enhancing authentication processes across high-visibility systems in a fu...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$80K - $128K *

Elevate your career as a DFIR Analyst, conducting cyber data analytics, leading detection technologies, and enhancing security measures. Collaborate with IT teams to protect assets and support inciden...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$79K - $91K *

Transform healthcare delivery by leading the RN UM Team, ensuring timely care decisions and maintaining documentation quality while fostering a culture of clinical excellence and accountability...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$165K - $210K *

Transform retail sales strategies and lead a dynamic team to achieve revenue goals. Drive account management, develop talent, and collaborate with cross-functional teams to enhance product offerings a...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$108K - $135K *

Join our team as a Telehealth Pharmacist, where you'll enhance member health through Medication Therapy Management and clinical outreach programs, ensuring high-quality care and compliance with indust...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$94K - $179K *

Lead quality initiatives by optimizing test strategies and automation processes. Collaborate with cross-functional teams to ensure high-quality software delivery while mentoring engineers and driving...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$94K - $179K *

Lead the charge in managing complex projects from inception to completion, ensuring timely delivery and stakeholder satisfaction while guiding cross-functional teams through the project lifecycle...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$101K - $204K *

Help us shape compensation strategies that attract and retain top talent. As a Senior Compensation Partner, you'll collaborate with leaders to navigate complex compensation challenges and enhance our...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$92K - $158K *

Optimize security for AWS infrastructure by designing and implementing robust controls. Collaborate with teams to ensure compliance and continuous monitoring while addressing vulnerabilities and enhan...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Business Services

$92K - $158K *

Lead the charge in cybersecurity compliance for an AWS-hosted Army application, managing vulnerability findings and security scanning while collaborating with technical teams to ensure robust security...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Business Services

$120K - $145K *

Empower federal clients by architecting innovative ServiceNow solutions that enhance IT modernization. Lead design, integration, and release management while mentoring teams to deliver scalable, secur...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Lead the charge in designing and deploying ServiceNow solutions for federal clients. Oversee complex builds, mentor developers, and ensure compliance with federal IT standards while maintaining upgrad...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $110K *

Join a dynamic team to build and modernize federal applications using JavaScript, React, and AWS. This role offers growth into full-stack development, focusing on creating secure, accessible user inte...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$160K - $195K *

Engage with healthcare payer clients to architect integrated solutions, driving revenue growth through strategic discovery, technical leadership, and value engineering. Collaborate across teams to del...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Healthcare

$110K - $130K *

Drive seamless API integrations across systems, enhancing data flow and interoperability. Collaborate with cross-functional teams to optimize performance and scalability, ensuring efficient delivery o...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Take ownership of complex facility transitions by developing and coordinating detailed relocation plans. Collaborate across departments to ensure seamless execution of moves, managing timelines, resou...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.