Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$235K - $275K *

Advance your career by driving perception innovation in autonomous systems. Lead a team focusing on scene detection, environmental robustness, and scalable architectures. Collaborate on cutting-edge t...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Transportation

$250K - $300K *

Join a dedicated team to provide comprehensive medical care, ensuring patient safety and health education while collaborating with healthcare professionals to enhance patient outcomes and maintain hig...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $195K *

Join a dynamic team as you cultivate investor relationships and drive capital growth. Leverage your LIHTC expertise to expand our investor base, manage key accounts, and contribute to impactful afford...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$90K - $95K *

Champion the analysis of Low-Income Housing Tax Credit projects, leveraging strong financial acumen to prepare investment models and reports. Collaborate with developers and manage multiple assignment...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$199K - $370K *

Optimize your sales expertise by driving revenue in state government sectors. Leverage your knowledge of procurement processes to build relationships and close deals, while collaborating with a top-ti...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Media

$199K - $370K *

Engage with high-value government accounts nationwide, driving sales of industry-leading cloud solutions. Leverage your expertise in government procurement to build relationships, exceed quotas, and c...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Media

$150K - $279K *

Transform local government sales by proactively building relationships, generating pipeline, and driving revenue through innovative cloud solutions. Collaborate with a world-class sales team to exceed...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Media

$199K - $370K *

Build strategic partnerships that drive growth and market success. Oversee the full lifecycle of partnerships, from sourcing and negotiation to execution and performance monitoring, ensuring alignment...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Media

$199K - $370K *

Lead a dynamic team of Sales Specialists to drive growth and revenue in the Risk sector. Collaborate with leadership to enhance customer engagement, implement strategic solutions, and achieve sales ta...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Media

$80K - $95K *

Drive customer success by managing key accounts in cattle genomics. Collaborate with cross-functional teams to enhance service delivery, support genomic solutions, and ensure high-quality customer exp...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$101K - $156K *

Elevate your career by configuring and enhancing Workday HCM solutions, driving user-centered processes and collaborating with stakeholders to deliver scalable, compliant solutions that support organi...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Elevate energy commercialization by leading origination strategies for hydroelectric products. Develop key relationships, negotiate contracts, and enhance revenue certainty while navigating market dyn...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Energy & Utilities

$120K - $145K *

Join a team that's redefining pricing strategies and business analysis. As a key member, you'll develop competitive pricing models, analyze risks, and collaborate with finance and business development...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Staffing

$110K - $150K *

Take ownership of the SAP Concur platform, ensuring efficient travel and expense processes. Collaborate with cross-functional teams to enhance system functionality, resolve issues, and support complia...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$80K - $95K *

Empower a team of Partnerships Directors by coaching and developing their sales skills, creating effective sales practices, and leveraging data to drive performance. This role blends teaching and mana...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$125K - $135K *

Take ownership of features from design to production, enhance system reliability, and collaborate closely with engineers, product, and design teams to solve complex technical challenges in a dynamic e...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$119K - $172K *

Innovate the future of technical talent acquisition by leading high-stakes searches for senior engineers, data specialists, and product leaders. Shape strategies, elevate standards, and leverage AI to...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$160K - $170K *

Join a team that designs scalable and secure technology solutions by collaborating with various stakeholders. You'll lead architecture efforts for enterprise-level projects and shape our Enterprise Ar...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Transportation

$208K - $250K *

Transform the customer experience by leading the OpenTelemetry journey, creating cohesive strategies for seamless telemetry integration and ensuring product success through effective cross-functional...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$62K - $127K *

Join a team that's dedicated to delivering exceptional customer service while managing complex general liability claims. Collaborate with legal partners to develop strategies for effective resolution...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$95K - $115K *

Drive advanced support for traffic signal controller systems, ensuring reliable performance through troubleshooting and integration. Collaborate with teams to resolve issues and enhance operational ef...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Transportation

$112K - $162K *

Play a key role in managing large partnerships, driving pricing strategy and inventory decisions while fostering commercial health and mentoring junior traders in a dynamic pricing environment...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$171K - $248K *

Elevate fan support through innovative technology and collaborative leadership. As a technical manager, drive the vision and execution for a best-in-class support experience, empowering your team to e...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$120K - $300K *

Transform enterprise sales by driving innovative messaging solutions and closing six-figure deals. Leverage your expertise to engage top brands, manage the sales cycle, and foster strong relationships...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Media

$89K - $115K *

Manage comprehensive clinical reviews of disability claims, collaborating with stakeholders to assess medical evidence and functional impact. Provide expert recommendations and support timely evaluati...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.