Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$60K - $125K *
Empower customer success by managing relationships and driving growth through strategic account management, ensuring satisfaction and advancing CloudWave as a trusted IT advisor in healthcare solution...
2 days ago
Sr Life Underwriting Business Systems Analyst
$85K - $100K *
Champion life underwriting transformation initiatives by analyzing requirements, facilitating project lifecycles, and collaborating with cross-functional teams to enhance operational excellence and im...
2 days ago
Digital Solutions Integration Engineer III
$110K - $130K *
Join a dynamic team to design and support advanced Active Network Management Systems, leading their lifecycle from development to commissioning while ensuring integration with external systems and del...
2 days ago
$119K - $149K *
Engage in strategic financial planning and analysis, overseeing projects and guiding investment decisions. Lead a team to ensure milestones are met while fostering a collaborative environment for grow...
2 days ago
Regional Sales Manager - Northwest
$80K - $100K *
Unlock potential by driving sales growth in a dynamic territory, cultivating relationships with diverse clients, and leveraging technical expertise to deliver effective packaging solutions that surpas...
Reposted 2 days ago
Senior Principal - AI and Data CRL, Infosys Consulting
$210K - $256K *
Transform industry practices by leading large-scale AI and data initiatives, driving business growth and operational excellence within Consumer Products, Retail, and Logistics sectors...
Reposted 2 days ago
$125K - $225K *
Create innovative data solutions by designing scalable pipelines and AI tools. Collaborate with cross-functional teams to enhance data quality and security, driving impactful analytics and machine lea...
2 days ago
Senior Program Manager/Engineering Manager
$125K - $225K *
Lead the charge in multidisciplinary engineering and design management for a large-scale industrial infrastructure project, ensuring compliance with technical standards and client expectations through...
2 days ago
Account Manager - Beverage and Frozen Dessert Ingredients
$90K - $110K *
Transform the beverage and dessert ingredient landscape by driving sales growth, expanding market presence, and fostering strong customer relationships. Collaborate with cross-functional teams to deli...
2 days ago
Senior Program Manager - Data Security & Information Governance
$135K - $178K *
Transform data governance by leading initiatives that bridge legal compliance, data security, and technology operations. Drive innovative self-service workflows while ensuring compliance across divers...
Reposted 2 days ago
$114K - $210K *
Champion regulatory document development for global submissions, ensuring compliance with ICH guidelines and corporate objectives. Lead projects, mentor junior staff, and enhance cross-functional coll...
2 days ago
$73K - $110K *
Champion compliance excellence by managing HR programs, ensuring alignment with laws, and enhancing processes. Collaborate across teams to minimize risk and support organizational growth while navigat...
2 days ago
Senior Program Manager I - RCCA Program Manager
$100K - $120K *
Unlock potential by leading complex subrecipient programs, ensuring compliance, and fostering collaboration across teams to drive impactful opioid response initiatives in Illinois. This role demands s...
2 days ago
$198K - $233K *
Shape AI product strategy by synthesizing trends, customer needs, and tech capabilities. Collaborate with engineering and design to drive innovation, enabling AI solutions that deliver genuine custome...
2 days ago
Senior Manager Stock Plan Participant Services
$96K - $135K *
Champion exceptional participant experiences by leading a dynamic team in equity compensation services. Drive operational excellence, ensure compliance, and enhance service delivery while fostering te...
2 days ago
$80K - $95K *
Build relationships with personal injury attorneys to drive referrals for settlement planning and wealth management. Leverage your expertise to develop sales strategies and enhance brand awareness whi...
2 days ago
$79K - $127K *
Unlock insights into medical cost trends by leveraging data analytics. Collaborate with cross-functional teams to develop strategic recommendations, track program outcomes, and present findings clearl...
2 days ago
Director - Product Management, LATAM
$163K - $297K *
Join a dynamic team to shape the future of digital consumer experiences in LATAM. Lead product strategy and execution for innovative e-commerce solutions, driving customer satisfaction and loyalty whi...
2 days ago
Product Owner - Digital Banking Experience
$80K - $95K *
Unlock potential by leading the digital banking strategy and execution. Collaborate across teams to enhance customer experiences, drive operational efficiency, and support business growth through inno...
2 days ago
$88K - $105K *
Lead product marketing initiatives by crafting compelling messaging and strategies that drive customer engagement and adoption. Collaborate cross-functionally to ensure alignment and measure performan...
2 days ago
Territory Sales Manager, Retail, Grocery, Food Service, & Cold Chain (Western US)
$90K - $110K *
Accelerate progress at driving revenue growth and expanding customer relationships through innovative supply chain solutions. Leverage consultative sales skills to identify opportunities and build las...
2 days ago
Cyber Risk and Compliance Specialist
$95K - $115K *
Unlock potential by leading IT SOX compliance and enhancing global security culture. Balance technical auditing with advocacy, ensuring financial integrity and regulatory adherence while fostering a r...
Reposted 2 days ago
$183K - $220K *
Lead strategic initiatives for Integrated Delivery Networks and health systems, optimizing patient access and formulary adoption. Build executive relationships and drive clinical integration to enhanc...
2 days ago
$160K - $175K *
Elevate platform reliability by designing and evolving cloud infrastructure, CI/CD pipelines, and Kubernetes environments. Collaborate across teams to enhance software delivery, operational excellence...
2 days ago
Specialist, Product Management (MTSS)
$75K - $90K *
Lead the charge in expanding our MTSS product roadmap, guiding development and commercialization efforts. Collaborate with educators and cross-functional teams to enhance assessment tools that support...
2 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.