Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$60K - $125K *

Empower customer success by managing relationships and driving growth through strategic account management, ensuring satisfaction and advancing CloudWave as a trusted IT advisor in healthcare solution...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $100K *

Champion life underwriting transformation initiatives by analyzing requirements, facilitating project lifecycles, and collaborating with cross-functional teams to enhance operational excellence and im...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Join a dynamic team to design and support advanced Active Network Management Systems, leading their lifecycle from development to commissioning while ensuring integration with external systems and del...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$119K - $149K *

Engage in strategic financial planning and analysis, overseeing projects and guiding investment decisions. Lead a team to ensure milestones are met while fostering a collaborative environment for grow...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$80K - $100K *

Unlock potential by driving sales growth in a dynamic territory, cultivating relationships with diverse clients, and leveraging technical expertise to deliver effective packaging solutions that surpas...

RemoteRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$210K - $256K *

Transform industry practices by leading large-scale AI and data initiatives, driving business growth and operational excellence within Consumer Products, Retail, and Logistics sectors...

United StatesRemote

Reposted 2 days ago

  •   11 - 15 years exp.  •   Information Technology

$125K - $225K *

Create innovative data solutions by designing scalable pipelines and AI tools. Collaborate with cross-functional teams to enhance data quality and security, driving impactful analytics and machine lea...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$125K - $225K *

Lead the charge in multidisciplinary engineering and design management for a large-scale industrial infrastructure project, ensuring compliance with technical standards and client expectations through...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$90K - $110K *

Transform the beverage and dessert ingredient landscape by driving sales growth, expanding market presence, and fostering strong customer relationships. Collaborate with cross-functional teams to deli...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Business Services

$135K - $178K *

Transform data governance by leading initiatives that bridge legal compliance, data security, and technology operations. Drive innovative self-service workflows while ensuring compliance across divers...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Information Technology

$114K - $210K *

Champion regulatory document development for global submissions, ensuring compliance with ICH guidelines and corporate objectives. Lead projects, mentor junior staff, and enhance cross-functional coll...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$73K - $110K *

Champion compliance excellence by managing HR programs, ensuring alignment with laws, and enhancing processes. Collaborate across teams to minimize risk and support organizational growth while navigat...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$100K - $120K *

Unlock potential by leading complex subrecipient programs, ensuring compliance, and fostering collaboration across teams to drive impactful opioid response initiatives in Illinois. This role demands s...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$198K - $233K *

Shape AI product strategy by synthesizing trends, customer needs, and tech capabilities. Collaborate with engineering and design to drive innovation, enabling AI solutions that deliver genuine custome...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$96K - $135K *

Champion exceptional participant experiences by leading a dynamic team in equity compensation services. Drive operational excellence, ensure compliance, and enhance service delivery while fostering te...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Build relationships with personal injury attorneys to drive referrals for settlement planning and wealth management. Leverage your expertise to develop sales strategies and enhance brand awareness whi...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$79K - $127K *

Unlock insights into medical cost trends by leveraging data analytics. Collaborate with cross-functional teams to develop strategic recommendations, track program outcomes, and present findings clearl...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$163K - $297K *

Join a dynamic team to shape the future of digital consumer experiences in LATAM. Lead product strategy and execution for innovative e-commerce solutions, driving customer satisfaction and loyalty whi...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Unlock potential by leading the digital banking strategy and execution. Collaborate across teams to enhance customer experiences, drive operational efficiency, and support business growth through inno...

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$88K - $105K *

Lead product marketing initiatives by crafting compelling messaging and strategies that drive customer engagement and adoption. Collaborate cross-functionally to ensure alignment and measure performan...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$90K - $110K *

Accelerate progress at driving revenue growth and expanding customer relationships through innovative supply chain solutions. Leverage consultative sales skills to identify opportunities and build las...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Unlock potential by leading IT SOX compliance and enhancing global security culture. Balance technical auditing with advocacy, ensuring financial integrity and regulatory adherence while fostering a r...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Healthcare

$183K - $220K *

Lead strategic initiatives for Integrated Delivery Networks and health systems, optimizing patient access and formulary adoption. Build executive relationships and drive clinical integration to enhanc...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$160K - $175K *

Elevate platform reliability by designing and evolving cloud infrastructure, CI/CD pipelines, and Kubernetes environments. Collaborate across teams to enhance software delivery, operational excellence...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Transportation

$75K - $90K *

Lead the charge in expanding our MTSS product roadmap, guiding development and commercialization efforts. Collaborate with educators and cross-functional teams to enhance assessment tools that support...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.