Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$140K - $270K *

Unlock potential by designing and deploying scalable AI systems that transform healthcare workflows. Collaborate with cross-functional teams to solve complex business challenges and drive measurable o...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$105K - $155K *

Unlock potential by leading the strategy for consumption-based pricing. Drive the execution of innovative pricing models and processes, collaborating with cross-functional teams to enhance customer ex...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$179K - $249K *

Lead the charge in shaping and executing the Operational Risk program, collaborating with key teams to enhance risk management practices and reporting as the organization transitions to banking operat...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$90K - $120K *

Elevate brand presence through in-store execution, relationship-building, and training. Drive sales support and visual merchandising while collaborating with key accounts to enhance customer experienc...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$242K - $275K *

Lead and elevate the Database Platform team, driving data architecture, reliability, and team culture for scalable data solutions. Collaborate cross-functionally to ensure data integrity and operation...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$115K - $194K *

Lead a dynamic Support Engineering team, enhancing customer experiences through AI-driven solutions, mentorship, and scalable processes while fostering a culture of growth and accountability...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $225K *

Champion NEPA/PD&E projects by leading teams, managing budgets, and driving client relationships. Leverage extensive experience in highway/bridge sectors to deliver innovative solutions and ensure pro...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$80K - $95K *

Lead the charge in managing a complex portfolio of higher education accounts, focusing on strategic retention and growth. Collaborate with cross-functional teams to drive renewal success and identify...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$88K - $154K *

Unlock potential by administering project-level IT systems, managing access, ensuring data security, and coordinating with client IT teams to support project success and compliance across multiple ini...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$110K - $130K *

Empower customer success by managing strategic accounts, driving growth, and ensuring satisfaction. Build relationships, analyze data, and collaborate cross-functionally to exceed goals and mitigate r...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $195K *

Elevate client relationships by managing key accounts, driving satisfaction and growth. Collaborate with internal teams to deliver tailored solutions, ensuring long-term success and measurable ROI for...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$176K - $327K *

Unlock potential by leading product marketing strategies for a cutting-edge data platform. Collaborate with cross-functional teams to create compelling content that simplifies complex technology, driv...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Join a team that's redefining scientific data management in drug discovery. Lead the scientific data team, bridging scientists and engineers to ensure data integrity, quality, and innovative solutions...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$85K - $100K *

Join us to empower senior leaders by managing complex projects, client contracts, and travel arrangements. Your proactive support will enhance team efficiency in a fully virtual environment, fostering...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$110K - $130K *

Elevate client success by managing complex projects, ensuring timely delivery, and maintaining budget integrity. Collaborate with diverse teams to drive engagement and optimize project outcomes from i...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$190K - $210K *

Champion data-driven strategies by leading GTM analytics and applied AI initiatives. Collaborate with Sales or Marketing leadership to optimize performance, drive impactful insights, and build innovat...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$65K - $123K *

Champion premium software support for mainframe clients, focusing on CICS and WAS. Drive installations, testing, and maintenance of systems software while ensuring timely customer service and effectiv...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Join a dynamic team to enhance website performance and user experience through innovative SEO strategies, technical audits, and content optimization, driving organic visibility and business results on...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Unlock the potential of fintech analytics by evaluating deal economics, monitoring profitability, and supporting forecasting across diverse financial verticals. Collaborate with cross-functional teams...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$79K - $127K *

Shape excellence by leading service project delivery and fostering customer satisfaction. This dynamic role demands robust management skills in the North American mining and material market, ensuring...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$119K - $142K *

Join a team that's redefining digital operations by leading strategic initiatives, enhancing customer experiences, and driving growth in a fast-paced environment. Shape the future of MODAL Digital whi...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$107K - $147K *

Unlock potential by ensuring accurate and timely external financial reporting. Collaborate with cross-functional teams to enhance compliance and operational efficiency while driving continuous improve...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$148K - $178K *

Transform municipal services by leading complex projects and optimizing the Accela Civic Platform. Drive innovation in permitting and development processes while ensuring compliance and enhancing cust...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$72K - $121K *

Join a team that's dedicated to promoting compliance while leading project initiatives. Collaborate across departments as a functional expert to establish policies and monitor compliance with regulato...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$76K - $95K *

Join a team that's at the forefront of semiconductor technology, providing hands-on support and troubleshooting for advanced ZEISS systems. Collaborate with customers and teams to enhance service qual...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.