Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$75K - $100K *

Help us build lasting relationships with local businesses while providing tailored solutions. This role offers autonomy, teamwork, and personal growth opportunities in a supportive, high-performance c...

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$145K - $185K *

Join a team that's driving marketing excellence by owning and scaling our marketing operations. You'll lead cross-functional projects, optimize tech stacks, and ensure data integrity to enhance pipeli...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$115K - $140K *

Join a team that's dedicated to transforming patient engagement through innovative marketing strategies. You'll develop and execute multichannel campaigns, crafting compelling content that drives enro...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$170K - $250K *

Help us build a high-performing infrastructure team that drives operational excellence and reliability. Lead a diverse group of engineers, manage budgets, and modernize technology while collaborating...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$95K - $160K *

Elevate People Technology by optimizing systems and processes, ensuring data integrity, and enhancing user experiences. Collaborate with cross-functional teams to drive efficiency and support a fast-p...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Drive healthcare transformation by leading advanced consulting initiatives, enhancing delivery systems, and improving health outcomes. Collaborate with clients and stakeholders to implement strategic...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$125K - $150K *

Engage with policymakers and business leaders to drive revenue opportunities. Shape go-to-market strategies and government affairs initiatives, connecting teams to leverage policy insights for impactf...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$117K - $147K *

Lead the charge in shaping product marketing strategies that drive growth and market differentiation. Collaborate with cross-functional teams to execute go-to-market initiatives and influence product...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $100K *

Drive your career forward by managing the full recruiting lifecycle, collaborating with leadership to identify talent needs, and shaping a high-performing team that aligns with our mission and culture...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Transportation

$127K - $165K *

Lead strategic initiatives that drive growth and operational efficiency across teams. Collaborate with executives to shape the company's trajectory, identify new opportunities, and implement innovativ...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$98K - $187K *

Lead the charge in transforming financial services by driving enterprise sales of a cutting-edge SaaS platform. Collaborate with top-tier clients to enhance customer experiences and achieve strategic...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$140K - $190K *

Lead the charge in driving business excellence initiatives across Global Patient Safety. Collaborate with cross-functional teams to enhance project management, governance, and operational effectivenes...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$76K - $102K *

Engage in a dynamic role driving client acquisition in the Home-Based Care sector. You'll build a robust pipeline, execute sales strategies, and collaborate cross-functionally to enhance client experi...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$132K - $193K *

Drive data excellence as an Epic-certified Clarity/Caboodle Administrator, ensuring optimal database performance and reliable ETL operations in a hospital environment. Collaborate with teams to enhanc...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$154K - $204K *

Champion strategic financial planning and analysis, driving enterprise-wide initiatives and insights. Lead a high-performing team, enhance reporting capabilities, and support executive decision-making...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Finance & Insurance

$100K - $120K *

Drive customer success by engaging in pre and post-sales technical support, showcasing innovative radar solutions, and fostering strong relationships. Collaborate with teams to enhance product offerin...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Lead the development of innovative Provider Onboarding solutions, architecting robust systems and mentoring engineers to enhance mental healthcare access. Drive product implementations and build scala...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$160K - $200K *

Drive the M&A strategy by leading the full transaction lifecycle, from sourcing to integration. Collaborate with executive leadership to identify growth opportunities that enhance enterprise value and...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $100K *

Champion client success by managing relationships with family law firms. Drive strategic conversations, align business goals, and leverage insights to enhance growth and performance across your portfo...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$125K - $150K *

Oversee a portfolio of clinical studies, ensuring compliance and quality. Lead Project Managers in executing complex trials, driving operational efficiency and client satisfaction while leveraging you...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$124K - $171K *

Champion advanced machine learning techniques to develop multimodal AI systems in biomedical applications, collaborating with cross-functional teams to enhance personalized oncology diagnostics and im...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Champion seamless communication by managing VoIP and telephony systems, ensuring optimal performance and user satisfaction. Collaborate across departments to analyze data, enhance workflows, and uphol...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $155K *

Drive product growth through data analysis and experimentation, collaborating with cross-functional teams to enhance user adoption and engagement. Utilize statistical methods to illuminate user journe...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $120K *

Accelerate product development by leading end-to-end processes, integrating advanced technologies, and driving outcomes across a suite of digital solutions for legal service operations, while ensuring...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$105K - $115K *

Optimize medical device utilization in health systems by leveraging expertise in cardiovascular, interventional radiology, and general surgery. Collaborate with stakeholders to drive cost reduction an...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.