Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Institutional Business Manager - North Los Angeles
$110K - $130K *
Join a team that's dedicated to transforming patient care by executing strategic business plans and driving sales initiatives across a broad geographical region. Develop relationships with healthcare...
Reposted 2 weeks ago
$104K - $145K *
Join us to lead a dynamic team managing consumer complaints in lending operations. You'll enhance complaint resolution processes, ensure regulatory compliance, and drive continuous improvement, all wh...
2 weeks ago
Senior Partner Marketing Manager
$110K - $130K *
Engage with top-tier partners to define and execute innovative co-marketing strategies that amplify AI-driven growth. Oversee the entire partner marketing roadmap, ensuring measurable impact on pipeli...
Reposted 2 weeks ago
Senior Manager, Energy Development
$190K - $215K *
Champion the future of energy development by leading regional strategies, managing utility relationships, and driving contract negotiations. This role balances strategic oversight with tactical execut...
2 weeks ago
$225K - $250K *
Join us to lead the strategic growth of our data feeds portfolio, driving performance and innovation. Collaborate across teams to shape market strategies, enhance client value, and establish a scalabl...
2 weeks ago
Regional Medical Director, 24/7 Care
$230K - $240K *
Inspire excellence by leading provider support initiatives, enhancing satisfaction, accountability, and clinical quality. Drive process innovation and mentorship in a dynamic environment, ensuring com...
2 weeks ago
Founding Data & Machine Learning Lead
$140K *
Join a team that's redefining data strategy and engineering. In this hands-on role, you'll build and optimize data infrastructure, develop predictive models, and collaborate with cross-functional team...
2 weeks ago
Staff Engineer - QA Automation
$110K - $130K *
Shape the future of quality assurance by leading automated testing initiatives for cloud-based ERP systems, ensuring seamless integration and performance across various business processes and upgrades...
2 weeks ago
Senior Account Executive, LE/GE, GTS
$132K - $170K *
Unlock client growth opportunities through strategic relationships, driving value in a fast-paced B2B sales environment. Collaborate with C-Level Executives across diverse sectors to ensure client sat...
Reposted 2 weeks ago
$140K - $175K *
Join a team that's redefining partner management by owning high-value relationships, driving growth through strategic planning, and collaborating across departments to enhance customer outcomes and re...
2 weeks ago
Head of Business Development, IDD & Behavioral Health
$200K - $270K *
Accelerate progress at multi-state market development by building key relationships, navigating complex contracting processes, and driving approvals in Medicaid and managed care environments. Own the...
2 weeks ago
Business Development Manager (CTS Database)
$100K - $120K *
Shape the future of clinical trials by driving business development initiatives, identifying opportunities with sponsors and CROs, and promoting CTSdatabase's services to enhance growth and profitabil...
2 weeks ago
$240K - $330K *
Transform the GTM Systems landscape by leading strategy, architecture, and operations. Drive efficiency across Sales, Marketing, and Customer Success through innovative solutions and data governance...
2 weeks ago
Senior Windows Engineer - Managed Services
$106K - $150K *
Unlock potential by providing expert operational support for Windows environments. Manage complex incidents, ensure service availability, and collaborate across teams to enhance customer experiences i...
2 weeks ago
California Collaborating Psychiatrist (Clinical & Supervisory Role)
$210K - $250K *
Join a dynamic mental health team as a Collaborating Psychiatrist, providing clinical oversight and direct patient care. Engage in meaningful collaboration with PMHNPs while ensuring compliance and de...
2 weeks ago
Program Evaluator - State & Local Outcomes (Human Services / BH / Justice)
$80K - $95K *
Analyze and lead evaluations for human-services and public programs, creating frameworks and performance measures. Collaborate with stakeholders to translate findings into actionable insights, ensurin...
2 weeks ago
$100K - $120K *
Lead the charge in tax management by preparing and reviewing complex returns, guiding a skilled team, and delivering exceptional client service while assuming responsibility for a diverse range of tax...
Reposted 2 weeks ago
$95K - $130K *
Lead the charge in optimizing paid search strategies, managing a $700K-$1M monthly budget, and driving growth across multiple platforms. Own end-to-end account management, from keyword strategy to off...
2 weeks ago
Adult Nutrition Acute Care Specialist - Dallas-Fort Worth
$61K - $122K *
Join a team that's driving impactful sales strategies for leading nutrition brands. You will engage with healthcare professionals and expand market share through clinical insights and strong relations...
Reposted 2 weeks ago
Informatics Lead, Clinical Intelligence
$117K - $161K *
Drive impactful clinical intelligence initiatives by analyzing AI opportunities, conducting feasibility studies, and collaborating with cross-functional teams to enhance patient care and operational e...
2 weeks ago
Medical Director, Virtual Urgent Care & On-Demand Telehealth (Build & Scale 24/7 Service)
$335K - $387K *
Shape the future of virtual care by leading a dynamic clinical team, enhancing patient access, and driving innovative health solutions. This role combines clinical leadership with operational excellen...
2 weeks ago
Managed Care Pharmacist - Managed Care/PBM
$110K - $130K *
Transform pharmacy outcomes by leading managed care initiatives that optimize clinical programs, enhance stakeholder collaboration, and drive cost efficiencies in pharmacy benefit management...
Reposted 2 weeks ago
SAG Workout Officer III-Remote
$96K - $207K *
Lead the charge in managing complex credit liquidations and rehabilitations. Collaborate with Portfolio Managers to optimize returns while ensuring compliance and risk management, fostering a positive...
2 weeks ago
IA Territory Sales Manager (Arkansas and Oklahoma)
$97K - $151K *
Unlock potential by managing agency relationships and driving sales growth in assigned territories. Utilize training, data analysis, and strategic initiatives to enhance performance and engagement, en...
2 weeks ago
Senior Director Software Engineering
$286K - $326K *
Champion engineering excellence by leading high-performing teams to innovate scalable, customer-centric solutions. Drive technical strategy and architecture while fostering a culture of continuous lea...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.