Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Sys SVP Financial Planning and Analysis
$210K - $250K *
Drive strategic financial planning and analysis to optimize resource allocation, support executive decision-making, and enhance operational performance across the organization, ensuring alignment with...
2 weeks ago
Senior Associate, Market Intelligence
$80K - $95K *
Optimize market intelligence within global diagnostics by leading analytical work, synthesizing data, and translating complex insights into actionable recommendations. Collaborate with diverse stakeho...
2 weeks ago
Senior Consultant - State Government IT IV&V
$90K - $130K *
Pioneer innovative solutions for state government clients by leading IV&V projects, providing expert guidance on system implementations, and ensuring project success through effective communication an...
2 weeks ago
$110K - $125K *
Lead and develop a high-performing Solution Consulting team, driving strategic engagements and delivering impactful product demonstrations to agency and brokerage clients. Collaborate cross-functional...
2 weeks ago
Director, Data Strategy & Analytics
$150K - $180K *
Drive impactful data strategies and analytics by leading a high-performing team, optimizing decision-making, and enhancing operational efficiency across the organization. Collaborate with stakeholders...
2 weeks ago
Behavioral Health Virtual Preceptor - Nurse Practitioner or Physician Assistant
$100K - $120K *
Unlock potential by mentoring new providers through virtual education, ensuring a seamless onboarding experience. Leverage your clinical expertise to foster growth in both primary care and behavioral...
2 weeks ago
$78K - $140K *
Grow your career with an energetic sales force driving success in State and Local Government accounts. Engage with customers, enhance relationships, and boost revenue while achieving personal and team...
Reposted 2 weeks ago
Clinical Solutions Specialist, Ambulatory Surgery Centers (ASC)- Midwest
$76K - $114K *
Shape the future of healthcare by driving growth in Electrophysiology-focused Ambulatory Surgery Centers. Leverage your clinical expertise to build relationships, enhance product adoption, and ensure...
2 weeks ago
Clinical Solutions Specialist, Ambulatory Surgery Centers (ASC)- South Central
$76K - $114K *
Elevate the clinical sales landscape by driving growth in Electrophysiology-focused Ambulatory Surgery Centers. Leverage your clinical expertise to build relationships, enhance product adoption, and e...
2 weeks ago
Clinical Solutions Specialist, Ambulatory Surgery Centers (ASC)- West
$76K - $114K *
Grow your career with a dynamic role focused on driving sales and clinical engagement in Electrophysiology Ambulatory Surgery Centers. Leverage your clinical expertise to build relationships, enhance...
2 weeks ago
Clinical Solutions Specialist, Ambulatory Surgery Centers (ASC)- Southeast
$76K - $114K *
Unlock potential by driving growth in Electrophysiology-focused Ambulatory Surgery Centers. Leverage clinical expertise to build relationships, enhance product adoption, and ensure customer satisfacti...
2 weeks ago
Senior Regulatory Affairs Manager, Chemistry Manufacturing and Controls
$106K - $159K *
Transform regulatory strategies by providing CMC expertise to support product development and compliance in a dynamic pharmaceutical environment, ensuring quality and adherence to global standards thr...
2 weeks ago
Clinical Applications Specialist, Invasive Cardiology
$92K - $138K *
Help us enhance clinical education by delivering expert training and support to healthcare professionals. Drive product adoption and optimize user competencies while fostering strong relationships wit...
2 weeks ago
Clinical Application Specialist - General Imaging (NYC)
$110K - $165K *
Elevate your career by driving clinical education and training for GI Ultrasound. Collaborate with sales and customers to enhance technical competencies, optimize workflows, and improve patient care t...
2 weeks ago
$65K - $98K *
Champion growth in Alzheimer’s imaging sales by identifying leads, enhancing team efficiency, and collaborating with outside sales to drive referrals and expand market access for innovative healthcare...
2 weeks ago
Contrast Media Clinical Sales Specialist
$97K - $146K *
Partner with us to provide clinical support for contrast media, delivering education and product expertise to healthcare professionals while collaborating with internal teams to enhance patient care a...
2 weeks ago
Senior Director, Nonprofit and Arts & Cultural Customer Success
$150K - $204K *
Unlock potential by leading transformative customer success strategies for nonprofit and arts organizations. Drive retention, growth, and innovation through AI-enabled solutions while collaborating ac...
2 weeks ago
$101K - $132K *
Elevate your career by driving strategic partnerships with leading cloud providers. Collaborate across teams to enhance revenue growth and client satisfaction while managing key partner relationships...
2 weeks ago
IT Business Analyst – Apptio TBM
$73K - $110K *
Lead impactful projects to enhance Apptio TBM solutions, driving cost transparency, benchmarking, and strategic planning through collaboration with IT and business partners in a fully remote environme...
Reposted 2 weeks ago
$95K - $115K *
Drive client success as a key Account Manager, managing relationships across diverse industries. Oversee project lifecycles, enhance client experiences, and help shape the client services function fro...
2 weeks ago
$200K - $230K *
Strategize and lead comprehensive marketing initiatives to drive customer acquisition, enhance brand presence, and support revenue growth across diverse business segments. Oversee a high-performing te...
2 weeks ago
Specialty Development Executive - Southeast Territory
$130K - $140K *
Empower healthcare providers by promoting innovative colorectal cancer screening solutions, delivering exceptional support and education while strategically expanding product adoption across a designa...
Reposted 2 weeks ago
$80K - $100K *
Accelerate business growth by owning the full sales cycle and expanding strategic partnerships with enterprise retailers. Leverage insights to consistently exceed revenue targets and drive impactful s...
Reposted 2 weeks ago
$150K - $200K *
Advance partner success by optimizing enablement strategies and driving revenue growth through data-driven insights and strategic program management in a collaborative environment...
2 weeks ago
$130K - $160K *
Lead the end-to-end customer onboarding process, managing cross-functional teams to ensure timely delivery and value realization. Collaborate with customers to provide expert guidance and drive succes...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.