Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$110K - $130K *

Join a team that's dedicated to transforming patient care by executing strategic business plans and driving sales initiatives across a broad geographical region. Develop relationships with healthcare...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$104K - $145K *

Join us to lead a dynamic team managing consumer complaints in lending operations. You'll enhance complaint resolution processes, ensure regulatory compliance, and drive continuous improvement, all wh...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Engage with top-tier partners to define and execute innovative co-marketing strategies that amplify AI-driven growth. Oversee the entire partner marketing roadmap, ensuring measurable impact on pipeli...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$190K - $215K *

Champion the future of energy development by leading regional strategies, managing utility relationships, and driving contract negotiations. This role balances strategic oversight with tactical execut...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$225K - $250K *

Join us to lead the strategic growth of our data feeds portfolio, driving performance and innovation. Collaborate across teams to shape market strategies, enhance client value, and establish a scalabl...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$230K - $240K *

Inspire excellence by leading provider support initiatives, enhancing satisfaction, accountability, and clinical quality. Drive process innovation and mentorship in a dynamic environment, ensuring com...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$140K *

Join a team that's redefining data strategy and engineering. In this hands-on role, you'll build and optimize data infrastructure, develop predictive models, and collaborate with cross-functional team...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Shape the future of quality assurance by leading automated testing initiatives for cloud-based ERP systems, ensuring seamless integration and performance across various business processes and upgrades...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$132K - $170K *

Unlock client growth opportunities through strategic relationships, driving value in a fast-paced B2B sales environment. Collaborate with C-Level Executives across diverse sectors to ensure client sat...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$140K - $175K *

Join a team that's redefining partner management by owning high-value relationships, driving growth through strategic planning, and collaborating across departments to enhance customer outcomes and re...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$200K - $270K *

Accelerate progress at multi-state market development by building key relationships, navigating complex contracting processes, and driving approvals in Medicaid and managed care environments. Own the...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$100K - $120K *

Shape the future of clinical trials by driving business development initiatives, identifying opportunities with sponsors and CROs, and promoting CTSdatabase's services to enhance growth and profitabil...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$240K - $330K *

Transform the GTM Systems landscape by leading strategy, architecture, and operations. Drive efficiency across Sales, Marketing, and Customer Success through innovative solutions and data governance...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$106K - $150K *

Unlock potential by providing expert operational support for Windows environments. Manage complex incidents, ensure service availability, and collaborate across teams to enhance customer experiences i...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$210K - $250K *

Join a dynamic mental health team as a Collaborating Psychiatrist, providing clinical oversight and direct patient care. Engage in meaningful collaboration with PMHNPs while ensuring compliance and de...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Analyze and lead evaluations for human-services and public programs, creating frameworks and performance measures. Collaborate with stakeholders to translate findings into actionable insights, ensurin...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Lead the charge in tax management by preparing and reviewing complex returns, guiding a skilled team, and delivering exceptional client service while assuming responsibility for a diverse range of tax...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$95K - $130K *

Lead the charge in optimizing paid search strategies, managing a $700K-$1M monthly budget, and driving growth across multiple platforms. Own end-to-end account management, from keyword strategy to off...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$61K - $122K *

Join a team that's driving impactful sales strategies for leading nutrition brands. You will engage with healthcare professionals and expand market share through clinical insights and strong relations...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$117K - $161K *

Drive impactful clinical intelligence initiatives by analyzing AI opportunities, conducting feasibility studies, and collaborating with cross-functional teams to enhance patient care and operational e...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$335K - $387K *

Shape the future of virtual care by leading a dynamic clinical team, enhancing patient access, and driving innovative health solutions. This role combines clinical leadership with operational excellen...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Transform pharmacy outcomes by leading managed care initiatives that optimize clinical programs, enhance stakeholder collaboration, and drive cost efficiencies in pharmacy benefit management...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$96K - $207K *

Lead the charge in managing complex credit liquidations and rehabilitations. Collaborate with Portfolio Managers to optimize returns while ensuring compliance and risk management, fostering a positive...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$97K - $151K *

Unlock potential by managing agency relationships and driving sales growth in assigned territories. Utilize training, data analysis, and strategic initiatives to enhance performance and engagement, en...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$286K - $326K *

Champion engineering excellence by leading high-performing teams to innovate scalable, customer-centric solutions. Drive technical strategy and architecture while fostering a culture of continuous lea...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.