Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Senior Account Executive, Partnerships
$125K - $150K *
Engage in full-cycle sales by identifying and closing new client opportunities, focusing on experiential marketing solutions for youth and Gen Z. Build relationships, manage pipelines, and achieve sal...
2 weeks ago
Lead, Digital Product Management
$125K - $165K *
Optimize the digital journey by enhancing product evaluation experiences. Drive consumer confidence and collaboration across teams to accelerate purchase progression through seamless, data-driven web...
Reposted 2 weeks ago
Director, US Oncology Marketing Portfolio Strategy (Customer Engagement)
$190K - $300K *
Manage and optimize the digital marketing strategy for oncology products, enhancing customer engagement through innovative digital assets. Lead cross-functional teams to execute comprehensive marketin...
2 weeks ago
Specialty Development Executive - Atlantic Territory
$130K - $140K *
Elevate your career by joining a dynamic sales team driving colorectal cancer screening solutions. Engage healthcare professionals, provide education, and strategize business growth across a vibrant t...
Reposted 2 weeks ago
$229K - $330K *
Transform financial strategy for GTM operations, driving growth through data-driven insights and modernized processes. Collaborate with cross-functional teams to enhance performance, optimize investme...
2 weeks ago
$125K - $150K *
Accelerate growth by leveraging your extensive network to drive new business opportunities. Own the sales cycle from prospecting to closing, while shaping strategies that influence company success and...
2 weeks ago
Senior Manager, Global Benefits & Well-Being
$96K - $283K *
Lead the charge in global benefits and well-being program implementation, ensuring alignment with company values. Collaborate with HR teams and vendors to enhance employee experience and maintain comp...
2 weeks ago
$110K - $130K *
Drive efficient order management and logistics operations, ensuring compliance with pharmaceutical regulations while collaborating with internal teams and 3PL partners to optimize product flow and per...
2 weeks ago
Senior Technical Program Manager
$130K - $150K *
Lead the charge in driving program delivery and portfolio management for a dynamic Security team, ensuring effective execution of enterprise initiatives while fostering cross-functional collaboration...
2 weeks ago
Program Manager, Defense Manufacturing - GM Defense
$134K - $207K *
Drive cross-functional program management initiatives, ensuring successful execution from capture to delivery. Collaborate with stakeholders to align objectives, manage risks, and leverage GM's capabi...
2 weeks ago
$90K - $110K *
Transform telecom project delivery by managing design tasks, mentoring consultants, and ensuring budget adherence. Collaborate with stakeholders to mitigate risks and enhance project outcomes through...
2 weeks ago
Senior Information Security Specialist
$120K - $160K *
Join a team that's committed to enhancing our cybersecurity and GRC programs. You'll drive initiatives across risk management, compliance, and operational security, playing a vital role in strengtheni...
Reposted 2 weeks ago
$65K - $100K *
Transform construction projects by managing all phases from planning to completion. Collaborate with diverse teams to ensure quality, safety, and client satisfaction while preparing accurate estimates...
2 weeks ago
Specialty Sales Representative - Tampa / St. Petersburg / Sarasota
$120K - $150K *
Shape the future of healthcare by driving product adoption and brand awareness. Engage with healthcare professionals, build relationships, and execute territory strategies to influence market behavior...
2 weeks ago
Account Executive, Partnerships
$80K - $110K *
Join a team that's driving growth by identifying and closing new client opportunities in experiential marketing. Leverage your network and expertise to engage youth and Gen Z through innovative campai...
2 weeks ago
Director, Field Sales Engineering
$191K - $239K *
Lead the development and growth of a Sales Engineering team focused on new product incubation, driving adoption and revenue through strategic customer engagements and cross-functional collaboration to...
Reposted 2 weeks ago
$180K - $216K *
Empower small businesses by leading our omni-channel marketing strategy. Drive customer acquisition and retention through innovative campaigns, optimizing performance across digital and traditional ch...
2 weeks ago
$100K - $120K *
Innovate your career by driving go-to-market strategies and customer marketing for CPQ solutions. Collaborate across teams to launch initiatives, craft compelling narratives, and leverage AI tools to...
2 weeks ago
$88K - $121K *
Join a team that's redefining financial analytics by developing cutting-edge predictive models. Collaborate globally, analyze large datasets, and drive impactful solutions in the financial services in...
2 weeks ago
Enterprise Account Executive, New England
$144K - $170K *
Champion innovative AI security solutions by driving enterprise sales in New England. Leverage your expertise to build relationships, uncover customer needs, and exceed revenue targets in a fast-paced...
2 weeks ago
Senior Life Sciences Analyst, AI Model Training
$110K - $130K *
Empower life sciences innovation by evaluating AI model outputs, ensuring quality and accuracy. Collaborate with cross-functional teams to enhance predictive analytics and insights, bridging clinical...
2 weeks ago
$120K - $145K *
Innovate enterprise architecture solutions that enhance business operations. Collaborate with IT and business teams to tackle complex challenges, ensuring scalable, secure, and efficient systems acros...
2 weeks ago
Program Manager, HUB Operations
$88K - $105K *
Lead the management of pharmaceutical programs, ensuring client satisfaction and operational excellence. Oversee daily activities, supervise staff, and drive strategic planning while maintaining stron...
2 weeks ago
Principal Consultant - Senior SAP Sales Executive - New Business (US Market)
$150K - $180K *
Unlock new business opportunities by leveraging your SAP expertise and extensive network. Drive sales cycles from prospecting to closing, focusing on manufacturing and enterprise clients. Collaborate...
2 weeks ago
Associate Staff Engineer - INFOR M3 Technical Consultant
$100K - $120K *
Optimize your career as an Infor M3 Technical Consultant, leveraging 3-5 years of expertise in integrations and development. Collaborate with teams to design and support seamless enterprise solutions...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.