Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$65K - $98K *
Champion growth in Alzheimer’s imaging sales by identifying leads, enhancing team efficiency, and collaborating with outside sales to drive referrals and expand market access for innovative healthcare...
2 weeks ago
Contrast Media Clinical Sales Specialist
$97K - $146K *
Partner with us to provide clinical support for contrast media, delivering education and product expertise to healthcare professionals while collaborating with internal teams to enhance patient care a...
2 weeks ago
Senior Director, Nonprofit and Arts & Cultural Customer Success
$150K - $204K *
Unlock potential by leading transformative customer success strategies for nonprofit and arts organizations. Drive retention, growth, and innovation through AI-enabled solutions while collaborating ac...
2 weeks ago
$101K - $132K *
Elevate your career by driving strategic partnerships with leading cloud providers. Collaborate across teams to enhance revenue growth and client satisfaction while managing key partner relationships...
2 weeks ago
IT Business Analyst – Apptio TBM
$73K - $110K *
Lead impactful projects to enhance Apptio TBM solutions, driving cost transparency, benchmarking, and strategic planning through collaboration with IT and business partners in a fully remote environme...
Reposted 2 weeks ago
$95K - $115K *
Drive client success as a key Account Manager, managing relationships across diverse industries. Oversee project lifecycles, enhance client experiences, and help shape the client services function fro...
2 weeks ago
$200K - $230K *
Strategize and lead comprehensive marketing initiatives to drive customer acquisition, enhance brand presence, and support revenue growth across diverse business segments. Oversee a high-performing te...
2 weeks ago
Specialty Development Executive - Southeast Territory
$130K - $140K *
Empower healthcare providers by promoting innovative colorectal cancer screening solutions, delivering exceptional support and education while strategically expanding product adoption across a designa...
Reposted 2 weeks ago
$80K - $100K *
Accelerate business growth by owning the full sales cycle and expanding strategic partnerships with enterprise retailers. Leverage insights to consistently exceed revenue targets and drive impactful s...
Reposted 2 weeks ago
$150K - $200K *
Advance partner success by optimizing enablement strategies and driving revenue growth through data-driven insights and strategic program management in a collaborative environment...
2 weeks ago
$130K - $160K *
Lead the end-to-end customer onboarding process, managing cross-functional teams to ensure timely delivery and value realization. Collaborate with customers to provide expert guidance and drive succes...
2 weeks ago
Director, Nursing Inpatient Trauma
$100K - $120K *
Unlock potential by providing clinical and administrative leadership to enhance patient care standards. Collaborate with medical staff and departments to ensure compliance and drive strategic initiati...
2 weeks ago
Registered Nurse (RN) | Endoscopy
$67K - $100K *
Join a team that's dedicated to delivering exceptional nursing care by developing personalized care plans, providing emotional support, and collaborating with healthcare professionals to enhance patie...
2 weeks ago
$67K - $100K *
Reimagine patient care by operating MRI equipment to produce diagnostic images. Collaborate with healthcare professionals to ensure efficient procedures and maintain high standards in a dynamic enviro...
2 weeks ago
$67K - $100K *
Lead the charge in delivering exceptional nursing care, developing tailored care plans, and providing holistic support to patients and families. Collaborate with healthcare teams to ensure optimal pat...
2 weeks ago
Senior Director, Clinical Operations
$270K - $280K *
Join a team that's driving clinical excellence by overseeing trial execution, managing timelines, budgets, and CROs. Collaborate with stakeholders to ensure compliance and quality while mentoring team...
2 weeks ago
$110K - $130K *
Lead the accounting function, ensuring compliance and accuracy in financial reporting. Partner with the CFO to build scalable processes and controls, supporting growth in a multinational industrial en...
2 weeks ago
Director, Strategic Sales - South Central
$150K - $180K *
Join us to drive strategic sales growth across key verticals in the South Central U.S. Lead complex enterprise sales cycles, engage with C-suite stakeholders, and develop a robust pipeline to achieve...
2 weeks ago
$170K - $210K *
Engage in client development and system architecture while leading a team to enhance client satisfaction. Collaborate on solutions, mentor staff, and drive growth through effective communication and s...
2 weeks ago
Transportation Adjuster (Michigan)
$75K - $95K *
Unlock potential by navigating complex transportation claims with expertise, ensuring resolution while collaborating with clients, attorneys, and medical providers to uphold regulatory standards in a...
Reposted 2 weeks ago
Sr Field Application Engineer (TOLA)
$160K - $250K *
Transform customer experiences by leading technical sales solutions for wireless routers and managed services. Collaborate with partners and clients across diverse industries, ensuring optimal connect...
2 weeks ago
$240K - $330K *
Unlock potential by leading a global enablement team to develop and implement a comprehensive strategy that enhances sales effectiveness and drives revenue growth across all customer-facing roles...
2 weeks ago
Technical Solutions Consultant
$110K - $130K *
Drive your career forward by partnering with clients to transform complex challenges into actionable technical solutions, managing the design process from discovery to implementation while collaborati...
2 weeks ago
$170K - $250K *
Transform complex financial workflows into intuitive designs, leading end-to-end product design efforts. Collaborate with teams to create user-centric experiences, leveraging data insights and innovat...
2 weeks ago
Document Control Specialist - Remote, US
$88K - $154K *
Transform document management processes by overseeing workflows, tracking, and compliance for critical projects. Leverage your expertise to enhance efficiency and ensure accurate record retention whil...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.