Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$65K - $98K *

Champion growth in Alzheimer’s imaging sales by identifying leads, enhancing team efficiency, and collaborating with outside sales to drive referrals and expand market access for innovative healthcare...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$97K - $146K *

Partner with us to provide clinical support for contrast media, delivering education and product expertise to healthcare professionals while collaborating with internal teams to enhance patient care a...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$150K - $204K *

Unlock potential by leading transformative customer success strategies for nonprofit and arts organizations. Drive retention, growth, and innovation through AI-enabled solutions while collaborating ac...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$101K - $132K *

Elevate your career by driving strategic partnerships with leading cloud providers. Collaborate across teams to enhance revenue growth and client satisfaction while managing key partner relationships...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$73K - $110K *

Lead impactful projects to enhance Apptio TBM solutions, driving cost transparency, benchmarking, and strategic planning through collaboration with IT and business partners in a fully remote environme...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Drive client success as a key Account Manager, managing relationships across diverse industries. Oversee project lifecycles, enhance client experiences, and help shape the client services function fro...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$200K - $230K *

Strategize and lead comprehensive marketing initiatives to drive customer acquisition, enhance brand presence, and support revenue growth across diverse business segments. Oversee a high-performing te...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$130K - $140K *

Empower healthcare providers by promoting innovative colorectal cancer screening solutions, delivering exceptional support and education while strategically expanding product adoption across a designa...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $100K *

Accelerate business growth by owning the full sales cycle and expanding strategic partnerships with enterprise retailers. Leverage insights to consistently exceed revenue targets and drive impactful s...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Media

$150K - $200K *

Advance partner success by optimizing enablement strategies and driving revenue growth through data-driven insights and strategic program management in a collaborative environment...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$130K - $160K *

Lead the end-to-end customer onboarding process, managing cross-functional teams to ensure timely delivery and value realization. Collaborate with customers to provide expert guidance and drive succes...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Unlock potential by providing clinical and administrative leadership to enhance patient care standards. Collaborate with medical staff and departments to ensure compliance and drive strategic initiati...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$67K - $100K *

Join a team that's dedicated to delivering exceptional nursing care by developing personalized care plans, providing emotional support, and collaborating with healthcare professionals to enhance patie...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$67K - $100K *

Reimagine patient care by operating MRI equipment to produce diagnostic images. Collaborate with healthcare professionals to ensure efficient procedures and maintain high standards in a dynamic enviro...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$67K - $100K *

Lead the charge in delivering exceptional nursing care, developing tailored care plans, and providing holistic support to patients and families. Collaborate with healthcare teams to ensure optimal pat...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$270K - $280K *

Join a team that's driving clinical excellence by overseeing trial execution, managing timelines, budgets, and CROs. Collaborate with stakeholders to ensure compliance and quality while mentoring team...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead the accounting function, ensuring compliance and accuracy in financial reporting. Partner with the CFO to build scalable processes and controls, supporting growth in a multinational industrial en...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$150K - $180K *

Join us to drive strategic sales growth across key verticals in the South Central U.S. Lead complex enterprise sales cycles, engage with C-suite stakeholders, and develop a robust pipeline to achieve...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$170K - $210K *

Engage in client development and system architecture while leading a team to enhance client satisfaction. Collaborate on solutions, mentor staff, and drive growth through effective communication and s...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$75K - $95K *

Unlock potential by navigating complex transportation claims with expertise, ensuring resolution while collaborating with clients, attorneys, and medical providers to uphold regulatory standards in a...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$160K - $250K *

Transform customer experiences by leading technical sales solutions for wireless routers and managed services. Collaborate with partners and clients across diverse industries, ensuring optimal connect...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$240K - $330K *

Unlock potential by leading a global enablement team to develop and implement a comprehensive strategy that enhances sales effectiveness and drives revenue growth across all customer-facing roles...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Drive your career forward by partnering with clients to transform complex challenges into actionable technical solutions, managing the design process from discovery to implementation while collaborati...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Media

$170K - $250K *

Transform complex financial workflows into intuitive designs, leading end-to-end product design efforts. Collaborate with teams to create user-centric experiences, leveraging data insights and innovat...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Staffing

$88K - $154K *

Transform document management processes by overseeing workflows, tracking, and compliance for critical projects. Leverage your expertise to enhance efficiency and ensure accurate record retention whil...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.