Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$85K - $100K *

Unlock your potential by providing comprehensive medical care and education to obstetrical and gynecological patients. Collaborate with healthcare teams to ensure quality treatment and promote patient...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$220K - $240K *

Shape the future of loyalty by leading the technical execution and innovation of AI-powered features in a rapidly evolving product landscape, driving cross-functional initiatives with a focus on archi...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Media

$104K - $141K *

Elevate your career by designing high voltage transmission lines using PLS-CADD. Collaborate with multi-discipline teams, manage project scopes, and deliver expert consultation to ensure successful pr...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$155K - $210K *

Advance your career by leading high voltage transmission line projects, utilizing PLS-CADD software. Collaborate with multidisciplinary teams, mentor junior engineers, and serve as a client-facing exp...

United StatesRemote

2 weeks ago

  •   15+ years exp.  •   Manufacturing & Automotive

$135K - $149K *

Create impactful eLearning experiences to enhance revenue team performance. Collaborate with stakeholders to design, implement, and analyze training programs that drive sales effectiveness and continu...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$111K - $163K *

Join a team dedicated to driving successful IT project outcomes through effective management methodologies, ensuring on-time and on-budget completion while aligning with business goals and fostering c...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $150K *

Lead the strategy and execution of marketing programs to enhance member experience throughout their journey, ensuring clear communication and engagement across all touchpoints while collaborating with...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$88K - $140K *

Shape the future of public service by leading technology consulting projects that enhance operational efficiency and strategic goals for state and local agencies, ensuring compliance and delivering im...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$160K - $259K *

Champion regulatory excellence by leading European strategies for innovative therapies. Drive successful submissions and interactions with health authorities, ensuring compliance and alignment across...

RemoteRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$232K - $325K *

Empower innovation by serving as a leading expert in relevance evaluation. Collaborate to enhance ranking and recommendation systems, driving product strategy through rigorous analysis and shaping the...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Media

$90K - $115K *

Unlock potential by leading integrations that enhance customer workflows and streamline operations. Collaborate with partners and engineering to create reliable, scalable solutions that simplify data...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $140K *

Join our team to shape innovative industrial solutions, driving product strategy and execution. You'll lead cross-functional efforts, ensuring compliance and safety while delivering impactful products...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

$130K - $160K *

Join a team that's shaping the future of identity security by developing impactful enablement programs for pre-sales teams. Collaborate with cross-functional leaders to enhance skills and drive busine...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Drive innovation in AI by building and evaluating machine learning models. Collaborate with experts to design experiments, analyze data, and communicate findings effectively to enhance model performan...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Elevate your career by driving the design and deployment of AVEVA MES projects. Collaborate with cross-functional teams to ensure quality solutions, mentor junior engineers, and enhance user adoption...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$62K - $139K *

Champion data integrity by designing and executing comprehensive test plans for ETL processes and large-scale data platforms, ensuring quality and accuracy across systems while collaborating in an Agi...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$112K - $141K *

Innovate customer success in quantum computing by driving adoption and technical enablement. Collaborate with cross-functional teams to optimize performance, design workflows, and create educational c...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$67K - $199K *

Unlock your potential as you design and develop impactful Power BI solutions, enhancing analytics capabilities and driving strategic decision-making in a dynamic sales environment. Collaborate with cr...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Engineer cutting-edge blockchain infrastructure for financial markets. Drive architecture, design proofs of concept, and ensure interoperability while collaborating with teams to meet institutional re...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$90K - $120K *

Lead the charge in enhancing safety standards across multiple construction projects. Collaborate with field teams to ensure compliance and improve practices, making safety a priority and fostering a c...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$82K - $108K *

Grow your career with a dynamic role focused on building relationships and driving sales growth in the wholesale sector. Collaborate with internal teams to deliver exceptional customer service and ach...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$125K - $150K *

Champion the development of scalable, cloud-native applications, enhancing data pipelines and integrations. Collaborate with teams to transform raw data into actionable insights, driving improvements...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $120K *

Advance patient care at our Virtual Cancer Clinic by providing essential support, education, and coordination for cancer screening and prevention, ensuring timely follow-up and compassionate care for...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Join a team that's driving strategic growth through partnerships with GSIs, MSPs, and VARs. This role combines relationship building, market strategy, and sales leadership to generate revenue and opti...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$83K - $152K *

Shape the future of Category Partnerships by crafting compelling narratives and sales materials that drive engagement and revenue. Collaborate with teams to translate insights into strategic stories t...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Media

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.