Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Insurance Litigation Attorney (CA License Required) – Remote
$150K - $200K *
Champion the management of insurance litigation files, providing mentorship and expertise while navigating complex legal matters and advocating for clients in a dynamic remote work environment...
Reposted 2 days ago
Principal Software Engineer - Emerging Technology & AI - Remote
$177K - $236K *
Transform the future of technology as a Principal Software Engineer, leading AI experimentation and prototyping. Collaborate across teams to design scalable solutions, mentor engineers, and drive inno...
2 days ago
$92K - $135K *
Join our Finance, Risk & Compliance team as a Senior Financial Analyst, driving financial planning, budgeting, and reporting processes. Collaborate with departments to enhance insights and efficiency...
2 days ago
Senior Application Sales Engineer - Power Transformers
$110K - $130K *
Drive innovative solutions in technical sales for power transformers, collaborating with key stakeholders to secure new business and enhance customer relationships while leveraging engineering experti...
2 days ago
$110K - $130K *
Lead the charge in transforming client challenges into innovative Salesforce solutions. Collaborate with stakeholders to design, demo, and scope projects, ensuring seamless transitions to delivery whi...
2 days ago
Senior Director, Web Strategy and Operations
$160K - $200K *
Shape the future of our web strategy by leading a cross-functional team to optimize user experience, drive demand generation, and enhance web performance. Your expertise will transform our website int...
2 days ago
Global Medical Affairs, Medical Director- Chronic Weight Management
$220K - $298K *
Transform chronic weight management strategies on a global scale, driving evidence generation and medical communication while leading cross-functional collaboration to deliver impactful healthcare sol...
Reposted 2 days ago
Account Manager - Encaps and Inclusions
$80K - $95K *
Grow your career by driving sales and expanding market presence in the Encaps & Inclusions sector. Collaborate with cross-functional teams to deliver innovative solutions while managing key accounts a...
2 days ago
Strategic Account Manager-QSR & Casual Dining
$80K - $95K *
Shape the future of customer engagement by managing key accounts, driving revenue growth, and enhancing client satisfaction in the QSR and Casual Dining sectors. Collaborate across departments to impl...
2 days ago
$85K *
Champion quality assurance by developing and executing test strategies to ensure technology solutions meet business and user requirements. Collaborate with cross-functional teams to enhance applicatio...
2 days ago
$120K - $140K *
Empower organizational success by leading total rewards programs, ensuring competitive compensation and benefits. Collaborate with HR and finance to drive compliance and continuous improvement, while...
2 days ago
Director, Engineering, Data, and AI
$150K - $180K *
Drive operational excellence by leading engineering, data, and AI teams. Collaborate with stakeholders to translate strategic goals into actionable plans, ensuring high-quality project delivery and te...
2 days ago
CV Ultrasound Clinical Solution Consultant Manager - Midwest Zone
$207K - $225K *
Drive business growth and customer satisfaction by leading a high-performing Cardiovascular Clinical Solutions Consultant team, collaborating across sales and clinical operations to enhance customer e...
2 days ago
$135K - $160K *
Engage in designing and optimizing AI solutions to enhance automation and analytics, collaborating across teams to integrate advanced AI capabilities into core products, while ensuring ethical standar...
2 days ago
Associate Director, Quality and Standards Pharmacist
$132K - $213K *
Join a team that's dedicated to maintaining high standards in pharmacy operations. Collaborate with cross-functional teams to ensure quality and compliance in prescription verification, enhancing pati...
Reposted 2 days ago
Regulatory RIM Business Analyst & Managed Services Consultant
$100K - $120K *
Transform regulatory environments by configuring and supporting Veeva Vault RIM systems. Collaborate with clients to ensure compliance and reliability while implementing ongoing managed services and a...
2 days ago
Lead Product Manager- Quote Management (CPQ)
$129K - $186K *
Join a team that's redefining enterprise solutions by leading product strategy and execution for Quote Management. Collaborate across teams to deliver AI-powered tools that enhance sales processes and...
Reposted 2 days ago
Senior Technology & Systems Consultant
$130K *
Join a dynamic team to manage client technologies, mentor peers, and deliver IT assessments. This hands-on role emphasizes client service and consultant development, ensuring optimal performance acros...
2 days ago
$76K - $96K *
Elevate client success by leading national media investments across diverse channels. Drive performance through strategic planning, negotiation, and data analysis while collaborating with cross-functi...
2 days ago
$94K - $131K *
Join a team that's transforming manufacturing solutions through SAP expertise. Collaborate with clients to implement and optimize SAP ME and S/4 HANA systems, enhancing production efficiency and drivi...
2 days ago
$130K - $150K *
Take ownership of transformative AI solutions by embedding within business units, identifying key operational challenges, and rapidly delivering demonstrable results that drive adoption and innovation...
2 days ago
$84K - $106K *
Drive impactful digital video strategies and optimize campaigns across programmatic and direct publisher environments, focusing on CTV and streaming. Collaborate with cross-functional teams to enhance...
2 days ago
Director of Customer Service Operations
$150K - $175K *
Unlock your potential as a hands-on leader in customer service operations, driving performance and quality across teams. Collaborate with cross-functional partners to enhance processes and empower you...
2 days ago
$120K - $160K *
Contribute to malaria programming by providing technical leadership and support to country teams, ensuring quality interventions, compliance, and strategic resource investments across health facilitie...
2 days ago
Mainframe System / Network Architect (z/OS) | Remote | 6+ Months
$125K - $150K *
Join a dynamic team to manage and optimize enterprise mainframe environments, ensuring high availability and performance. Collaborate with cross-functional teams on strategic initiatives, system upgra...
2 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.