Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$120K - $150K *

Join a team that's shaping the future of AI engineering by leading a dynamic group of engineers and Technical Leads. Drive workforce strategy, enhance team capabilities, and ensure sustainable deliver...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$75K - $90K *

Drive exceptional client outcomes by managing complex, cross-functional projects. Collaborate with diverse teams to ensure clarity, timely execution, and risk management, transforming strategy into ac...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$184K - $342K *

Lead the charge in driving account growth through strategic sales planning and relationship management while delivering exceptional customer service to enhance client satisfaction in the retail sector...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $190K *

Lead the charge in shaping data platform strategies and governance, driving innovative solutions and team development. Collaborate with partners to enhance AI readiness and ensure successful technical...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$66K - $99K *

Elevate patient care by providing compassionate, individualized nursing in a collaborative hospice environment. Utilize your skills to manage symptoms and support families during critical times, ensur...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$188K - $282K *

Drive design excellence in fintech by leading a team to enhance payment, billing, and timekeeping solutions. Collaborate with cross-functional partners to shape user experiences that empower legal pro...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Legal & Accounting

$75K - $90K *

Transform fundraising success by leading streamer recruitment and engagement for a dynamic program. Drive revenue growth through strategic partnerships, community management, and innovative campaigns...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$177K - $290K *

Transform UX operations by unifying decision-making and enhancing workflows across disciplines. Drive continuous improvement through automation and strategic partnerships, ensuring a cohesive UX organ...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$88K - $105K *

Transform client marketing strategies by leading integrated campaigns, translating data into actionable insights, and driving measurable results. Collaborate cross-functionally while mentoring junior...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Unlock potential by leading tailored service solutions that drive client success. Collaborate with stakeholders to strategize and execute sales plans, ensuring exceptional engagement and delivering va...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$151K - $189K *

Engineer innovative virtualization solutions that enhance customer strategy and value. Collaborate in a dynamic environment, leading customer workshops as a subject-matter expert across VMware and Nut...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $117K *

Elevate proposal development by collaborating with global teams to create high-quality, tailored proposals for Biologics and Drug Product offerings, ensuring alignment with customer needs and driving...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$175K - $210K *

Innovate and lead the technical vision for large-scale product systems, driving cross-functional initiatives and engineering excellence while mentoring teams to enhance growth and impact across multip...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$125K - $150K *

Champion a robust security program, leading a team to achieve SOC 2 Type 2 attestation while ensuring secure engineering practices across diverse products and cloud environments. Drive compliance, ris...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Drive new dealer acquisition by managing the full sales cycle, building strong relationships, and executing strategic territory plans to achieve sustainable revenue growth in a competitive automotive...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$110K - $125K *

Shape the future of integration projects by owning technical direction, ensuring seamless execution, and fostering client trust. Collaborate with sales and development teams to deliver clear documenta...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $115K *

Lead the charge in optimizing paid social strategies for eCommerce clients while managing multiple platforms. Drive performance growth with actionable insights, testing strategies, and ensure strong a...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Unlock your potential as a strategic advisor, driving enterprise success on Amazon. Manage complex initiatives, build executive partnerships, and deliver transformative results through innovative adve...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Optimize coding education and compliance for healthcare providers. Lead a team to enhance clinical documentation, develop training plans, and ensure adherence to regulations, driving improvements in b...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Elevate your career by managing coding operations, ensuring accuracy and compliance across healthcare settings. Lead educational initiatives for staff, optimize workflows, and drive improvements in co...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$108K - $130K *

Lead the charge in driving sales and operational excellence across multiple stores. Empower teams to deliver exceptional customer experiences while analyzing market trends and implementing strategic b...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Grow your career by managing a dynamic sales territory, driving revenue, and building relationships within the medical community. Leverage your expertise to educate clients and expand business opportu...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $181K *

Accelerate progress at driving SaaS revenue by developing new markets and relationships. Own the sales cycle from prospecting to proposal management, collaborating cross-functionally to deliver value...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$90K - $105K *

Lead the charge in expanding OEM business by identifying opportunities, nurturing client relationships, and delivering tailored HVACR solutions that drive customer satisfaction and business growth acr...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$134K - $219K *

Unlock potential by leading global site start-up strategies for complex clinical trials. Drive operational excellence, ensure compliance, and collaborate with cross-functional teams to accelerate stud...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.