Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$90K - $100K *
Champion transformative solutions as an IT Business Analyst, driving strategic vision across departments. Collaborate closely with stakeholders to enhance business information systems and optimize pro...
Reposted 2 weeks ago
Field Reimbursement Specialist
$94K - $148K *
Lead the charge in enhancing patient access to specialty medications by educating healthcare providers on reimbursement processes and resolving access barriers. Your expertise will bridge the gap betw...
2 weeks ago
Regional Director (K-12 Enterprise Sales)
$100K - $125K *
Lead the charge in developing strategic partnerships and driving revenue growth through consultative sales. This role requires a proven track record in exceeding quotas, fostering relationships, and d...
2 weeks ago
$125K - $150K *
Unlock potential by driving new enterprise sales in cybersecurity. Own the full sales cycle, from prospecting to closing, while expanding existing accounts. Collaborate with teams to deliver tailored...
2 weeks ago
$105K - $120K *
Explore customer success by managing relationships, driving product adoption, and ensuring satisfaction for enterprise clients. Collaborate cross-functionally to enhance the customer experience and ac...
2 weeks ago
Senior Manager, Regulatory Affairs
$120K - $145K *
Transform regulatory strategies for rare disease and cardio-pulmonary drug-device programs. Collaborate with cross-functional teams to ensure compliance and drive successful submissions globally, supp...
2 weeks ago
Southeastern Territory Representative
$80K - $108K *
Unlock sales potential by driving strategies in the Florida, Alabama, and Georgia territories. Engage with pest management professionals and distributors to expand market share while managing customer...
Reposted 2 weeks ago
$148K - $256K *
Shape the future of data engineering by architecting scalable, cloud-native data platforms on Azure and Databricks. Influence the organization’s data practices to leverage AI-driven insights, driving...
Reposted 2 weeks ago
$198K - $297K *
Engage in a dynamic role that empowers team collaboration and drives results in a leading organization recognized for innovation and excellence in performance, fostering an environment of growth and p...
Reposted 2 weeks ago
Field Clinical Applications Specialist
$90K - $110K *
Elevate your career by providing expert support in molecular diagnostics, driving product implementation, and fostering strong relationships with clinical laboratories to ensure successful adoption an...
2 weeks ago
$126K - $162K *
Drive project success by leading design and construction phases, managing teams, and ensuring client satisfaction in commercial and mission-critical environments. Collaborate with stakeholders to deli...
2 weeks ago
St. Louis, MO based Clinical Specialist - Remote, USA
$100K - $140K *
Transform your career by providing clinical support and training in surgical procedures. Collaborate with surgical teams to ensure optimal patient outcomes while managing inventory and compliance in a...
2 weeks ago
$110K - $130K *
Shape multi-year commodity strategies for electrical equipment, ensuring robust supplier negotiations and capacity management. Collaborate with engineering to optimize designs and mitigate risks throu...
2 weeks ago
Associate Director, Biostatistics
$174K - $203K *
Empower clinical innovations by leading statistical strategies in oncology trials. Collaborate with cross-functional teams to design studies, analyze data, and support regulatory submissions, ensuring...
Reposted 2 weeks ago
VP - Insurance Services Agency Manager
$145K - $175K *
Shape the future of insurance services by leading strategic growth, empowering teams, and enhancing client outcomes across North America. Drive performance and compliance while fostering strong partne...
2 weeks ago
$160K - $170K *
Join a team that's redefining production excellence by leading end-to-end photo and video shoots. You'll manage budgets, build partnerships, and create efficient workflows while ensuring brand integri...
2 weeks ago
Director, Endowments & Foundations
$150K - $175K *
Transform the future of nonprofit investment strategies by leading client engagement, business development, and team coordination. Drive growth and enhance service delivery for a diverse portfolio of...
2 weeks ago
$170K - $231K *
Join a team that's passionate about transforming defense tech through innovative product management. Drive impactful software solutions, collaborate with diverse teams, and shape the future of nationa...
2 weeks ago
Director, Technology Communications, Hims & Hers
$150K - $180K *
Lead strategic communications for technology and AI, translating complex narratives into compelling stories that build trust and credibility. Collaborate with cross-functional teams to enhance brand r...
2 weeks ago
Senior Account Manager, Programmatic
$85K - $100K *
Lead the execution and optimization of programmatic campaigns, fostering client relationships and mentoring team members to achieve strategic goals and enhance performance in a collaborative environme...
2 weeks ago
$100K - $120K *
Unlock potential by leading advanced training initiatives for Army National Guard units. Collaborate with commanders to enhance operational readiness through expert guidance in intelligence processes...
2 weeks ago
Security Operations Analyst - West Coast Shift
$100K - $125K *
Optimize security operations by triaging and investigating alerts, mitigating cyber threats effectively. Join a dedicated team to enhance your analyst skills while actively protecting organizations fr...
Reposted 2 weeks ago
Head of National Strategic Accounts
$250K - $300K *
Champion strategic growth by leading the charge to secure complex health system accounts. Drive transformative deals with hands-on coaching, leveraging deep relationships and expertise to elevate team...
Reposted 2 weeks ago
Manager, Market Intelligence & Commercial Analytics
$110K - $130K *
Lead the charge in market intelligence and sales support, bridging teams to drive insights and strategies in U.S. power markets. Collaborate cross-functionally to identify opportunities and enhance cu...
2 weeks ago
Senior Software Engineer, Core Pricing
$166K - $230K *
Champion seamless loan management and customer relations as you lead initiatives that optimize collections and enhance user experience. Contribute to automation and process improvements to empower our...
Reposted 2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.