Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$147K - $184K *
Shape the future of sales operations by analyzing performance metrics, driving strategic initiatives, and leading cross-functional projects to enhance efficiency and productivity in the SMB sector. Jo...
Reposted 1 week ago
Data Solutions Architect - Remote
$160K - $213K *
Innovate data architecture strategies and AI solutions, establishing scalable standards across platforms. Collaborate with leaders to define architecture roadmaps that ensure secure, governed, and eff...
1 week ago
Senior Manager, MSP Demand Generation
$160K - $180K *
Shape the demand generation strategy for the MSP segment, leading a high-impact team to optimize funnel performance and drive revenue growth through innovative marketing approaches and AI tools...
1 week ago
Manager, Software Engineering - Engineering Tools
$120K - $148K *
Join a team that's shaping the future of AEC software by leading engineering talent and enhancing workflows. Drive innovation in Autodesk Revit add-ins and tools while fostering a collaborative enviro...
1 week ago
Account Executive, Government & Public Sector
$105K - $140K *
Transform your career by leading government sales efforts in a high-growth environment. Leverage your expertise to build relationships, create pipelines, and drive revenue for a cutting-edge product i...
1 week ago
Minnesota West (Minneapolis, MN or St. Cloud, MN) based Territory Sales Manager - Remote, USA
$120K - $260K *
Drive high CVAC adoption among physicians in Minnesota East, exceeding sales quotas while effectively communicating product value. Build relationships, train accounts, and ensure compliance, all while...
1 week ago
$90K - $110K *
Champion client success by managing enterprise accounts, driving growth, and enhancing internal processes. Collaborate with cross-functional teams to deliver exceptional service and support, ensuring...
1 week ago
$120K - $145K *
Unlock AI-driven engineering transformation by collaborating with clients to enhance SDLC processes. Drive measurable improvements in delivery speed and quality through innovative solutions and hands...
1 week ago
Core Enterprise Account Executive EST/CST - Remote
$222K - $278K *
Take ownership of enterprise-level sales, driving strategic relationships and complex negotiations to deliver impactful solutions for key customers. Engage with C-Level executives to transform operati...
1 week ago
$120K - $145K *
Shape the future of security engineering by embedding robust practices into development. Collaborate with engineers to enhance platform security, automate compliance, and build scalable tools that emp...
1 week ago
Product Manager (Single Cell Sequencing Tech)
$135K - $195K *
Unlock your potential as you drive product success in the genomics field. Collaborate across teams to advocate for customers, define market needs, and launch innovative products that shape the future...
1 week ago
Domain Architect (Technology Integration Management Office)
$114K - $190K *
Lead the charge in crafting target-state architecture that integrates business processes, applications, and data. Your role will shape enterprise transformation while ensuring alignment with strategic...
Reposted 1 week ago
$135K - $160K *
Lead the charge in shaping the technical landscape of digital accessibility. Drive innovation by designing scalable systems that enhance user experience while mentoring engineers and collaborating acr...
1 week ago
Sr. Manager, Commercial Systems - Salesforce (REMOTE)
$110K - $130K *
Innovate commercial systems to enhance revenue operations, integrating tools like Salesforce and AI for streamlined workflows. Collaborate across teams to ensure data integrity and optimize processes...
1 week ago
Lead QA Engineer, Enterprise Platform
$120K - $145K *
Pioneer the development of secure platform capabilities for enterprise clients, collaborating across teams to define product scope, manage complex requirements, and ensure successful delivery in highl...
1 week ago
$125K - $150K *
Join a team that's shaping the future of cloud infrastructure by managing a vast AWS estate. Drive automation, maintain platform health, and deliver new features while ensuring compliance in a regulat...
1 week ago
Sr. Manager, Regional Accounts
$110K - $140K *
Transform regional accounts by developing strategic programs and building strong relationships with local decision-makers. Drive growth through effective budgeting, insights, and innovative solutions...
1 week ago
Director, Media Strategy & Client Partnerships
$139K - $157K *
Elevate your career by leading transformative digital marketing strategies for high-profile clients. Drive measurable growth through innovative media plans and creative ideation while fostering truste...
1 week ago
Change Management Lead - R&D Advisory
$100K - $120K *
Help us drive change management initiatives in life sciences R&D, enhancing efficiency and effectiveness across research, clinical, and regulatory operations while leading stakeholder engagement and a...
1 week ago
Director, Corporate Sales - Consulting
$170K - $230K *
Accelerate growth by leading a high-performing sales team in the Professional Services & Consulting sector. Drive strategy, performance, and revenue while fostering a culture of collaboration and exce...
1 week ago
Territory Sales Manager, Solar and Storage, Midwest (Remote)
$90K - $110K *
Champion market growth by building partnerships with distributors and installers in the Midwest. Drive sales strategies for residential and commercial solar and storage products, ensuring SMA's leader...
1 week ago
Senior Outbound Product Manager
$149K - $240K *
Unlock potential by driving go-to-market strategies for innovative AI products. Collaborate across teams to translate technical capabilities into compelling narratives, ensuring customer success and m...
1 week ago
Senior Statistical Programmer Analyst - T
$136K - $239K *
Unlock your potential by leading statistical programming efforts in clinical trials. Collaborate with cross-functional teams to analyze and report clinical data, ensuring compliance with industry stan...
1 week ago
$125K - $225K *
Elevate project success by leading multidisciplinary teams in nuclear design and program management, ensuring safety, quality, and compliance across all phases of construction and operations for compl...
1 week ago
Senior Product Manager - Inventory
$159K - $273K *
Shape the future of home listings by driving supply growth and enhancing buyer experiences. Lead AI-driven initiatives to optimize inventory presentation and engagement, ensuring Redfin remains the go...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.