Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$90K - $100K *

Join a team that's passionate about transforming complex scientific data into engaging communications. Collaborate with cross-functional experts to deliver high-quality medical content and strategies...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$163K - $224K *

Transform your career by automating and improving infrastructure systems, collaborating with engineering teams, and enhancing operational efficiency as part of a dynamic team focused on self-service s...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$112K - $140K *

Drive regional agronomy leadership, ensuring effective execution and support for grower adoption. Connect agronomic insights with commercial strategies to enhance impact and foster customer confidence...

Sioux Falls, SDRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $140K *

Reimagine client success by managing relationships and ensuring seamless communication across teams. Drive operational excellence and enhance client satisfaction through proactive updates, coordinatio...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$148K - $254K *

Transform connected systems by designing and deploying advanced anomaly detection models. Lead a team to build robust pipelines, ensuring real-time analysis and integration across AI and engineering t...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$175K - $241K *

Empower a high-performing sales team in the Financial Services sector, driving new business growth and fostering long-term client relationships. Lead with a consultative approach to exceed revenue tar...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$175K - $190K *

Shape the future of search by designing intuitive, engaging experiences that enhance user interactions and drive revenue. Collaborate with cross-functional teams to create a seamless journey for neigh...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$124K - $138K *

Shape the future of vendor relations by managing the RTV process, negotiating effectively, and collaborating cross-functionally to maximize recovery value and streamline operations within the supply c...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$135K - $160K *

Lead the charge in designing cutting-edge infrastructure for large-scale AI deployments. Collaborate with multidisciplinary teams to ensure seamless execution from concept to construction, maintaining...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$146K - $206K *

Join a team that's driving innovation in card acquisition by leveraging technology and data insights to create seamless user experiences and foster customer loyalty. Collaborate with cross-functional...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $145K *

Grow your career with a dynamic role leading AI Native pods, managing cross-functional teams through education and client engagements, while championing AI SDLC practices and ensuring delivery excelle...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$108K - $135K *

Unlock your potential by driving sales success in specialty biopharmaceuticals. Collaborate with healthcare professionals to enhance patient outcomes and execute strategic business plans within primar...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$111K - $150K *

Drive innovative civil engineering solutions for utility-scale solar projects. Lead design teams, mentor engineers, and ensure high-quality project execution while collaborating with clients and stake...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Innovate with us as a Senior Software Engineer, driving core feature development and automation across the stack. Collaborate with diverse teams to enhance scalability and performance in a dynamic, mi...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$300K - $325K *

Drive your career with a strategic leadership role focused on enhancing marketing initiatives, optimizing client engagement, and achieving commercial growth across diverse financial services sectors...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Finance & Insurance

$125K - $150K *

Unlock potential by joining a high-impact team focused on managing global financial crime risks. Collaborate across functions to develop risk-based policies and controls that ensure compliance and sup...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $115K *

Optimize customer success by driving engagement and retention, ensuring clients maximize value from services. Collaborate with teams to enhance the customer experience and advocate for their needs, co...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$125K - $150K *

Join our dynamic team as you lead Methods and Insights, driving engineering excellence through effective people management, operational delivery, and innovative system building. Empower engineers to t...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$115K *

Transform your career by driving net-new logo sales in the mid-market space. Leverage your HRMS/Payroll expertise to exceed quotas and build lasting client relationships while benefiting from exceptio...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$200K - $225K *

Accelerate growth by leading a global Mid-Market sales organization, driving strategy and execution across regions. Build a high-performing team, optimize sales processes, and foster partnerships to a...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Transform clinical operations by leading a dynamic team, ensuring high-quality trial management, and driving innovation through technology and AI solutions. Your strategic oversight will enhance perfo...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Drive network expansion by engaging providers and negotiating contracts to enhance Medicare services. Collaborate with a remote team to ensure network adequacy and build strong relationships with heal...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $216K *

Transform program administration for a large federal services initiative, overseeing workforce planning, financial operations, and compliance. Collaborate with diverse teams to enhance operational eff...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$190K - $225K *

Drive scientific engagement as a Senior Medical Science Liaison, fostering relationships with Key Opinion Leaders and healthcare professionals. Leverage your expertise in cardiovascular disease to sup...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Join us to lead groundbreaking research in quantum technologies, shaping innovative measurement approaches and collaborating with cross-functional teams to drive product development and experimental v...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.