Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$100K - $140K *
Champion the early stages of the sales journey by qualifying leads, conducting discovery calls, and collaborating cross-functionally to enhance customer engagement and drive automation solutions in ma...
1 week ago
Director, Sales Engineering (Presales) - Retirement & Pension
$165K - $195K *
Transform enterprise sales and modernization for retirement technology. Lead a team of Sales Engineers, engaging with diverse stakeholders to deliver tailored solutions and drive impactful customer ex...
1 week ago
Manager, Network Connectivity & Carrier Strategy
$150K - $200K *
Drive the future of network connectivity by managing site selection, carrier negotiations, and team leadership to ensure robust, efficient data center connections globally. Collaborate with engineerin...
1 week ago
Principal Specialist Sales Engineer, Zero Trust Branch - Healthcare/SLED
$175K - $251K *
Lead the charge in transforming customer experiences through innovative cloud security solutions, leveraging your expertise to craft tailored technical presentations and solutions that drive strategic...
Reposted 1 week ago
Associate Medical Director (Promotional Medical Education)
$100K - $125K *
Manage a team of medical writers to develop impactful scientific content, ensuring accuracy and compliance. Collaborate with clients and cross-functional teams to drive medical strategies and delivera...
Reposted 1 week ago
Operational Technology (OT) Engineer
$76K - $118K *
Explore a pivotal role in enhancing operational technology solutions for Army facilities. Collaborate with diverse teams to ensure system security, reliability, and compliance while supporting moderni...
1 week ago
$125K - $150K *
Elevate your career as a Senior Data Engineer, driving innovation in cloud-native data pipelines and architectures. Leverage your expertise in structured credit and financial analytics to modernize da...
1 week ago
$182K - $243K *
Lead a dynamic communications team to shape brand narrative and media presence, driving public safety technology's impact through proactive strategy and crisis management across various platforms and...
Reposted 1 week ago
$210K - $250K *
Lead global revenue growth by driving B2B sales strategies, managing high-performing teams, and expanding market presence across key sectors. Collaborate cross-functionally to achieve ambitious revenu...
1 week ago
$110K - $130K *
Empower clients by optimizing estate, gift, and income taxes through strategic planning. Collaborate with internal leaders to enhance client relationships and deliver measurable results in a dynamic...
1 week ago
Virtual Telehealth Nurse Practitioner
$100K - $120K *
Elevate patient care by delivering virtual health services, ensuring compliance with regulations, and fostering teamwork in a dynamic environment. Utilize your expertise to provide accurate diagnoses...
1 week ago
Sr Software Engineer (Backend)
$140K - $165K *
Join a dynamic team as you lead the design and development of complex software systems. Drive technical direction, mentor peers, and ensure high-quality, scalable solutions that align with business go...
1 week ago
Senior Director, Software Engineering
$145K - $190K *
Lead the charge in designing and optimizing scalable data pipelines using Azure, PySpark, and Airflow. Collaborate with teams to ensure data quality and performance while mentoring engineers and drivi...
1 week ago
Patient Programming / Ambassador Manager
$205K - $228K *
Champion patient-focused initiatives by leading strategy and execution of ambassador programs. Build relationships with patients and advocacy groups to enhance engagement and ensure their voices shape...
1 week ago
Senior Product Marketing Manager
$100K - $130K *
Drive product marketing for innovative defense tech solutions. Collaborate with cross-functional teams to shape strategies, develop compelling narratives, and execute impactful campaigns that enhance...
1 week ago
21GRAMS- VP, Medical Strategy Director
$180K - $195K *
Elevate healthcare marketing by transforming complex science into impactful strategies. Lead multidisciplinary teams to inspire creativity, drive behavior change, and build trusted client relationship...
Reposted 1 week ago
Senior Digital Customer Success Campaign Manager
$121K - $146K *
Drive digital customer success initiatives by designing and optimizing targeted journeys throughout the customer lifecycle, enhancing engagement and adoption while collaborating cross-functionally to...
1 week ago
$120K - $150K *
Innovate as you guide Fortune 500 clients in leveraging AI solutions. Collaborate with sales teams, deliver dynamic presentations, and serve as trusted technical advisor to modernize legacy systems an...
Reposted 1 week ago
Sr. Lead OBT Implementation Manager
$185K - $210K *
Lead the charge in transforming TMC implementations by defining processes, configuring platforms, and training teams to ensure seamless transitions and rapid go-lives across multiple projects simultan...
1 week ago
$87K - $139K *
Join a dynamic team as a senior technical lead in enterprise data engineering, responsible for architecting and optimizing scalable data platforms. Drive data quality and observability while collabora...
Reposted 1 week ago
Federal Senior Product Analytics Engineer
$142K - $186K *
Deliver trusted, governed product data by designing scalable ELT pipelines and analytics models. Collaborate across teams to ensure data quality and compliance, empowering stakeholders with self-servi...
1 week ago
Regulatory and Compliance Permitting Specialist - Remote, US
$88K - $154K *
Elevate project success by managing permit tracking and regulatory compliance, ensuring adherence to local, state, and federal requirements while supporting incentive-related activities for optimal be...
1 week ago
Frontend Developer- Senior- REMOTE
$150K - $165K *
Innovate user experiences by transforming legacy workflows into modern web applications. Lead the development of data-driven analytics tools using cutting-edge technologies, collaborating with cross-f...
1 week ago
Supervisory Facility Operations Specialist
$89K - $116K *
Contribute to the efficient operation of park facilities by managing maintenance programs, supervising staff, and ensuring compliance with safety regulations. Collaborate with a diverse team to enhanc...
1 week ago
Field Reimbursement Manager-Atlantic
$185K - $230K *
Shape the future of patient access by leading reimbursement strategies and support for rare disease therapies. Collaborate cross-functionally to enhance provider education and patient understanding, e...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.