Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$90K *
Transform strategic partnerships and drive revenue growth by managing national accounts, developing key relationships, and leveraging insights to achieve measurable business results in a dynamic envir...
1 week ago
Director of Conservation Partnerships
$85K - $100K *
Partner with us to cultivate impactful conservation partnerships, enhancing collaboration across affiliates and national teams. This strategic role drives communication, alignment, and capacity for ac...
1 week ago
Principal Analytics Consultant (Sigma)
$125K - $150K *
Engineer transformative Sigma analytics solutions, leading complex projects that unlock business insights for clients. Collaborate closely with stakeholders to build actionable data-driven products, e...
Reposted 1 week ago
$75K - $100K *
Join a dynamic preconstruction team to evaluate blueprints and forecast costs for fiber deployments. Utilize your expertise in estimating to ensure competitive bids and profitable projects in a fast-p...
Reposted 1 week ago
Manager, Corporate Development
$115K - $150K *
Champion strategic growth by leading M&A initiatives, conducting financial analysis, and collaborating with cross-functional teams to drive successful transactions and enhance corporate capabilities...
1 week ago
$87K - $108K *
Empower customer success by providing expert technical support for bioprocessing products. Collaborate with teams to troubleshoot issues, enhance product knowledge, and ensure a positive experience fo...
1 week ago
$122K - $184K *
Drive operational excellence by leading physician practices in Ohio. Collaborate with clinical and regional teams to enhance performance, accountability, and patient experience while translating data...
1 week ago
$140K - $228K *
Lead the charge in enhancing cybersecurity by driving detection engineering, incident response, and automation. Collaborate cross-functionally to secure cloud architectures and improve operational eff...
1 week ago
Staff Engineer, Detection and Response
$225K - $281K *
Lead the charge in shaping detection and response strategies, driving hands-on initiatives to enhance security architecture and incident management. Collaborate across teams to ensure robust threat de...
1 week ago
$88K - $100K *
Transform enterprise sales by driving full-cycle processes, building multi-stakeholder relationships, and leveraging AI tools to achieve quota and deliver impactful solutions to large organizations...
1 week ago
Account Specialists (Covington, LA)
$160K - $192K *
Engage healthcare providers and drive commercial performance in a defined territory. Collaborate with cross-functional teams to support product launches and ensure patient access to innovative therapi...
1 week ago
$80K - $95K *
Transform brand vision into cohesive creative suites across digital and print. Collaborate with cross-functional teams to deliver engaging designs that enhance customer experience and uphold brand sta...
1 week ago
$110K - $130K *
Join a team that's transforming software sales by driving technical solutions and creative outreach. Lead the full sales cycle and collaborate cross-functionally to deliver unique insights and busines...
Reposted 1 week ago
Lead Software Platform Engineer, MLOps
$200K - $270K *
Join a team pioneering AI/ML platform engineering, enhancing scalable infrastructure to empower scientific innovation. Shape the future of distributed systems and MLOps, collaborating across teams to...
Reposted 1 week ago
Field Clinical Specialist (Remote)
$115K - $180K *
Champion the use of innovative medical technology by training and supporting clinical staff in the effective application of the Globe PF System, ensuring successful clinical trials and enhancing patie...
1 week ago
$150K - $180K *
Innovate your career by forming executive relationships and leading complex sales cycles. Drive value through consultative engagements, leveraging insights to elevate conversations with senior leaders...
1 week ago
Telehealth Clinical Supervisor
$80K - $95K *
Advance your career as a Telehealth Clinical Supervisor, providing leadership and clinical oversight to therapists delivering IOP-level care. Collaborate with a dedicated team to enhance patient outco...
1 week ago
$90K - $110K *
Unlock potential by driving business development initiatives in renewable energy. Collaborate with teams to identify opportunities, build customer relationships, and support proposal development for b...
1 week ago
Director - PMO - Aviation Construction
$135K - $160K *
Lead and optimize PMO strategies for major aviation and infrastructure programs. Drive governance, risk management, and stakeholder engagement while mentoring a high-performing team to ensure project...
1 week ago
Staff Software Engineer - Data
$198K - $297K *
Join us to lead the design and evolution of a cutting-edge Real-Time Analytics Platform, driving high-throughput, low-latency data solutions. Collaborate with cross-functional teams to enhance scalabi...
1 week ago
Litigation Fellowship, Separation of Powers (Fall 2027)
$100K *
Partner with us to defend individual liberties and combat government overreach. Engage in impactful public-interest law through a year-long fellowship, honing your legal skills alongside seasoned prof...
Reposted 1 week ago
Federal Health (VA, DHA, HHS) Account Executive (Remote: DC/MD/VA)
$288K - $500K+*
Drive new business growth and foster strategic partnerships within Federal Healthcare Agencies, leveraging expertise in Veeam solutions and deep understanding of market dynamics to enhance client rela...
Reposted 1 week ago
$125K - $150K *
Engineer scalable Azure data solutions, leading architecture and modernization initiatives. Collaborate with teams to define standards and ensure high-performance data integration, governance, and sec...
1 week ago
Director, Engineering, Platform/Services
$216K - $318K *
Drive innovation as you lead engineering teams to build and scale Life360's critical platforms. Ensure reliability and security while fostering a culture of accountability and technical excellence for...
1 week ago
Enterprise Solutions Architect
$170K - $187K *
Join a team that's shaping the future of Enterprise Architecture by driving innovative solutions and strategic design for hybrid banking systems. Collaborate across diverse teams to create scalable, f...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.