Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$108K - $135K *

Drive client success by managing a diverse portfolio, enhancing relationships, and implementing strategies for retention and growth. Utilize analytical insights to navigate complex client needs and fo...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$92K - $155K *

Unlock potential by partnering with leaders to drive talent strategies that align with business goals, enhance team performance, and foster a culture of growth and inclusivity in a fast-paced, innovat...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Unlock potential by designing and managing Azure infrastructure, ensuring seamless hybrid connectivity and robust disaster recovery. Collaborate across teams to enhance operations, automate processes...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$80K - $95K *

Drive client success by managing relationships, optimizing collections, and resolving issues. Collaborate with diverse stakeholders to ensure satisfaction and compliance while leading a team to enhanc...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Lead market expansion and provider relationships through consultative sales strategies, driving revenue growth and pipeline management within a dynamic healthcare environment while leveraging AI tools...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Transform customer success by leading a technical account management team, driving subscription growth, and enhancing service delivery through innovative AI solutions and strategic partnerships...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $200K *

Shape strategic client partnerships and drive account growth while leading financial oversight and team development, ensuring exemplary service delivery aligned with commercial goals across global ope...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Business Services

$100K - $120K *

Join our team to lead and supervise electrical construction projects, ensuring safety, efficiency, and quality. Drive growth in systems integration services while managing resources and fostering clie...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$172K - $203K *

Elevate women's health outcomes by developing advanced machine learning models. Lead projects, mentor junior team members, and collaborate with cross-functional teams to drive innovation and commercia...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$130K - $145K *

Drive growth by building strong partnerships with travel agencies, enhancing market share and brand awareness. Collaborate across teams to identify opportunities and execute strategies, making a signi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$275K - $325K *

Drive the venture and private equity business by owning strategy, partnerships, and P&L. Collaborate with teams to establish Flex as the primary financial institution in the sector, leveraging your ex...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$81K - $122K *

Champion a positive employee relations environment by guiding, supporting, and resolving employee concerns. Collaborate with management and HR to ensure consistent and equitable practices that align w...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Transportation

$110K - $130K *

Empower credit unions by driving new sales of digital banking solutions. Leverage your network to identify and close business opportunities, manage the full sales cycle, and exceed ambitious revenue t...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$84K - $127K *

Manage and enhance database operations, ensuring security and performance. Collaborate with teams to develop innovative solutions and maintain integrity controls while contributing to policy formulati...

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$175K - $210K *

Drive the go-to-market strategy for an AI-powered enterprise search platform, leading a high-performing sales team to achieve revenue goals while fostering strategic partnerships and aligning with pro...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$110K - $130K *

Empower your career by joining a dynamic Deal Desk team to support global sales. Drive deal execution and manage the end-to-end deal lifecycle, enhancing operational efficiency and collaborating acros...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$159K - $215K *

Take ownership of Windows endpoint reliability and lifecycle management. Enhance provisioning, patching, and automation while collaborating with cross-functional teams to drive improvements and mentor...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$130K - $140K *

Transform enterprise partnerships by leading complex sales cycles, aligning stakeholders, and driving impactful solutions for large educational organizations. Collaborate with executives to enhance op...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Lead the charge in optimizing pricing processes, ensuring alignment across teams to drive strategic growth and enhance profitability while maintaining compliance and governance in pricing operations...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Grow your career with a dynamic team dedicated to providing advanced water treatment solutions. Leverage your technical sales expertise and relationship-building skills to drive revenue and foster str...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Innovate secure network solutions by engineering and supporting robust infrastructure. Collaborate with cross-functional teams to enhance security technologies, ensuring reliable connectivity and comp...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$108K - $135K *

Engage in driving sales success within primary care and specialty biopharmaceuticals. Collaborate effectively to execute strategic business plans, achieve sales goals, and launch new products in a dyn...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$180K - $220K *

Join a dynamic team to lead a growing golf company, driving strategy, product expansion, and financial performance. Own the P&L and collaborate with experts to innovate and scale, transforming the gol...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $145K *

Shape government funding strategies by partnering with sector leaders to identify and secure opportunities that align with research priorities, enhancing organizational impact through effective captur...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$140K *

Pioneer a transformative creative vision by integrating brand storytelling with cutting-edge AI technology. Collaborate across teams to elevate marketing assets, ensuring every piece reflects our uniq...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.