Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Registered Nurse Care Manger - Juneau Cty
$71K - $97K *
Join a dedicated team as you support members in care coordination, focusing on health needs, education, and lifestyle modifications while managing records and completing assessments remotely. Enjoy a...
Reposted 1 week ago
Lead Applied Scientist, Document Understanding
$147K - $274K *
Develop advanced document understanding systems to enhance legal content processing. Collaborate across teams to design, deploy, and evaluate models that drive measurable impact in legal, tax, and acc...
1 week ago
Senior Software Engineer- Rust / C++
$94K - $176K *
Drive innovation in document processing by leading high-impact projects, shaping architecture, and optimizing performance in a queue-driven pipeline. Collaborate across teams to enhance AI products an...
1 week ago
$100K - $185K *
Elevate the legal landscape by leveraging AI to transform workflows. Collaborate with law firms to design and implement innovative solutions, ensuring successful adoption of advanced legal technologie...
1 week ago
Senior Principal Implementation Consultant
$100K - $185K *
Empower clients by leveraging deep ONESOURCE Direct Tax expertise to design innovative solutions using AI and automation tools. Engage directly with customers, manage projects, and drive efficiency wh...
1 week ago
Director, AI Specialty Sales - Small Law
$255K - $474K *
Lead AI revenue growth by driving strategy and execution across sales, partnerships, and customer success. Build and manage a high-performing team to enhance AI adoption and market share in the legal...
1 week ago
$100K - $185K *
Reimagine legal workflows as an AI Solutions Architect, driving AI adoption in law firms. Collaborate with teams to design and implement innovative solutions, enhancing efficiency and client advocacy...
1 week ago
Customer Success Manager - Global Trade
$106K - $197K *
Join a team that's dedicated to empowering customers in global trade. As a Customer Success Manager, you'll leverage your expertise to drive client success, foster relationships, and ensure optimal va...
1 week ago
Senior Medical Economics Analyst
$89K - $107K *
Join a team that's transforming healthcare through data-driven insights. As a Senior Medical Economics Analyst, you'll lead analytics initiatives, mentor a team, and collaborate with leaders to enhanc...
1 week ago
$230K - $345K *
Join a dynamic team as a Senior Manager, leading Account Executives to drive new business growth, enhance market presence, and foster a high-performance sales culture focused on accountability and cus...
1 week ago
Specification Consultant - Minnesota, North Dakota or South Dakota
$75K - $115K *
Design and deliver expert door hardware specifications for architectural projects, ensuring compliance and effective communication with stakeholders. Play a key role in enhancing market penetration th...
1 week ago
$110K - $135K *
Unlock excellence in PCB design and manufacturing by leading DFM initiatives, developing complex multilayer layouts, and shaping best practices across engineering teams to enhance product performance...
1 week ago
$100K - $122K *
Take ownership of financial planning and analysis for G&A expenses, driving insights and reporting for senior leadership. Collaborate with teams to enhance budgeting, forecasting, and variance analysi...
1 week ago
$76K - $96K *
Join a team that's dedicated to transforming healthcare through compassionate nursing. As a vital member, you'll provide high-quality patient care, collaborate with interdisciplinary teams, and thrive...
1 week ago
Hospital Inpatient Coding Manager
$77K - $121K *
Join a team that's redefining coding excellence by leading operational strategies, managing staff performance, and ensuring compliance in inpatient coding processes to enhance efficiency and quality a...
1 week ago
Senior Corporate Development and Planning Analyst
$95K - $115K *
Take ownership of financial and operational analysis for strategic initiatives, delivering critical insights and reporting to support executive decision-making while driving accuracy and efficiency in...
Reposted 1 week ago
Research Computing Services Manager
$110K - $130K *
Unlock potential by managing research computing infrastructure, guiding teams, and ensuring efficient operations. Collaborate with a dedicated team to drive innovations in patient care while enjoying...
1 week ago
$120K - $145K *
Elevate healthcare through strategic AI product management, driving innovation and lifecycle management of AI solutions. Collaborate cross-functionally to align business objectives with customer needs...
1 week ago
$95K - $125K *
Optimize HR excellence in the Midwest by driving talent development, enhancing employee engagement, and supporting General Managers in fostering a high-performance culture. Act as a strategic partner...
Reposted 1 week ago
$53K - $110K *
Unlock potential by leveraging data analysis to support public health initiatives. Collaborate on quantitative and qualitative evaluations, ensuring data integrity and contributing to impactful progra...
1 week ago
$150K - $160K *
Lead the charge in managing complex programs within Navy Medicine, ensuring seamless integration of systems and exceptional client support while overseeing personnel and contract performance for optim...
1 week ago
$110K - $130K *
Empower enterprise growth by identifying and nurturing relationships with C-suite executives. Drive consultative sales, tailor solutions, and collaborate across teams to enhance client experiences and...
1 week ago
$87K - $135K *
Drive your career forward by leading systems engineering for a cloud-based enterprise system. Engage in architecture development, integration, and modernization efforts while ensuring security and ope...
1 week ago
$95K - $115K *
Champion customer acquisition and revenue growth by leading paid search strategies, optimizing campaigns, and mentoring a team. Drive performance through data analysis and cross-functional collaborati...
1 week ago
Senior Principal Software Engineer
$243K - $318K *
Elevate your career by providing technical leadership across Dev AI platforms. Shape architectural strategies, drive cross-organizational initiatives, and enhance engineering quality while collaborati...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.