Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$110K - $130K *

Join a dynamic team providing strategic legal counsel on employment law matters, including employee relations and litigation management. Collaborate with HR and business leaders to mitigate risks and...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $120K *

Shape the future of talent acquisition by driving full life cycle recruitment for financial advisors. Collaborate with leadership and engage candidates to build a diverse talent pipeline while trackin...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$108K - $184K *

Unlock potential by leveraging clinical expertise to enhance pharmacy benefit management, analyze drug trends, and build strong client relationships. Drive strategic recommendations and support client...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$220K - $250K *

Lead enterprise security operations and resilience, driving cyber risk strategy and innovation. Collaborate cross-functionally to embed security principles, modernize defenses, and build high-performi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$139K - $208K *

Join a team that's transforming Global Supply Chain and ERP processes. As a Staff Business Process Leader, you'll drive process standardization, support ERP transformations, and engage with stakeholde...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Aerospace & Defense

$110K - $130K *

Optimize and support database platforms, focusing on MySQL and SQL Server migrations to AWS. Lead performance tuning, replication, and maintenance while collaborating with developers to enhance databa...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K *

Take ownership of complex mortgage loan evaluations, ensuring compliance with guidelines while assessing borrower risk. Collaborate with internal teams and vendors to facilitate loan approvals and mai...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$83K - $140K *

Join a dynamic team to drive insurance product design and implementation. Collaborate cross-functionally to manage projects, ensuring alignment with strategic goals while facilitating effective busine...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $112K *

Lead the charge in clinical trial monitoring, ensuring compliance and data integrity while managing site operations and training staff. Collaborate with teams to deliver high-quality patient care and...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $112K *

Join a team that's dedicated to advancing clinical research by ensuring high standards of care and compliance in monitoring clinical trials. Leverage your expertise in oncology and clinical monitoring...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$175K - $210K *

Empower your marketing expertise to drive strategy, revenue, and brand positioning across multiple segments. Lead a dynamic team, collaborate with executives, and shape customer advocacy initiatives t...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$136K - $204K *

Transform enterprise marketing by owning ABM strategy, driving pipeline growth, and executing tailored campaigns. Collaborate cross-functionally to engage key accounts and achieve revenue targets thro...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$70K - $105K *

Collaborate with cross-functional teams to enhance EHR workflows, improve operations, and optimize patient care through effective configuration and analysis of Professional Billing Claims applications...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$163K - $306K *

Champion the future of laboratory innovation by leading global product strategy, connecting emerging technologies and customer insights to drive impactful business initiatives across diverse markets...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$143K - $196K *

Drive strategic financial leadership at a key manufacturing site, collaborating with diverse teams to enhance operational performance, support decision-making, and ensure compliance with global standa...

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$107K - $204K *

Pioneer innovative contracting solutions in a dynamic environment. Leverage your expertise in U.S. Government and commercial contracts to drive success within integrated project teams while ensuring c...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$82K - $131K *

Drive comprehensive audits and enhance internal controls across business units. Collaborate with stakeholders to assess risks, implement improvements, and ensure compliance while leading audit engagem...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$54K - $135K *

Design innovative fire sprinkler systems by analyzing building plans and specifications. Collaborate on equipment selection and optimize designs using cutting-edge software. Ensure compliance with saf...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$66K - $142K *

Join a team that's dedicated to optimizing healthcare services through effective utilization management. Leverage your clinical expertise to assess and coordinate care, ensuring members receive approp...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$174K - $374K *

Unlock potential by leading medical management initiatives remotely, supporting member needs and optimizing clinical services for optimal care. Leverage your expertise in Orthopedic Spine or Neurosurg...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$82K - $182K *

Develop and maintain QuickBase applications while leading complex analytics projects. Ensure data integrity and support clinical performance reporting. Collaborate with stakeholders to drive continuou...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$127K - $172K *

Elevate your career by shaping user experiences as a UI/UX Developer. Leverage 10+ years of expertise in React SPAs and responsive design to modernize financial applications. Collaborate across teams...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$131K - $178K *

Unlock your potential by leading a dynamic Agile team in developing enterprise applications. Leverage your AWS expertise and hands-on coding skills to drive innovation and mentor developers while ensu...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$83K - $112K *

Transform your career by leveraging your analytical skills to enhance application systems. Collaborate with teams to improve workflows, execute tests, and support mission-driven initiatives that stren...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$129K - $175K *

Champion the optimization of mission-critical Oracle EBS environments, ensuring seamless database administration and support for complex financial systems. Collaborate with cross-functional teams to e...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.