Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Director, Global Real-World Evidence & Health Outcomes Scientist, Oncology
$204K - $340K *
Lead the charge in generating impactful real-world evidence to support oncology products, ensuring alignment with market needs and regulatory requirements while collaborating across teams to drive evi...
1 week ago
Medicaid Certification Consultant
$70K - $120K *
Lead transformative Medicaid initiatives by guiding project oversight, ensuring timely execution, and enhancing stakeholder engagement. Collaborate with teams to streamline operations and achieve stra...
1 week ago
Manager, ERP Engineering (BTPAI)
$135K - $160K *
Join us to lead the deployment of AI-driven ERP solutions, enhancing SAP S/4HANA capabilities. Collaborate with cross-functional teams to ensure scalable, reliable, and secure automation across critic...
1 week ago
$450K - $480K *
Join a dynamic team as a leader in enterprise sales, driving growth in the BFSI sector. You'll develop strategies, mentor talent, and build relationships with key stakeholders to deliver transformativ...
1 week ago
Analytics Engineer 5 - Ads Identity & Signals
$330K - $500K+*
Optimize data models and pipelines for identity graph construction, ensuring accurate entity matching and resolution. Collaborate across teams to deliver actionable insights and maintain data quality...
1 week ago
Principal Architect - Data Governance
$174K - $224K *
Empower organizations by shaping data governance strategies that enhance security, compliance, and operational resilience. Collaborate with cross-functional teams to deliver impactful governance solut...
1 week ago
$95K - $115K *
Transform multi-channel campaign strategies to drive client success. Manage audience logic, funnel progression, and clear business objectives while balancing multiple strategies and ad-hoc requests ef...
Reposted 1 week ago
$90K - $110K *
Engage in impactful construction scheduling, collaborating with teams to analyze and optimize project timelines. Leverage your expertise to identify risks, enhance reporting, and drive project success...
1 week ago
$100K - $120K *
Elevate project success by developing precise cost estimates for complex construction initiatives. Collaborate with teams to analyze costs, prepare reports, and guide projects from concept to delivery...
1 week ago
Senior Structural Engineer 1 - Nuclear
$84K - $129K *
Empower your career by joining a dynamic team in structural engineering, tackling innovative projects in nuclear facilities. Collaborate, guide, and utilize advanced tools to design and analyze struct...
1 week ago
Traveling General Superintendent - Mission Critical
$175K - $320K *
Champion mission-critical project delivery by leading multidisciplinary teams, ensuring safety, quality, and efficiency. Drive financial performance and client satisfaction through strategic planning...
1 week ago
Traveling Project Executive - Mission Critical
$200K - $300K *
Lead the charge in managing large-scale mission-critical projects, ensuring strategic execution, financial performance, and team development. Drive client satisfaction and operational excellence in fa...
1 week ago
Quality of Care and Clinical Review Nurse
$69K - $125K *
Join a dynamic team to oversee quality of care investigations and improvement initiatives, ensuring compliance with regulatory standards while enhancing patient outcomes and organizational efficiency...
1 week ago
Director - Statistics - Lilly Regenerative Medicines
$193K - $308K *
Join a team that's redefining statistical leadership in clinical research. Drive innovative study designs, enhance drug development effectiveness, and influence critical decisions through data-driven...
1 week ago
Senior Oncology Account Manager, Washington
$150K - $230K *
Drive impactful oncology solutions by building relationships with key stakeholders, promoting innovative products, and exceeding performance goals in a dynamic biopharma environment. Collaborate effec...
1 week ago
Senior Oncology Account Manager, San Francisco
$150K - $230K *
Unlock potential by driving oncology product success through strategic relationships and innovative solutions. Lead market engagement, exceed performance goals, and ensure patient access while embodyi...
1 week ago
Senior Oncology Account Manager, Lansing
$150K - $230K *
Engage with key stakeholders to promote oncology products, build relationships, and drive brand value. Utilize market insights to develop effective strategies, ensuring patient access and compliance w...
1 week ago
Senior Oncology Account Manager, Rochester
$150K - $230K *
Elevate oncology product promotion by building strong relationships with key stakeholders. Drive performance goals through effective marketing strategies and innovative solutions, ensuring timely acce...
1 week ago
Senior Oncology Account Manager, New Orleans
$150K - $230K *
Champion the promotion of oncology products, building strong relationships with key stakeholders. Drive performance goals, manage territory effectively, and ensure patient access to treatments while e...
1 week ago
Senior Oncology Account Manager, Orlando
$150K - $230K *
Drive the promotion of oncology products by building relationships with key stakeholders, exceeding performance goals, and ensuring patient access to therapies while managing territory resources effec...
1 week ago
Senior Oncology Account Manager, Fort Myers
$150K - $230K *
Unlock potential by driving oncology product success through strategic relationships and innovative solutions. Lead efforts to enhance patient access and exceed performance goals while navigating a co...
1 week ago
Senior Oncology Account Manager, Seattle
$150K - $230K *
Accelerate progress at Revolution Medicines by driving oncology product sales, building strong relationships with healthcare professionals, and ensuring patient access to innovative therapies in a dyn...
1 week ago
$80K - $95K *
Transform automation systems by leading controls hardware projects, from design to implementation. Drive innovation in electrical design, mentor engineers, and ensure high-quality project delivery whi...
Reposted 1 week ago
$110K - $172K *
Optimize your career by managing the full contract lifecycle, ensuring compliance, and driving profitable execution of agreements. Collaborate with cross-functional teams to enhance customer relations...
1 week ago
Oracle Cloud Financials Delivery Architect
$135K - $160K *
Join a team that's shaping the future of Oracle Cloud solutions. As a Delivery Architect, you'll lead complex projects, guide clients through implementations, and drive innovative strategies to optimi...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.