Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$100K - $120K *

Transform utility project estimating through advanced analysis, mentoring, and collaborative support. Provide best-in-class service, ensuring accuracy and efficiency in project estimations while guidi...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$115K - $140K *

Unlock potential by leading product development for Salesforce Health Cloud solutions. Collaborate with cross-functional teams to prioritize and deliver impactful software that enhances patient servic...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$210K - $250K *

Champion transformative data strategies and lead technical pursuits in AI and data migration. Drive client success and practice growth while enhancing market presence through strategic partnerships an...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$130K - $150K *

Lead a dynamic team of Solutions Consultants, driving sales success through hands-on leadership, strategic deal support, and continuous improvement in a fast-paced environment focused on HR tech solut...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$135K - $155K *

Join a team that's dedicated to enhancing clinical workflows in Radiation Oncology. As a Clinical Success Manager, you'll train clinics, solve problems, and foster relationships to ensure customer sat...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$68K - $93K *

Join a team that's dedicated to driving sales and enhancing customer relationships in the animal health sector. Utilize innovative strategies and digital tools to maximize performance and deliver exce...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$180K - $210K *

Transform technology operations by leading strategic initiatives, enhancing cybersecurity, and fostering cross-functional collaboration to support mission-driven projects and a remote-first workforce...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$118K - $174K *

Champion innovative ERP solutions, translating complex business needs into effective technical strategies. Lead architecture, customization, and integration efforts while optimizing system performance...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$77K - $85K *

Join a dedicated team to enhance clients' independence and quality of life through tailored occupational therapy interventions. Collaborate in a supportive environment, focusing on daily living skills...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$82K - $115K *

Innovate faculty management and student engagement strategies while coaching and supporting educators. Drive academic excellence and uphold performance standards within a dynamic educational environme...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Join a dynamic team to provide expert pharmacy consulting, educate patients on medications, and deliver clinical healthcare services while ensuring safety and compliance. Mentor colleagues and enhance...

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$140K - $170K *

Advance project execution by managing vendor relationships and internal teams to deliver a new web-based application. Oversee timelines, risks, and stakeholder alignment to ensure successful project o...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Staffing

$98K - $157K *

Shape comprehensive sales support strategies by managing estimation, bidding, and proposal processes. Collaborate with sales teams to align offerings with customer requirements and ensure adherence to...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Join a team that's dedicated to ensuring the quality and safety of clinical trials. As a Senior Clinical Research Associate, you'll manage site relationships, oversee monitoring activities, and contri...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$85K - $100K *

Elevate customer engagement by providing expert technical training and consulting. Collaborate with sales teams to enhance product understanding and drive growth through tailored demonstrations and su...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$150K - $230K *

Drive impactful oncology solutions by building relationships with key stakeholders. Collaborate with internal teams to enhance patient access and exceed performance goals while managing territory reso...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Join a team that's transforming oncology care by promoting innovative treatments and building strong relationships with healthcare professionals. Drive brand value and ensure patient access while lead...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$101K - $132K *

Join a team that's at the forefront of client success by leading implementation efforts. Drive operational excellence while mentoring your team and collaborating cross-functionally to enhance customer...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $230K *

Drive impactful oncology solutions by building strong relationships with key stakeholders, promoting innovative products, and exceeding performance goals in a dynamic biopharma environment. Your exper...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Engage key stakeholders in oncology by promoting innovative products, building relationships, and driving access to care. Lead strategic initiatives to exceed performance goals while embodying corpora...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Lead the charge in promoting innovative oncology solutions while building strong relationships with key stakeholders. Drive performance goals and enhance patient access through strategic engagement an...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Transform healthcare by building strong relationships with key oncology stakeholders. Drive product promotion and exceed performance goals while ensuring patient access to innovative therapies in a dy...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$175K - $210K *

Transform the landscape of emerging therapies by leading strategic clinical innovation, guiding development, and ensuring regulatory readiness for novel therapeutic solutions across early- and mid-sta...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$114K - $167K *

Pioneer tailored ERP solutions, optimizing business processes and data integration. Collaborate with teams to enhance performance and compliance while leading transformation in services and resources...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $160K *

Unlock potential by serving as a strategic liaison between Finance, Facilities, and Supply Chain functions and IT, ensuring alignment of technology capabilities with business priorities and driving su...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Aerospace & Defense

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.