Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$120K - $140K *
Shape the future of federal financial operations by driving user adoption and change management for a new tool. Collaborate with stakeholders to enhance user experience, streamline processes, and ensu...
1 week ago
$80K - $95K *
Join a dynamic team to drive enterprise sales strategies, engaging key decision-makers and generating high-value opportunities in cybersecurity. Collaborate cross-functionally to build relationships a...
1 week ago
Software Engineer I (New Grad)
$106K - $115K *
Unlock your potential as you contribute to scalable software solutions, collaborating with cross-functional teams to enhance assessment systems. Gain hands-on experience in modern development practice...
1 week ago
HVAC District Sales Manager - MN, IA, ND, SD
$97K - $115K *
Unlock potential by driving sales growth and building relationships in the HVAC market. Support customers with training and expertise while managing a territory that includes MN, IA, ND, and SD. Colla...
1 week ago
$110K - $130K *
Engineer innovative solutions as you build and scale our platform, collaborating across the tech stack. Contribute to key decisions and shape our engineering culture in a dynamic, fast-paced environme...
1 week ago
$70K - $117K *
Lead the charge in optimizing provider networks and managing strategic projects. Collaborate cross-functionally to ensure timely delivery and enhance partnerships, driving success from initiation to c...
1 week ago
$75K - $100K *
Unlock your potential as you support institutional clients through onboarding, training, and engagement. Collaborate with cross-functional teams to enhance customer satisfaction and drive retention in...
1 week ago
Director, Product Management | Applied AI
$160K - $190K *
Lead and develop a team of Product Managers to drive AI-powered product strategy, governance, and investment decisions. Shape the organization's AI capabilities while ensuring responsible AI practices...
1 week ago
Dialysis Home Therapies Nurse (RN)
$74K - $99K *
Elevate your nursing career by coordinating home dialysis programs, ensuring top-notch patient care through collaboration and education. Join a dedicated team focused on improving lives with innovativ...
1 week ago
Senior Manager, State and Local Government Relations (Western US)
$150K - $268K *
Drive state and local government relations across 25 states, managing legislative efforts and stakeholder engagement to advance business goals. Collaborate with internal teams and external partners to...
1 week ago
$140K - $160K *
Drive your career with a leading Internal Audit team, overseeing risk-based audits, managing staff, and ensuring compliance. Collaborate with stakeholders to enhance controls and promote effective rem...
1 week ago
Senior Oncology Account Manager, Portland
$150K - $230K *
Empower your career by driving oncology product success and building impactful relationships with healthcare professionals. Lead strategic initiatives to enhance patient access and deliver innovative...
1 week ago
CyberArk SME / DevOps Engineer
$70K - $110K *
Elevate your career as a CyberArk SME/DevOps Engineer, implementing secure solutions for federal modernization. Leverage your expertise in privileged access management to drive best practices and enha...
1 week ago
Senior Oncology Account Manager, Cincinnati
$150K - $230K *
Transform your career by driving oncology product success and building impactful relationships with healthcare professionals. Leverage your expertise to enhance patient access and deliver innovative s...
1 week ago
Senior Oncology Account Manager, Los Angeles Central
$150K - $230K *
Unlock potential by driving oncology product success through strategic relationships and innovative solutions. Lead market engagement, exceed performance goals, and ensure patient access while embodyi...
1 week ago
Senior Oncology Account Manager, Columbus
$150K - $230K *
Drive impactful oncology product promotion by building strong relationships with key stakeholders, exceeding performance goals, and ensuring patient access to innovative therapies within your territor...
1 week ago
Senior Oncology Account Manager, Nashville
$150K - $230K *
Champion the promotion of oncology products, building strong relationships with healthcare professionals to enhance patient access and drive brand success in a competitive market. Leverage clinical ex...
1 week ago
Senior Oncology Account Manager, Chicago South
$150K - $230K *
Unlock potential by driving oncology product success through strategic relationships and innovative solutions. Collaborate with healthcare professionals to enhance patient access and exceed performanc...
1 week ago
Experiential Creative Director - Exhibit Activations - Remote
$110K - $130K *
Champion immersive experiences by leading creative teams to craft compelling narratives in healthcare and aerospace exhibitions, ensuring impactful audience engagement and innovative design solutions...
1 week ago
$95K - $115K *
Deliver innovative Appian solutions by developing, enhancing, and maintaining applications while supporting modernization initiatives in a collaborative Agile environment. Troubleshoot issues and ensu...
1 week ago
Senior Creative Project Manager
$82K - $229K *
Lead the charge in managing creative projects from inception to delivery, ensuring alignment with brand standards. Collaborate across teams to optimize workflows and maintain quality control for all a...
1 week ago
Senior Investment Designer (Rewards and Commerce)
$124K - $149K *
Reimagine player engagement by designing innovative reward systems that enhance gameplay experiences. Collaborate with a dynamic team to create compelling content that captivates and retains players i...
1 week ago
Staff Product Security Engineer
$150K - $180K *
Champion the security strategy for a cutting-edge platform, focusing on supply chain security, code scanning, and threat modeling. Collaborate with teams to enhance security practices and drive innova...
1 week ago
Staff Product Manager, Network Observability
$135K - $160K *
Lead the charge in shaping innovative Network Observability products, driving strategy from concept to launch. Collaborate with cross-functional teams to deliver solutions that empower operators to op...
1 week ago
Section Chief, Abdominal / Body Imaging
$300K - $350K *
Transform your career by leading a national body imaging service line, optimizing workflows, and enhancing clinical quality standards while mentoring a dedicated team of radiologists across multiple l...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.