Explore South Dakota Jobs Paying $100,000 or More

Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.

Find High-Paying Opportunities Across South Dakota

South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.

Explore South Dakota’s Major Job Markets

Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.

Build Your Next Career Move

Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.

Search South Dakota Jobs on Ladders

Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$110K - $130K *

Unlock potential by leading innovative demand generation strategies that drive pipeline growth and market engagement. Collaborate across departments to optimize campaigns and mentor teams, ensuring al...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$146K - $196K *

Transform genomic insights into clinical applications by designing automated solutions and integrating AI/ML approaches. Collaborate with cross-functional teams to enhance variant curation and ensure...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$185K - $312K *

Engineer the future of home shopping by developing a foundational AI model that integrates market dynamics, consumer behavior, and economic factors to enhance user experience and decision-making in re...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$110K - $130K *

Shape the future of secure software development by integrating security practices into engineering workflows, building automation tools, and conducting penetration tests to identify vulnerabilities an...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Join a team that's committed to operational excellence and strategic growth. Lead daily operations, drive profitability, and foster a high-performance culture while ensuring safety and quality in all...

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$95K - $105K *

Transform creative visions into tangible assets by managing the entire production lifecycle. Oversee timelines, quality control, and vendor relationships to ensure projects are delivered on-brand, on...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Media

$72K - $116K *

Engage in financial analysis and reporting, developing forecasts and insights. Collaborate across departments to enhance business outcomes and present findings to management, driving strategic decisio...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$170K - $200K *

Unlock potential by leading product strategy for organic discovery and AI visibility across a vast platform. Drive client success through innovative solutions, collaborating with engineering and desig...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $150K *

Unlock the potential of strategic accounts as you build lasting relationships, drive retention, and identify growth opportunities. Be the primary advocate for our major enterprise clients, ensuring sa...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$89K - $115K *

Shape innovative software solutions by designing, developing, and maintaining robust applications. Collaborate with cross-functional teams to enhance user experience and optimize application performan...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Unlock potential by driving business growth in the Geo division. Build relationships with engineers and contractors, educate on product offerings, and secure bidding opportunities. Remote work availab...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$135K - $160K *

Transform OEM partnerships by driving strategic growth and innovative solutions. Leverage market insights and relationship-building skills to negotiate impactful deals and collaborate with senior lead...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$120K - $145K *

Lead the charge in designing scalable, cloud-based SaaS solutions for Higher Education. Collaborate with cross-functional teams to translate institutional needs into actionable solutions, ensuring ali...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$109K - $197K *

Lead the design and implementation of MuleSoft integration solutions, focusing on API development and cloud deployments. Collaborate with teams to translate business needs into technical specification...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Business Services

$101K - $203K *

Transform product strategy by leading digital product development and enhancements. Collaborate with cross-functional teams to gather insights, prioritize initiatives, and drive innovation that meets...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $215K *

Lead the charge in developing a cutting-edge compliance program for consumer financial products. You'll oversee a team, drive strategy, and ensure adherence to regulations in a fast-paced, innovative...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$125K - $150K *

Advance the future of financial engineering by building a robust platform for pricing, billing, and revenue management in an AI-driven environment. Collaborate cross-functionally to automate processes...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Inspire patient recruitment strategies by leading a dynamic team, collaborating with senior management, and leveraging innovative tools to enhance enrollment across clinical trials while ensuring dive...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$205K - $256K *

Transform your career by leading Apollo's data strategy, ensuring the highest quality B2B data for GTM success. Drive product vision, collaborate cross-functionally, and enhance customer experiences t...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$133K - $150K *

Champion innovative finance solutions by owning core accounting operations, driving automation, and enhancing financial reporting. Collaborate across teams to build a scalable finance function that su...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$404K - $500K+*

Transform the Federal Civilian landscape by leading sales teams to drive adoption of cybersecurity and data solutions. Cultivate executive relationships, establish GTM strategies, and achieve multi-mi...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$235K - $291K *

Champion strategic leadership across diverse digital and marketing initiatives, guiding cross-disciplinary teams and fostering client relationships to drive impactful solutions and business growth in...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$150K - $180K *

Drive enterprise sales strategy for innovative agentic products, building relationships with key decision-makers. Collaborate with product and engineering teams to translate customer needs into compel...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$110K - $145K *

Optimize compensation strategies by providing expert advisory support, leading complex analyses, and enhancing program effectiveness. Collaborate with leaders to ensure alignment with business needs a...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$88K - $154K *

Engineer innovative Electronic Security Systems solutions for diverse clients, guiding projects from concept to construction. Collaborate with teams to ensure compliance with specifications and delive...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What South Dakota jobs on Ladders pay $100,000 or more?question toggle

    Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.

  • Which South Dakota cities have high-paying jobs?question toggle

    Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.

  • Are remote jobs available to South Dakota residents?question toggle

    Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.

  • How can I find senior-level jobs in South Dakota?question toggle

    Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.

  • Does Ladders verify South Dakota job listings?question toggle

    Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.