Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.
South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.
Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.
Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.
Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.
Average Salary: $119,100
Senior Demand Generation Manager
$110K - $130K *
Unlock potential by leading innovative demand generation strategies that drive pipeline growth and market engagement. Collaborate across departments to optimize campaigns and mentor teams, ensuring al...
1 week ago
Staff Bioinformatics Scientist, Clinical Applications
$146K - $196K *
Transform genomic insights into clinical applications by designing automated solutions and integrating AI/ML approaches. Collaborate with cross-functional teams to enhance variant curation and ensure...
1 week ago
Applied Research Scientist, World Model
$185K - $312K *
Engineer the future of home shopping by developing a foundational AI model that integrates market dynamics, consumer behavior, and economic factors to enhance user experience and decision-making in re...
1 week ago
$110K - $130K *
Shape the future of secure software development by integrating security practices into engineering workflows, building automation tools, and conducting penetration tests to identify vulnerabilities an...
1 week ago
General Manager - Ace Ready Mix
$100K - $120K *
Join a team that's committed to operational excellence and strategic growth. Lead daily operations, drive profitability, and foster a high-performance culture while ensuring safety and quality in all...
1 week ago
$95K - $105K *
Transform creative visions into tangible assets by managing the entire production lifecycle. Oversee timelines, quality control, and vendor relationships to ensure projects are delivered on-brand, on...
1 week ago
$72K - $116K *
Engage in financial analysis and reporting, developing forecasts and insights. Collaborate across departments to enhance business outcomes and present findings to management, driving strategic decisio...
Reposted 1 week ago
Staff Product Manager, Search and AI Visibility - US (Remote)
$170K - $200K *
Unlock potential by leading product strategy for organic discovery and AI visibility across a vast platform. Drive client success through innovative solutions, collaborating with engineering and desig...
1 week ago
National Enterprise Account Manager
$120K - $150K *
Unlock the potential of strategic accounts as you build lasting relationships, drive retention, and identify growth opportunities. Be the primary advocate for our major enterprise clients, ensuring sa...
Reposted 1 week ago
$89K - $115K *
Shape innovative software solutions by designing, developing, and maintaining robust applications. Collaborate with cross-functional teams to enhance user experience and optimize application performan...
Reposted 1 week ago
$95K - $115K *
Unlock potential by driving business growth in the Geo division. Build relationships with engineers and contractors, educate on product offerings, and secure bidding opportunities. Remote work availab...
1 week ago
Business Development Director, OEM Partnerships
$135K - $160K *
Transform OEM partnerships by driving strategic growth and innovative solutions. Leverage market insights and relationship-building skills to negotiate impactful deals and collaborate with senior lead...
1 week ago
Senior Solutions Architect, Pre-Sales (Banner or Colleague Exp Required) | Remote
$120K - $145K *
Lead the charge in designing scalable, cloud-based SaaS solutions for Higher Education. Collaborate with cross-functional teams to translate institutional needs into actionable solutions, ensuring ali...
1 week ago
Senior Mulesoft Developer (Technical Lead) - US Remote
$109K - $197K *
Lead the design and implementation of MuleSoft integration solutions, focusing on API development and cloud deployments. Collaborate with teams to translate business needs into technical specification...
Reposted 1 week ago
$101K - $203K *
Transform product strategy by leading digital product development and enhancements. Collaborate with cross-functional teams to gather insights, prioritize initiatives, and drive innovation that meets...
1 week ago
Head of Consumer and Lending Compliance
$150K - $215K *
Lead the charge in developing a cutting-edge compliance program for consumer financial products. You'll oversee a team, drive strategy, and ensure adherence to regulations in a fast-paced, innovative...
Reposted 1 week ago
Software Engineer, Money Platform
$125K - $150K *
Advance the future of financial engineering by building a robust platform for pricing, billing, and revenue management in an AI-driven environment. Collaborate cross-functionally to automate processes...
1 week ago
Senior Director, Patient Recruitment - Remote
$150K - $180K *
Inspire patient recruitment strategies by leading a dynamic team, collaborating with senior management, and leveraging innovative tools to enhance enrollment across clinical trials while ensuring dive...
1 week ago
Principal Product Builder, Data
$205K - $256K *
Transform your career by leading Apollo's data strategy, ensuring the highest quality B2B data for GTM success. Drive product vision, collaborate cross-functionally, and enhance customer experiences t...
1 week ago
$133K - $150K *
Champion innovative finance solutions by owning core accounting operations, driving automation, and enhancing financial reporting. Collaborate across teams to build a scalable finance function that su...
1 week ago
RVP, Sales - Splunk Federal Civilian
$404K - $500K+*
Transform the Federal Civilian landscape by leading sales teams to drive adoption of cybersecurity and data solutions. Cultivate executive relationships, establish GTM strategies, and achieve multi-mi...
1 week ago
$235K - $291K *
Champion strategic leadership across diverse digital and marketing initiatives, guiding cross-disciplinary teams and fostering client relationships to drive impactful solutions and business growth in...
1 week ago
$150K - $180K *
Drive enterprise sales strategy for innovative agentic products, building relationships with key decision-makers. Collaborate with product and engineering teams to translate customer needs into compel...
1 week ago
$110K - $145K *
Optimize compensation strategies by providing expert advisory support, leading complex analyses, and enhancing program effectiveness. Collaborate with leaders to ensure alignment with business needs a...
1 week ago
Electronic Security Systems Engineer
$88K - $154K *
Engineer innovative Electronic Security Systems solutions for diverse clients, guiding projects from concept to construction. Collaborate with teams to ensure compliance with specifications and delive...
1 week ago
What South Dakota jobs on Ladders pay $100,000 or more?
Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.
Which South Dakota cities have high-paying jobs?
Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.
Are remote jobs available to South Dakota residents?
Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.
How can I find senior-level jobs in South Dakota?
Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.
Does Ladders verify South Dakota job listings?
Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.