Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.
South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.
Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.
Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.
Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.
Average Salary: $119,100
Head of Consumer and Lending Compliance
$150K - $215K *
Lead the charge in developing a cutting-edge compliance program for consumer financial products. You'll oversee a team, drive strategy, and ensure adherence to regulations in a fast-paced, innovative...
Reposted 1 week ago
Software Engineer, Money Platform
$125K - $150K *
Advance the future of financial engineering by building a robust platform for pricing, billing, and revenue management in an AI-driven environment. Collaborate cross-functionally to automate processes...
1 week ago
Senior Director, Patient Recruitment - Remote
$150K - $180K *
Inspire patient recruitment strategies by leading a dynamic team, collaborating with senior management, and leveraging innovative tools to enhance enrollment across clinical trials while ensuring dive...
1 week ago
Principal Product Builder, Data
$205K - $256K *
Transform your career by leading Apollo's data strategy, ensuring the highest quality B2B data for GTM success. Drive product vision, collaborate cross-functionally, and enhance customer experiences t...
1 week ago
$133K - $150K *
Champion innovative finance solutions by owning core accounting operations, driving automation, and enhancing financial reporting. Collaborate across teams to build a scalable finance function that su...
1 week ago
RVP, Sales - Splunk Federal Civilian
$404K - $500K+*
Transform the Federal Civilian landscape by leading sales teams to drive adoption of cybersecurity and data solutions. Cultivate executive relationships, establish GTM strategies, and achieve multi-mi...
1 week ago
$235K - $291K *
Champion strategic leadership across diverse digital and marketing initiatives, guiding cross-disciplinary teams and fostering client relationships to drive impactful solutions and business growth in...
1 week ago
$150K - $180K *
Drive enterprise sales strategy for innovative agentic products, building relationships with key decision-makers. Collaborate with product and engineering teams to translate customer needs into compel...
1 week ago
$110K - $145K *
Optimize compensation strategies by providing expert advisory support, leading complex analyses, and enhancing program effectiveness. Collaborate with leaders to ensure alignment with business needs a...
1 week ago
Electronic Security Systems Engineer
$88K - $154K *
Engineer innovative Electronic Security Systems solutions for diverse clients, guiding projects from concept to construction. Collaborate with teams to ensure compliance with specifications and delive...
1 week ago
Process Improvement Consultant-Financial Services Facility Construction Program
$100K - $120K *
Transform business operations by identifying improvement opportunities, optimizing processes, and driving sustainable outcomes. Collaborate with stakeholders to enhance performance and support organiz...
1 week ago
Labor & Employment Counsel-Remote
$110K - $130K *
Drive impactful employment law solutions as a Virtual Office Counsel, managing administrative charges and litigation while collaborating with a skilled legal team in a flexible, remote environment foc...
Reposted 1 week ago
$80K - $90K *
Transform your marketing career by driving product strategies and campaigns. Collaborate with cross-functional teams to create compelling messaging and targeted programs that enhance customer engageme...
1 week ago
Account Executive, Mid Market (TOLA)
$152K - $190K *
Engage with mid-sized customers to drive IoT solutions, managing complex sales cycles and building relationships with key stakeholders. Your efforts will directly impact industries that keep our world...
1 week ago
$85K - $100K *
Drive financial excellence by owning month-end close, reconciliations, and management reporting. Collaborate with leadership to enhance processes and ERP systems, ensuring accuracy and compliance as t...
1 week ago
Manager, Value & Access Analytics - GTN Forensics - U.S. Remote
$124K - $169K *
Optimize cross-portfolio analytics to enhance Gross-to-Net performance, identify anomalies, and drive process improvements. Collaborate with diverse teams to deliver actionable insights and scalable r...
1 week ago
Senior Group Funding Associate
$83K *
Engage with group leaders to enhance fundraising efforts, ensuring compliance and support. Manage administrative functions, track spending, and foster collaboration across departments while promoting...
1 week ago
Control Systems Integrator III - Food & Beverage
$95K - $115K *
Transform manufacturing processes by designing and implementing advanced PLC/HMI control systems for food and beverage plants, ensuring optimal performance and efficiency through innovative automation...
1 week ago
$100K - $300K *
Unlock potential by driving enterprise growth in non-commercial foodservice technology. Own the full sales lifecycle, engage stakeholders, and deliver tailored solutions that enhance operational effic...
1 week ago
Control Systems Integrator III
$95K - $115K *
Unlock your potential by developing innovative control systems for diverse industries. Collaborate with clients to solve complex manufacturing challenges through automation and controls, ensuring effi...
1 week ago
Associate Director, Regulatory Science
$177K - $221K *
Champion regulatory excellence by leading cross-functional teams, ensuring compliance, and driving successful oncology drug development through strategic planning and expert guidance...
1 week ago
Manager - Software Development Engineering S 4D
$80K - $100K *
Unlock potential by leading a dynamic team of developers to deliver high-quality software solutions, collaborating with stakeholders, and driving strategic project initiatives while fostering a cultur...
1 week ago
Principal Quality Assurance Specialist, External Manufacturing
$150K - $190K *
Champion quality assurance excellence in GMP for drug substance and products, overseeing compliance and methodologies. Collaborate to ensure regulatory adherence while maintaining operational efficien...
Reposted 1 week ago
$109K - $145K *
Contribute to the development of a cloud storage solution, designing and delivering features for a medical imaging platform. Collaborate within an Agile team, taking ownership of the development lifec...
1 week ago
$80K - $90K *
Join a dynamic team to drive product marketing and ABM strategies, enhancing customer engagement and market presence through compelling messaging and targeted campaigns that foster growth and awarenes...
1 week ago
What South Dakota jobs on Ladders pay $100,000 or more?
Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.
Which South Dakota cities have high-paying jobs?
Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.
Are remote jobs available to South Dakota residents?
Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.
How can I find senior-level jobs in South Dakota?
Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.
Does Ladders verify South Dakota job listings?
Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.