Explore South Dakota Jobs Paying $100,000 or More

Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.

Find High-Paying Opportunities Across South Dakota

South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.

Explore South Dakota’s Major Job Markets

Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.

Build Your Next Career Move

Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.

Search South Dakota Jobs on Ladders

Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$190K - $267K *

Transform safety enforcement through data science by developing models and systems that detect and mitigate abuse. Collaborate across teams to translate policies into actionable insights, ensuring eff...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Media

$120K - $170K *

Transform enterprise software systems by leading design and development efforts, ensuring scalable, secure applications that meet federal mission needs while mentoring engineers and driving best pract...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$66K - $99K *

Play a key role in delivering exceptional outpatient nursing care by assessing, planning, and implementing individualized patient care in collaboration with a multidisciplinary team, ensuring adherenc...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Drive the branded merchandise function, overseeing vendor sourcing, production management, and budget accountability. Ensure timely delivery and quality control while collaborating cross-functionally...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Food & Beverages

$110K - $130K *

Lead the charge in driving regional sales growth by developing strategic plans, managing budgets, and fostering strong customer relationships. Collaborate with cross-functional teams to optimize perfo...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$75K - $110K *

Optimize the claims resolution process for commercial property and casualty claims. Collaborate with internal teams and stakeholders to enhance claims handling efficiency and effective communication...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$128K - $177K *

Innovate solutions as a System Architect, leading design and implementation of ASTRO systems. Collaborate with cross-functional teams to enhance communication technologies, ensuring seamless integrati...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$184K - $356K *

Elevate the future of autonomous software systems by building and optimizing AI agent evaluation frameworks, enhancing usability, reliability, and performance with a collaborative engineering team ded...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Drive client engagement and solution development in digital banking, leveraging expertise in banking technology and pre-sales. Collaborate with teams to deliver tailored solutions and impactful demons...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$135K - $170K *

Accelerate growth by managing strategic healthcare accounts, driving new business, and enhancing relationships. Collaborate with cross-functional teams to address complex identity challenges and deliv...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Empower growth by leading Oracle Managed Services sales and strategy. Drive new business, build executive relationships, and enhance service offerings while collaborating with cross-functional teams t...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Staffing

$192K - $310K *

Lead the charge in designing and implementing innovative sales compensation programs that align with business goals. Collaborate with cross-functional teams to ensure compliance, drive performance, an...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $145K *

Transform client experiences by leading the design and implementation of Oracle HCM Cloud solutions. Collaborate with teams to ensure scalable, reliable, and high-performance technical architectures t...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Staffing

$120K - $145K *

Grow your career with a dynamic role leading Oracle Cloud transformation programs. Oversee multiple projects across CX, ERP, and HCM platforms, ensuring alignment with business objectives while managi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Staffing

$110K - $130K *

Drive successful Oracle Cloud HCM implementations by leading Core HR solutions, collaborating with stakeholders, and ensuring best practices for HR operations. Provide functional leadership and mentor...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Staffing

$162K - $228K *

Transform the Ad Tech landscape by leading cross-functional teams to ensure seamless delivery and execution of complex technology portfolios, driving strategic initiatives and fostering collaboration...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$180K - $215K *

Drive regional success by leading launch execution and building high-performing teams. Foster customer relationships and ensure alignment with corporate goals in a fast-paced, entrepreneurial environm...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Transform your career by leading regional sales efforts for a groundbreaking product. Drive performance, build a high-performing team, and engage with key healthcare providers in a fast-paced, entrepr...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Transform regional sales performance by leading a high-impact team, executing strategic launches, and fostering key customer relationships in a dynamic, fast-paced environment. Drive accountability an...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Shape the future of healthcare by leading regional sales efforts, driving product launch success, and building high-performing teams. Collaborate cross-functionally to achieve sales goals and foster s...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $133K *

Champion innovative solutions by collaborating with cross-functional teams to develop scalable, cloud-native applications. Leverage your full-stack expertise to modernize systems and deliver high-valu...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$80K - $85K *

Grow your career with a dynamic team focused on client success, managing relationships, and delivering tailored solutions. Drive satisfaction and retention while collaborating across departments to en...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Lead national physician engagement and business development for a fertility pharmacy, managing a multi-layered team to drive growth and build executive relationships across clinics and provider networ...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$162K - $224K *

Champion innovative MRI solutions by leveraging clinical expertise and project management skills to enhance healthcare performance and patient outcomes. Collaborate with teams to optimize workflows an...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $145K *

Join a dynamic team to lead connectivity projects for leased data centers, ensuring compliance with standards and managing cross-functional collaboration from site assessment to operational handoff. D...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What South Dakota jobs on Ladders pay $100,000 or more?question toggle

    Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.

  • Which South Dakota cities have high-paying jobs?question toggle

    Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.

  • Are remote jobs available to South Dakota residents?question toggle

    Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.

  • How can I find senior-level jobs in South Dakota?question toggle

    Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.

  • Does Ladders verify South Dakota job listings?question toggle

    Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.