Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.
South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.
Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.
Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.
Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.
Average Salary: $121,112
Spend Management Account Executive
$85K - $113K *
Engage with finance leaders to drive growth in our client base, leveraging your FinTech expertise. Collaborate with a dynamic sales team to refine strategies and exceed sales quotas while promoting in...
1 week ago
$66K - $99K *
Champion patient care by utilizing your nursing expertise to lead clinical teams, coordinate care, and mentor staff. Engage in effective communication and critical thinking to enhance patient outcomes...
1 week ago
Director, Nursing and Clinical Services
$100K - $120K *
Lead the charge in delivering high-quality rural healthcare by overseeing nursing and clinical operations. Engage with staff and patients to ensure compliance and enhance patient care standards in a d...
1 week ago
Technical Solutions Manager - Life Sciences
$135K - $160K *
Lead the charge in delivering innovative DCS solutions for Life Sciences. Serve as the technical expert, driving automation strategies and ensuring compliance with regulations to support growth and ex...
Reposted 1 week ago
Sales Development Partner - Entry Level to Leadership
$75K - $100K *
Elevate partnerships with diverse businesses, understanding their needs and delivering tailored solutions while fostering growth and leadership opportunities in a dynamic, field-focused environment...
Reposted 1 week ago
Technical Support Manager, Billing - Remote US, ET or CT
$75K - $100K *
Manage day-to-day billing operations and client support in the energy sector. Lead client interactions, troubleshoot technical issues, and collaborate with internal teams to enhance service delivery a...
1 week ago
$69K - $101K *
Champion the reliability of automated systems by providing expert technical support, troubleshooting complex issues, and collaborating cross-functionally to ensure operational excellence and seamless...
1 week ago
Principal/Sr Principal Supplier Mission Assurance Engineer - 19548
$94K - $141K *
Join a dynamic team to oversee supplier quality assurance, manage compliance, and engage in supplier evaluations. Leverage your expertise to ensure product integrity while collaborating directly with...
Reposted 1 week ago
Customer Care Veterinary Technician
$72K - $104K *
Unlock your potential by delivering exceptional customer support in veterinary care. Engage with clients, resolve inquiries, and ensure compliance with industry standards while collaborating with inte...
1 week ago
Manager Regulatory Intelligence
$120K - $180K *
Shape the future of regulatory intelligence by leading cross-functional teams, managing global surveillance workstreams, and translating complex regulations into actionable insights for stakeholders a...
1 week ago
$130K - $200K *
Lead the charge in driving sales performance through strategic account management, collaboration, and innovative program execution within the C&S hospital sector, while fostering relationships and del...
1 week ago
Enterprise Account Executive II - NorthWest
$130K - $150K *
Drive enterprise growth by leading complex sales cycles and collaborating with cross-functional teams to deliver innovative cybersecurity solutions. Shape the future of security while exceeding sales...
1 week ago
Sr Director Analyst, Data Management for AI Enablement
$172K - $202K *
Champion innovative insights and strategies as a Senior Director, driving impactful research and analysis to empower clients globally. Engage with stakeholders to deliver actionable advice and elevate...
1 week ago
$80K - $85K *
Elevate your career by managing key client relationships and driving account growth. Collaborate with cross-functional teams to deliver impactful training programs, ensuring client satisfaction and me...
1 week ago
Workers Compensation Claims Administrator
$80K - $95K *
Engage as a claims advocate, collaborating with Risk Advisors to resolve workers' compensation claims. Build trusted relationships and provide expert guidance to clients, ensuring prompt and fair hand...
1 week ago
$127K - $205K *
Join a dynamic team to drive pre-sales engagement, showcasing innovative solutions that address complex client needs through technical expertise and compelling presentations. Collaborate across depart...
1 week ago
Associate Director, Strategic Accounts (Texas)
$135K - $160K *
Contribute to the success of a dynamic sales team by managing key accounts, leading a team of specialists, and driving advocacy for innovative hematology solutions. Collaborate cross-functionally to e...
1 week ago
$100K - $120K *
Drive digital advertising revenue by building relationships with media agencies and brands. Manage the full sales cycle, develop customized solutions, and consistently exceed revenue targets in the Ne...
1 week ago
Program Specialist, Care Management
$74K - $119K *
Transform healthcare delivery by coordinating strategic programs that enhance clinical and operational excellence. Collaborate with diverse teams to implement innovative solutions, ensuring compliance...
1 week ago
Professional (Senior) Sales Representative, Pain - Ann Arbor, MI
$100K - $162K *
Join us to develop and implement strategic sales plans, build customer relationships, and achieve sales goals while adhering to ethical practices. Make a positive impact in the pharmaceutical industry...
Reposted 1 week ago
$82K - $112K *
Shape compelling product narratives by leveraging market insights and AI tools. Collaborate cross-functionally to drive go-to-market strategies, ensuring impactful messaging and training materials tha...
1 week ago
$80K - $102K *
Contribute to the design of user-centric digital products across platforms, collaborating with cross-functional teams to create high-fidelity prototypes and workflows that enhance user experience and...
1 week ago
Senior Product Builder, Partner Integrations
$122K - $180K *
Accelerate product development by defining, designing, and prototyping features for partner integrations, leveraging AI tools and user feedback to enhance payment processing solutions and maintain com...
1 week ago
Patient and Site Engagement Lead (US/UK)
$90K - $178K *
Transform the patient engagement landscape in clinical trials by developing and delivering strategic support initiatives. Partner with diverse stakeholders to enhance participation and optimize patien...
Reposted 1 week ago
Senior Project Management (Rare/Renal)
$128K - $254K *
Oversee and manage large-scale, multi-national projects, ensuring successful delivery through direct team leadership and cross-functional collaboration, while maintaining high quality and financial pe...
Reposted 1 week ago
What South Dakota jobs on Ladders pay $100,000 or more?
Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.
Which South Dakota cities have high-paying jobs?
Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.
Are remote jobs available to South Dakota residents?
Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.
How can I find senior-level jobs in South Dakota?
Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.
Does Ladders verify South Dakota job listings?
Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.