Explore South Dakota Jobs Paying $100,000 or More

Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.

Find High-Paying Opportunities Across South Dakota

South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.

Explore South Dakota’s Major Job Markets

Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.

Build Your Next Career Move

Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.

Search South Dakota Jobs on Ladders

Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $121,112

Sort By: Relevance

$80K - $95K *

Lead the charge in program management excellence, ensuring seamless operations and compliance across diverse teams while supporting critical Air Force contract initiatives and rapid-response readiness...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$90K - $110K *

Drive the successful execution of multiple e-discovery projects, collaborating with legal teams and mentoring junior staff. Ensure quality standards, manage budgets, and maintain client relationships...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$120K - $145K *

Drive the future of AI & Analytics by leading client relationships, providing strategic guidance, and delivering innovative solutions. Leverage your expertise to enhance service delivery and ensure al...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$120K - $150K *

Accelerate progress at the forefront of newborn health by leading strategic initiatives, managing multi-country programs, and driving impactful interventions to reduce neonatal mortality and stillbirt...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$85K - $100K *

Help us optimize Epic applications by leading projects, troubleshooting issues, and ensuring seamless integration. Collaborate with teams to enhance workflows and provide expert support, all while mai...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Lead the charge in building strategic relationships with key travel agencies, optimizing settlement operations, and enhancing distribution technologies to drive efficiency and growth in the travel eco...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$190K - $300K *

Build strategic relationships with scientific leaders to drive innovation in Pulmonary Hypertension. Engage in scientific exchange, support research initiatives, and enhance understanding of therapeut...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$67K - $100K *

Drive operational excellence by supporting the development and maintenance of standardized playbooks, SOPs, and workflows. Collaborate with cross-functional teams to ensure clarity and consistency in...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$112K - $236K *

Drive strategic decision-making by evaluating investment alternatives and lifecycle opportunities. Collaborate with cross-functional teams to optimize portfolio value and support program planning thro...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Lead the charge in building a secure, self-service developer sandbox on Azure, delivering non-persistent desktops and managing the entire stack from landing zone to golden image while ensuring complia...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $180K *

Accelerate your career by leading Army business development, transforming priorities into funded opportunities. Drive strategy from engagement to award, collaborating with key stakeholders to ensure s...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$157K - $185K *

Analyze and own AI Security sales in your territory, driving the full sales cycle from prospecting to closing. Collaborate with Account Executives to penetrate enterprise accounts and shape product of...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$183K - $220K *

Lead talent acquisition and relations, managing a team to secure top instructors. Drive strategic partnerships and streamline operations while maintaining high-profile relationships and ensuring succe...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Education, Government & Non-Profit

$75K - $90K *

Drive innovative advertising strategies by transforming customer insights and performance data into compelling creative content. Collaborate with cross-functional teams to enhance product visibility a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

$125K - $145K *

Drive customer success by optimizing technical adoption of the AIOps platform, ensuring enterprise clients achieve measurable outcomes through strategic partnerships and expert guidance in incident ma...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$126K - $200K *

Lead technical solutions architecture for HPE storage platforms, guiding partners and sales teams in developing resilient infrastructure solutions. Drive engagement, enablement, and strategic initiati...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$180K - $220K *

Transform global in vitro scientific operations by leading expansive teams and driving innovation across oncology and immunology studies. Ensure operational excellence, harmonize multi-site workflows...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$165K - $260K *

Drive the development of an intelligent content delivery network, optimizing web performance through cutting-edge infrastructure and AI. Collaborate with a lean team to transform complex problems into...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$120K - $145K *

Join a team that's pioneering the deployment of scalable AI systems, focusing on building robust APIs, optimizing infrastructure, and ensuring reliable operations in a dynamic environment. Drive innov...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $150K *

Transform the landscape of programmatic media sales by driving new business with mid-sized agencies. Leverage first-party data solutions to enhance marketing strategies and build lasting relationships...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Innovate and lead the MyGeotab workflows, ensuring usability and reliability while driving evolution and collaboration across product domains to enhance customer experience and operational efficiency...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Transportation

$120K - $140K *

Transform your career by leading complex design change projects from inception to execution. Collaborate with cross-functional teams, manage substantial budgets, and drive innovation in a fast-paced e...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$145K - $150K *

Grow your career with a collaborative team focused on public health solutions. As a Senior Salesforce Developer, you'll leverage your expertise to enhance health department systems nationwide within a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$262K - $394K *

Accelerate progress at Clio Phones by leading the growth of a cloud-native VoIP platform for law firms. Own P&L, build operational plans, and drive market strategy while managing cross-functional team...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Legal & Accounting

$105K - $163K *

Accelerate progress at the forefront of enterprise security solutions, driving revenue growth through strategic account management and collaboration with internal teams to enhance customer relationshi...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What South Dakota jobs on Ladders pay $100,000 or more?question toggle

    Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.

  • Which South Dakota cities have high-paying jobs?question toggle

    Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.

  • Are remote jobs available to South Dakota residents?question toggle

    Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.

  • How can I find senior-level jobs in South Dakota?question toggle

    Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.

  • Does Ladders verify South Dakota job listings?question toggle

    Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.