Explore South Dakota Jobs Paying $100,000 or More

Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.

Find High-Paying Opportunities Across South Dakota

South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.

Explore South Dakota’s Major Job Markets

Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.

Build Your Next Career Move

Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.

Search South Dakota Jobs on Ladders

Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $121,112

Sort By: Relevance

$80K - $95K *

Unlock potential by managing system design, build, and support for applications, ensuring optimal functionality and user satisfaction while collaborating across teams to enhance workflows and resolve...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$115K - $155K *

Empower your career by ensuring the quality and performance of Salesforce solutions in Government Cloud environments. Collaborate with cross-functional teams to validate requirements and enhance testi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$106K - $284K *

Elevate your career by leading the design and development of innovative healthcare platforms. Collaborate with cross-functional teams to deliver scalable, secure applications that enhance user experie...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$210K *

Join a dynamic telemedicine team to deliver high-quality, patient-centered care across South Dakota. Enjoy flexible scheduling while managing diverse clinical cases, including primary and urgent care...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$237K - $275K *

Join a team that's redefining client partnerships by owning strategic accounts, driving revenue growth, and ensuring client satisfaction through integrated solutions and executive relationships across...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Media

$150K - $180K *

Champion global physical security and resiliency initiatives by providing strategic leadership to enhance safety for employees and assets while driving compliance across all company operations and thi...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Partner with us to drive innovative solutions as a Principal Architect, engaging in multi-faceted pre-sales and delivery efforts. Collaborate with teams and clients to enhance customer experiences and...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$130K - $195K *

Join a dynamic AI Automation team to design and deliver production-grade AI agents and workflows, enhancing operational efficiency across the organization while solving complex business challenges wit...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$96K - $130K *

Join a dynamic team to shape innovative fundraising tools that empower progressive campaigns and nonprofits. Leverage modern technologies to enhance election readiness and compliance, while mentoring...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$144K - $200K *

Transform public safety sales by leading a regional team, enhancing performance, and driving success through effective coaching and recruitment. Collaborate across departments to build a predictable p...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$90K - $110K *

Drive quality assurance for ICT cabling infrastructure across 700+ Army Reserve sites. Collaborate with engineering teams and contractors to ensure compliance with technical standards and deliver exce...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Champion the modernization of SLED organizations by guiding them through technical evaluations and deployments of GitLab's DevSecOps platform, ensuring compliance and enhancing service delivery across...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Join a team that's redefining product management by leading cross-product initiatives and shared services. Collaborate with diverse teams to drive innovation, enhance platform capabilities, and delive...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$105K - $150K *

Champion integrated marketing campaigns that drive pipeline growth in the Business & Government sector. Collaborate across teams to execute strategies, optimize performance, and leverage AI for innova...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$90K *

Lead the charge in driving field marketing initiatives that convert events and partnerships into qualified sales opportunities, collaborating closely with sales teams to optimize pipeline contribution...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $140K *

Join a team that's driving sales success by engaging clients, managing opportunities, and closing deals. Leverage your expertise to present solutions and collaborate with internal teams to achieve rev...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$87K - $162K *

Engage in transformative process improvement initiatives, collaborating with leaders to analyze and redesign workflows. Drive efficiency and quality across multiple business units, creating lasting va...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$56K - $104K *

Lead the charge in driving growth and retention by serving as a strategic partner to financial professionals. Utilize consultative sales expertise to deliver tailored solutions and enhance client succ...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$68K - $126K *

Elevate client success by serving as a strategic partner to financial professionals, driving growth and retention through consultative sales expertise and relationship management across your assigned...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$56K - $104K *

Elevate your career by serving as a strategic partner to financial professionals, driving growth and client success through consultative sales and relationship management across your territory. Make a...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Deliver strategic program management by coordinating activities, assessing risks, and ensuring stakeholder alignment. Leverage expertise to enhance business performance and drive compliance while guid...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$158K - $213K *

Oversee day-to-day accounting and treasury operations, ensuring accuracy and compliance. Lead month-end close processes, refine internal controls, and develop a high-performing team while integrating...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$203K - $319K *

Lead and optimize commercial operations to drive growth, enhance revenue strategies, and streamline processes. Collaborate with cross-functional teams to ensure effective execution of sales initiative...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$187K - $260K *

Lead the charge in shaping our marketing technology ecosystem, driving product strategy and team development while enhancing workflows and cross-channel capabilities for data-driven marketing success...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$80K - $95K *

Empower scientific innovation by providing expert installation and maintenance of advanced analytical equipment. Build strong customer relationships while resolving complex issues and ensuring optimal...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What South Dakota jobs on Ladders pay $100,000 or more?question toggle

    Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.

  • Which South Dakota cities have high-paying jobs?question toggle

    Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.

  • Are remote jobs available to South Dakota residents?question toggle

    Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.

  • How can I find senior-level jobs in South Dakota?question toggle

    Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.

  • Does Ladders verify South Dakota job listings?question toggle

    Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.