Explore South Dakota Jobs Paying $100,000 or More

Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.

Find High-Paying Opportunities Across South Dakota

South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.

Explore South Dakota’s Major Job Markets

Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.

Build Your Next Career Move

Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.

Search South Dakota Jobs on Ladders

Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $121,112

Sort By: Relevance

$120K - $145K *

Unlock potential by leading the product lifecycle for innovative battery cabinet solutions. Drive market competitiveness and collaborate with cross-functional teams to meet customer needs in critical...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$169K - $185K *

Champion the design and delivery of integrations and APIs, collaborating with cross-functional teams to create secure, scalable, and user-friendly developer experiences that drive business impact and...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$120K - $145K *

Partner with us to drive technical sales success by leveraging your expertise in cloud and container technologies. Cultivate relationships, conduct demos, and secure wins while collaborating with our...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$180K - $220K *

Drive the future of healthcare operations by leading a $300M portfolio, fostering physician partnerships, and executing growth strategies while managing financial and operational performance for a dyn...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$100K - $115K *

Advance the payroll function for a diverse workforce, ensuring compliance and accuracy across multiple states. This hands-on role requires expertise in payroll systems and regulations, driving process...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$110K - $130K *

Accelerate progress at key global brand relationships in personal care. Manage diverse accounts, develop sales strategies, and collaborate cross-functionally to drive growth and enhance customer exper...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$105K - $157K *

Drive operational excellence by overseeing O&M activities and capital upgrades for power generation assets, ensuring compliance with safety and regulatory standards while optimizing resources and mana...

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$120K - $150K *

Engage top talent by leading full-cycle recruiting efforts, partnering with hiring managers to create effective hiring strategies, and fostering a positive candidate experience in both English and Spa...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$190K - $220K *

Champion impactful scientific engagement by building relationships with key stakeholders, translating clinical data into actionable insights, and driving prelaunch strategies in a dynamic environment...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$111K - $159K *

Lead clinical operations in review of medical certifications for leave requests. Build and manage a dedicated team, standardize workflows, and ensure compliance while driving continuous improvements i...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$161K - $210K *

Elevate workforce management by leading recruitment, onboarding, and performance strategies. Drive clinician readiness and productivity while ensuring quality care through data-driven decision-making...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$180K *

Innovate your career as a Principal Data Engineer, designing cutting-edge data infrastructure and lakehouse solutions. Leverage modern AI tools to enhance performance and quality while collaborating w...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$85K - $105K *

Lead the charge in optimizing HubSpot for RevOps clients, enhancing their marketing and sales strategies through tailored solutions, automation, and expert guidance while collaborating with cross-func...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $150K *

Shape the future of higher education by leading strategic initiatives and government affairs. Collaborate across teams to drive revenue opportunities and influence policy, ensuring impactful solutions...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $160K *

Unlock potential by guiding organizations through digital transformation with your expertise in AI-powered DevSecOps. Collaborate with cross-functional teams to drive successful platform adoption and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $140K *

Unlock potential by designing and optimizing Power BI solutions, collaborating with stakeholders to enhance reporting and analytics capabilities in a fully remote environment. Drive data accuracy and...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Staffing

$110K - $130K *

Optimize marketing workflows by developing AI tools that enhance productivity across teams. Collaborate closely with stakeholders to build, maintain, and support innovative solutions that drive effici...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$251K - $369K *

Champion a data-driven culture by leading global analytics initiatives that transform insights into actionable strategies, enhancing decision-making across commercial domains and driving measurable bu...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Retail & Consumer Goods

$222K - $278K *

Drive strategic sales initiatives for AI Products, partnering with enterprise accounts to maximize value and ROI. Collaborate with cross-functional teams to shape product offerings and ensure successf...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$164K - $246K *

Collaborate with cross-functional teams to translate cloud requirements into actionable product strategies, ensuring technical excellence and successful implementations in complex environments...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$125K - $150K *

Elevate your legal career by leading contract negotiations and leveraging AI to enhance deal-making efficiency. Collaborate with teams to refine processes and ensure quality execution, making a signif...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$195K - $270K *

Lead a dynamic team of analysts and data scientists to optimize marketing strategies, driving impactful insights and experimentation across channels to enhance growth and performance metrics for the o...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$85K - $106K *

Drive acceptance testing and commissioning in substations and PV facilities. Ensure safety, troubleshoot issues, and prepare documentation while traveling extensively to various job sites. Collaborate...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$135K - $160K *

Elevate your career by driving strategic programs that enhance our Extensibility platform. Collaborate across teams to shape product roadmaps and ensure successful launches while addressing complex cu...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$140K - $180K *

Accelerate progress at the intersection of Treasury and Accounting, managing cash forecasting, customer collections, and disbursements. Collaborate with cross-functional teams to ensure financial inte...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What South Dakota jobs on Ladders pay $100,000 or more?question toggle

    Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.

  • Which South Dakota cities have high-paying jobs?question toggle

    Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.

  • Are remote jobs available to South Dakota residents?question toggle

    Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.

  • How can I find senior-level jobs in South Dakota?question toggle

    Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.

  • Does Ladders verify South Dakota job listings?question toggle

    Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.