Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.
South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.
Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.
Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.
Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.
Average Salary: $121,112
$125K - $150K *
Elevate your career by leading civil site projects in the energy sector. Collaborate with a dynamic team to design, coordinate, and manage impactful utility projects while ensuring compliance with loc...
1 week ago
Project Leadership - Biotech (clinical trials) -Dermatology - Home Based
$110K - $130K *
Drive excellence in global clinical study leadership across various therapeutic areas. Collaborate with teams to deliver projects on time and within budget while exceeding client expectations...
Reposted 1 week ago
Principal Product Manager, Buyer Products
$150K - $180K *
Join a team that's redefining the buyer experience in B2B software. As a Principal Product Manager, you'll lead strategy, drive product delivery, and enhance buyer trust across multiple platforms, ens...
1 week ago
Sr. Medical Science Liaison- Appalachia Region
$166K - $205K *
Elevate your career as a Senior Medical Science Liaison, driving scientific exchange and collaboration with healthcare providers in oncology. Build relationships, support clinical initiatives, and con...
1 week ago
Director, Care Delivery Learning & Development
$161K - $202K *
Unlock potential by leading a dynamic Learning & Development team to enhance clinical and non-clinical training programs, ensuring high-quality patient care through innovative strategies and scalable...
1 week ago
SMB Account Executive - Sales, New Logo
$85K - $90K *
Engage with SMB accounts to build pipeline and close value-driven deals. Own your territory, manage sales cycles, and leverage data to drive results. Collaborate across teams to connect solutions with...
1 week ago
Partner 20, Social Media Lead, Frontier
$199K - $232K *
Unlock potential by driving social media strategy and engagement across diverse platforms. Collaborate with teams to create compelling content, analyze performance, and enhance brand presence while ad...
1 week ago
$80K - $95K *
Empower growth by developing strategic relationships with biotech and pharma clients. Drive market awareness and increase RFPs through collaboration with the business development team, leveraging your...
1 week ago
Procurement Manager, Process & Policy
$93K - $159K *
Advance your career by developing and standardizing Procurement processes that enhance compliance and efficiency. Collaborate with cross-functional teams to create clear documentation and governance p...
1 week ago
$115K - $165K *
Join a team that's transforming data into actionable insights through advanced statistical methodologies and machine learning, driving innovation in media measurement and analytics across diverse busi...
1 week ago
$125K - $150K *
Unlock potential by leading a nationwide acquisition program that enhances healthcare for American Indian and Alaska Native communities. Drive strategic direction, inspire a high-performing team, and...
1 week ago
$110K - $130K *
Elevate your career by implementing and supporting AWS cloud solutions in a dynamic environment. Collaborate with experts to optimize performance and ensure secure, scalable infrastructure for federal...
1 week ago
Application Packaging Engineer
$116K - $122K *
Deliver reliable application packaging solutions for a large federal IT environment. Collaborate with stakeholders to gather requirements and ensure seamless deployment across thousands of endpoints...
1 week ago
Senior Service Delivery Manager
$96K - $145K *
Transform service delivery for complex accounts by ensuring SLAs and KPIs are met. Lead governance, performance management, and continuous improvement initiatives while building trusted relationships...
1 week ago
Insights Manager - Health & Life Sciences (Remote, US-based only)
$75K - $90K *
Unlock potential by leading data analysis and storytelling efforts, ensuring insights meet client needs. Collaborate with teams to deliver actionable reports and maintain high-quality standards throug...
1 week ago
$80K - $95K *
Drive your career forward by cultivating client relationships and exceeding sales goals. As a key player, you'll develop marketing strategies, engage decision-makers, and provide tailored solutions to...
1 week ago
$155K - $241K *
Join us to shape the future of platform engineering by driving strategic initiatives, influencing organizational architecture, and enhancing developer experience across a multi-cloud environment. Your...
1 week ago
$225K - $250K *
Transform operations by leading a diverse team to enhance profitability and efficiency across multiple sites, while building strategic relationships with clients and driving growth initiatives in the...
1 week ago
$90K - $108K *
Drive successful project execution by managing customer projects from quotation to completion. Collaborate with teams and stakeholders to ensure timely delivery, quality standards, and customer satisf...
1 week ago
$195K - $215K *
Lead the charge in brand strategy, inspiring teams and fostering innovative solutions in a dynamic healthcare advertising environment, focused on advancing compelling communications and effective clie...
Reposted 1 week ago
$123K - $172K *
Join our dynamic team to tackle real challenges in SaaS management, enhancing IT and Security ecosystems. Collaborate with talented professionals to build impactful software while leveraging AI for ef...
1 week ago
Key Account Director, Corrections
$144K - $200K *
Help us lead a national sales team focused on public safety solutions. Drive recruitment, coaching, and team performance to enhance sales effectiveness in the corrections sector, while collaborating a...
1 week ago
Senior MES Consultant/ MES Lead Remote with Travel
$110K - $130K *
Lead the design and implementation of Manufacturing Execution Systems (MES) in the biotech and pharmaceutical sectors, ensuring effective integration and documentation while fostering strong client re...
1 week ago
$128K - $153K *
Join a team that's shaping the future of technology by delivering impactful software solutions. Collaborate on innovative projects, optimize data operations, and enhance user experiences while support...
1 week ago
$95K - $115K *
Lead and enhance day-to-day accounting operations, focusing on accounts payable, receivable, and cash management. Collaborate with cross-functional teams to ensure accurate, timely transactions while...
1 week ago
What South Dakota jobs on Ladders pay $100,000 or more?
Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.
Which South Dakota cities have high-paying jobs?
Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.
Are remote jobs available to South Dakota residents?
Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.
How can I find senior-level jobs in South Dakota?
Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.
Does Ladders verify South Dakota job listings?
Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.