Explore South Dakota Jobs Paying $100,000 or More

Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.

Find High-Paying Opportunities Across South Dakota

South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.

Explore South Dakota’s Major Job Markets

Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.

Build Your Next Career Move

Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.

Search South Dakota Jobs on Ladders

Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $121,112

Sort By: Relevance

$125K - $150K *

Elevate your career by leading civil site projects in the energy sector. Collaborate with a dynamic team to design, coordinate, and manage impactful utility projects while ensuring compliance with loc...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$110K - $130K *

Drive excellence in global clinical study leadership across various therapeutic areas. Collaborate with teams to deliver projects on time and within budget while exceeding client expectations...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Join a team that's redefining the buyer experience in B2B software. As a Principal Product Manager, you'll lead strategy, drive product delivery, and enhance buyer trust across multiple platforms, ens...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$166K - $205K *

Elevate your career as a Senior Medical Science Liaison, driving scientific exchange and collaboration with healthcare providers in oncology. Build relationships, support clinical initiatives, and con...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$161K - $202K *

Unlock potential by leading a dynamic Learning & Development team to enhance clinical and non-clinical training programs, ensuring high-quality patient care through innovative strategies and scalable...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$85K - $90K *

Engage with SMB accounts to build pipeline and close value-driven deals. Own your territory, manage sales cycles, and leverage data to drive results. Collaborate across teams to connect solutions with...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$199K - $232K *

Unlock potential by driving social media strategy and engagement across diverse platforms. Collaborate with teams to create compelling content, analyze performance, and enhance brand presence while ad...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Empower growth by developing strategic relationships with biotech and pharma clients. Drive market awareness and increase RFPs through collaboration with the business development team, leveraging your...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$93K - $159K *

Advance your career by developing and standardizing Procurement processes that enhance compliance and efficiency. Collaborate with cross-functional teams to create clear documentation and governance p...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$115K - $165K *

Join a team that's transforming data into actionable insights through advanced statistical methodologies and machine learning, driving innovation in media measurement and analytics across diverse busi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$125K - $150K *

Unlock potential by leading a nationwide acquisition program that enhances healthcare for American Indian and Alaska Native communities. Drive strategic direction, inspire a high-performing team, and...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Elevate your career by implementing and supporting AWS cloud solutions in a dynamic environment. Collaborate with experts to optimize performance and ensure secure, scalable infrastructure for federal...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$116K - $122K *

Deliver reliable application packaging solutions for a large federal IT environment. Collaborate with stakeholders to gather requirements and ensure seamless deployment across thousands of endpoints...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$96K - $145K *

Transform service delivery for complex accounts by ensuring SLAs and KPIs are met. Lead governance, performance management, and continuous improvement initiatives while building trusted relationships...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$75K - $90K *

Unlock potential by leading data analysis and storytelling efforts, ensuring insights meet client needs. Collaborate with teams to deliver actionable reports and maintain high-quality standards throug...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$80K - $95K *

Drive your career forward by cultivating client relationships and exceeding sales goals. As a key player, you'll develop marketing strategies, engage decision-makers, and provide tailored solutions to...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$155K - $241K *

Join us to shape the future of platform engineering by driving strategic initiatives, influencing organizational architecture, and enhancing developer experience across a multi-cloud environment. Your...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$225K - $250K *

Transform operations by leading a diverse team to enhance profitability and efficiency across multiple sites, while building strategic relationships with clients and driving growth initiatives in the...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$90K - $108K *

Drive successful project execution by managing customer projects from quotation to completion. Collaborate with teams and stakeholders to ensure timely delivery, quality standards, and customer satisf...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$195K - $215K *

Lead the charge in brand strategy, inspiring teams and fostering innovative solutions in a dynamic healthcare advertising environment, focused on advancing compelling communications and effective clie...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$123K - $172K *

Join our dynamic team to tackle real challenges in SaaS management, enhancing IT and Security ecosystems. Collaborate with talented professionals to build impactful software while leveraging AI for ef...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$144K - $200K *

Help us lead a national sales team focused on public safety solutions. Drive recruitment, coaching, and team performance to enhance sales effectiveness in the corrections sector, while collaborating a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$110K - $130K *

Lead the design and implementation of Manufacturing Execution Systems (MES) in the biotech and pharmaceutical sectors, ensuring effective integration and documentation while fostering strong client re...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$128K - $153K *

Join a team that's shaping the future of technology by delivering impactful software solutions. Collaborate on innovative projects, optimize data operations, and enhance user experiences while support...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Lead and enhance day-to-day accounting operations, focusing on accounts payable, receivable, and cash management. Collaborate with cross-functional teams to ensure accurate, timely transactions while...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What South Dakota jobs on Ladders pay $100,000 or more?question toggle

    Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.

  • Which South Dakota cities have high-paying jobs?question toggle

    Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.

  • Are remote jobs available to South Dakota residents?question toggle

    Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.

  • How can I find senior-level jobs in South Dakota?question toggle

    Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.

  • Does Ladders verify South Dakota job listings?question toggle

    Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.