Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.
South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.
Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.
Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.
Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.
Average Salary: $121,112
Cloud Infrastructure Architect - Remote
$120K - $160K *
Drive the design and management of cloud infrastructure, ensuring secure, scalable systems that align IT operations with business goals. Lead initiatives in automation and DevSecOps to enhance operati...
1 week ago
$96K - $101K *
Empower domestic workers by leading impactful research initiatives that inform advocacy and policy development. Drive strategic research agendas, mentor a dedicated team, and collaborate with diverse...
1 week ago
Senior Actuarial Analyst: Commercial Lines - Remote
$92K - $135K *
Grow your career with a dynamic role providing actuarial support for commercial lines, managing projects, analyzing market trends, and ensuring compliance while advancing your actuarial expertise thro...
1 week ago
Director, Enterprise CRM Delivery - Remote, United States
$150K - $180K *
Manage delivery leadership for life sciences CRM transformation programs, ensuring high-quality implementations and migrations. Collaborate with cross-functional teams to meet client expectations and...
1 week ago
Commercial Sales and Project Support
$130K - $150K *
Elevate project success by managing the lifecycle of commercial sales initiatives. Collaborate across teams to ensure accurate documentation, financial oversight, and timely invoicing, driving efficie...
1 week ago
$132K - $153K *
Join a team that's redefining care management by leading strategic initiatives in utilization and appeals processes. Drive high-quality, cost-effective care while ensuring compliance and fostering a c...
1 week ago
Customer Success Director (Oracle Focused)
$100K - $125K *
Engage with strategic Oracle customers to drive success through relationship management, implementation guidance, and value realization. Champion customer outcomes and optimize their journey with Redw...
1 week ago
$200K - $240K *
Optimize global sales strategies to drive revenue growth and market leadership. Lead the transformation of sales functions into a cohesive, customer-centric organization, ensuring alignment with long...
1 week ago
$120K - $145K *
Champion the development of clinical operations by managing a network of providers, establishing policies, and enhancing quality programs. Collaborate with leadership to ensure operational excellence...
1 week ago
STRIDES Laboratory and Diagnostics Advisor, Outbreak Preparedness and Response
$89K - $120K *
Drive initiatives to expand and strengthen laboratory systems for outbreak response and public health, ensuring alignment with national policies and international standards while providing technical l...
Reposted 1 week ago
Sr Manager, Clinical Data Management
$143K - $185K *
Unlock potential by leading clinical data management for innovative cell therapy studies. Collaborate cross-functionally to ensure data integrity and compliance while managing teams and external partn...
Reposted 1 week ago
$100K - $130K *
Lead on-site management for industrial projects, ensuring safety, efficiency, and client satisfaction. Oversee crew operations, manage resources, and drive project completion while maintaining quality...
1 week ago
Senior Medical Science Liaison - Western US
$180K - $190K *
Join a team that's dedicated to advancing precision medicine by leveraging AI to provide cutting-edge educational support and scientific expertise on cancer biomarker tests while engaging key opinion...
Reposted 1 week ago
$100K - $120K *
Join a dynamic team as you drive sales growth by cultivating client relationships and executing strategic marketing initiatives. Leverage your consultative skills to provide tailored workforce solutio...
1 week ago
$110K - $130K *
Engage with enterprise clients to drive sales growth through strategic prospecting, relationship building, and consultative solutions. Collaborate with brokers and leverage marketing strategies to exc...
1 week ago
Manager, Sales Engineering - SMB
$154K - $221K *
Lead the charge in shaping the sales engineering team for core solutions, driving revenue growth through strategic partnerships and innovative problem-solving in a dynamic environment...
1 week ago
Senior Product Owner (HYBRID - LOCAL CANDIDATES ONLY, DALLAS TX)
$110K - $130K *
Unlock potential by leading Agile delivery teams and managing product backlogs. Collaborate with stakeholders to translate business needs into actionable user stories, ensuring alignment with strategi...
1 week ago
Market Development Manager - Remote (Burbank or Pasadena)
$80K - $95K *
Transform sales performance by collaborating with distributors to enhance market presence and drive growth in the assigned territory. Leverage your expertise in DSD sales to develop local chains and e...
1 week ago
Senior Executive Talent Partner
$111K - $207K *
Empower growth by shaping executive talent strategies that drive success. Partner with senior leaders to enhance recruitment processes, develop talent pipelines, and advise on market trends, while ens...
Reposted 1 week ago
Regional Sales Manager - Remote (Boston)
$95K - $115K *
Unlock potential by leading a distributor network to drive sales growth, ensuring effective execution of business plans and fostering strong relationships within the marketplace. This role requires st...
1 week ago
Staff Software Engineer- AI Platform
$150K - $180K *
Develop and manage scalable AI infrastructure solutions, ensuring secure access to foundation models. Collaborate with cross-functional teams to enhance platform capabilities and drive AI adoption whi...
1 week ago
Configuration Management Specialist
$85K - $90K *
Elevate the future of U.S. Coast Guard acquisitions by managing configuration processes for the Waterways Commerce Cutter. Collaborate with teams to ensure compliance and accuracy in documentation and...
1 week ago
Principal Consultant - Utility Revenue Requirements Specialist
$128K - $191K *
Elevate your career by managing utility revenue requirements projects, preparing regulatory filings, and providing expert testimony. Collaborate with clients across North America while leading teams a...
1 week ago
$200K - $400K *
Empower your leadership skills to transform a dealership into a thriving 100-unit operation. Drive sales, enhance customer experiences, and cultivate a winning culture while managing all dealership de...
1 week ago
Senior Product Management Operations Manager
$120K - $145K *
Champion data-driven decision-making by establishing a unified product metrics framework. Collaborate across teams to enhance product health insights, streamline reporting, and drive strategic initiat...
1 week ago
What South Dakota jobs on Ladders pay $100,000 or more?
Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.
Which South Dakota cities have high-paying jobs?
Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.
Are remote jobs available to South Dakota residents?
Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.
How can I find senior-level jobs in South Dakota?
Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.
Does Ladders verify South Dakota job listings?
Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.