Explore South Dakota Jobs Paying $100,000 or More

Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.

Find High-Paying Opportunities Across South Dakota

South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.

Explore South Dakota’s Major Job Markets

Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.

Build Your Next Career Move

Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.

Search South Dakota Jobs on Ladders

Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $121,112

Sort By: Relevance

$135K - $160K *

Join a team that's redefining CRM platforms by architecting innovative, AI-driven solutions. This high-impact role requires visionary leadership to optimize data processing and enhance user experience...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$162K - $243K *

Lead a dynamic team in managing complex clinical research trials, ensuring project execution aligns with strategic objectives. Drive process improvements and maintain client relationships while overse...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $145K *

Optimize your skills in developing and maintaining SAS programs within a Mainframe environment. Take charge of code migration to cloud technologies and engage with stakeholders to create analytical so...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $180K *

Advance your career by owning revenue accounting and assurance in a dynamic environment. Lead the development of policies, controls, and analytics while ensuring compliance with ASC 606 and preparing...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Transportation

$150K - $180K *

Join a team that's shaping the future of AI by designing and implementing enterprise-grade solutions on Google Cloud and Azure, focusing on data migration, pipeline development, and robust cloud infra...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$95K - $115K *

Join a team that's redefining power systems engineering by leading advanced studies in T&D, enhancing software tools, and fostering collaboration across projects to drive innovation and efficiency in...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$130K - $170K *

Execute end-to-end digital onboarding of complex AI data center infrastructure, managing cross-functional teams to ensure timely delivery, stability, and optimization of high-performance systems for p...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $145K *

Innovate solutions in power systems engineering by leading consulting initiatives, enhancing client relationships, and driving strategic growth in protection and control services while ensuring high-q...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$100K - $120K *

Lead the charge in managing clinical operations for dialysis services, ensuring quality patient care, compliance, and operational efficiency across multiple facilities while fostering strong relations...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $150K *

Lead the operations of a Special Investigations Unit, managing a team of investigators to enhance fraud detection and prevention. Drive compliance, collaborate with stakeholders, and shape strategies...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Unlock insights by leading advanced data analytics for federal programs. Collaborate with cross-functional teams to ensure compliance and data integrity while mentoring junior analysts and presenting...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$100K - $120K *

Lead EHS initiatives across multiple facilities, ensuring compliance and fostering a safety culture. Drive strategic planning, conduct inspections, and collaborate with teams to enhance environmental...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Transportation

$200K - $240K *

Advance expertise in energy markets by managing complex client engagements, developing strategic recommendations, and fostering client relationships. Utilize analytical skills to drive impactful solut...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$103K - $181K *

Optimize document control processes by leading the Information Branch, ensuring accurate and accessible records management for a major industrial program while coordinating with various stakeholders a...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$88K - $154K *

Optimize document management processes for a large-scale industrial project, ensuring accurate, secure, and accessible records throughout all project phases. Collaborate with multidisciplinary teams t...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $130K *

Unlock potential by leading a global accounting team, driving process improvements, and integrating AI solutions to enhance financial operations and reporting accuracy in a dynamic SaaS environment...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$240K - $300K *

Transform patient care by providing comprehensive medical evaluations, diagnoses, and treatments. Collaborate with healthcare teams to enhance health education and ensure quality care while adhering t...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $200K *

Grow your career with a leading RIA by transitioning your client base to a sophisticated platform. Leverage a collaborative team model to deliver comprehensive wealth management solutions for high-net...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$95K - $115K *

Lead the charge in implementing the Deacom ERP platform, driving customer success through expert consultation, project management, and tailored solutions. Collaborate with clients to enhance business...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$78K - $92K *

Engage in impactful virtual counseling for patients with acute mental health conditions. Develop treatment plans, exercise clinical judgment, and collaborate with multidisciplinary teams to enhance be...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$120K - $130K *

Shape the future of mental health care by providing virtual counseling and developing treatment plans for patients with acute conditions. Collaborate with medical professionals while ensuring adherenc...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$80K - $95K *

Transform the accounting function by overseeing monthly closes, ensuring compliance, and managing tax processes. Collaborate with finance leadership to drive accurate reporting and support strategic p...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$95K - $100K *

Transform virtual learning by leading strategy and development of innovative programs. Collaborate across teams to enhance educational experiences, ensuring quality and scalability while meeting diver...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$125K - $140K *

Join a team that's dedicated to transforming supply chain solutions through innovative Oracle OTM and GTM implementations, ensuring timely delivery and optimal client satisfaction while enhancing your...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Transportation

$121K - $145K *

Strategize financial operations and enhance reporting accuracy while leading the finance team. Collaborate with senior leadership to drive financial sustainability and operational efficiency across bu...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What South Dakota jobs on Ladders pay $100,000 or more?question toggle

    Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.

  • Which South Dakota cities have high-paying jobs?question toggle

    Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.

  • Are remote jobs available to South Dakota residents?question toggle

    Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.

  • How can I find senior-level jobs in South Dakota?question toggle

    Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.

  • Does Ladders verify South Dakota job listings?question toggle

    Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.