Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.
South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.
Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.
Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.
Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.
Average Salary: $121,112
$210K - $250K *
Join a dedicated team providing comprehensive medical care and education to patients. Assess, diagnose, and treat with a focus on quality and safety, while collaborating with healthcare professionals...
1 week ago
$210K - $250K *
Transform patient care by providing comprehensive medical evaluations, diagnoses, and treatments. Collaborate with healthcare teams to enhance health education and ensure quality care while adhering t...
1 week ago
Registered Nurse (RN) | Surgery
$67K - $100K *
Optimize patient care by delivering comprehensive nursing services, developing care plans, and collaborating with healthcare teams to ensure holistic support for patients and their families. Join us i...
1 week ago
$190K - $230K *
Join a team that's driving innovation in biopharma partnerships. Leverage your expertise to identify and advance strategic opportunities, influence cross-functional decisions, and manage alliances tha...
1 week ago
Facility Coding Quality Integrity Analyst - Inpatient
$73K - $110K *
Shape the future of coding quality by overseeing audits, developing guidance, and collaborating with teams to enhance accuracy and compliance in healthcare coding practices...
1 week ago
Manager Endpoint Administrator - Remote US
$110K - $130K *
Shape the future of endpoint management by overseeing timely delivery of equipment, ensuring operational stability, and enhancing user satisfaction through effective personnel management and technical...
Reposted 1 week ago
$133K - $173K *
Shape the future of AI governance by designing frameworks and policies that ensure responsible innovation and effective risk management across the enterprise. Collaborate with cross-functional teams t...
1 week ago
Blackbaud Advisory+ Consultant - Raiser's Edge NXT
$77K - $104K *
Join a team that's dedicated to enhancing customer success with Raiser’s Edge NXT. As an Advisory+ Consultant, you'll provide expert guidance, optimize software use, and foster strong relationships to...
1 week ago
Director, Strategic Advisory Services - Theranostics, Radiopharmaceuticals, and Oncology
$156K - $235K *
Accelerate your career by leading Theranostics initiatives within a national healthcare advisory team. Collaborate with executives to enhance patient outcomes and operational performance through strat...
1 week ago
Clinical Applications Specialist, Invasive Cardiology - Houston, TX
$90K - $110K *
Champion clinical education and training by delivering expert knowledge and support to enhance user competencies and optimize patient care within a defined territory. Build strong relationships with s...
1 week ago
Sr Global Product Manager, Digital Solutions - Surgical & Procedural Care
$149K - $224K *
Lead the charge in shaping digital solutions for perioperative workflows, driving strategy and execution across cross-functional teams to enhance clinical outcomes and operational efficiency in surgic...
1 week ago
Biomedical Equipment Technician 2
$65K - $98K *
Reimagine service excellence by diagnosing and repairing complex biomedical equipment, ensuring safety and compliance, and fostering strong relationships with customers and teams to drive overall sati...
Reposted 1 week ago
HFS USCAN Operations Leader- Equipment Leasing & Loan
$126K - $189K *
Optimize operational strategies and drive excellence in leasing and loan services. Lead cross-functional teams, enhance customer satisfaction, and implement scalable systems to support strategic growt...
1 week ago
Lead Customs Specialist 1 - Customs Operations
$96K - $144K *
Lead cross-functional initiatives to enhance customs operations, ensuring compliance and optimizing performance. Drive process improvements and manage a high-performing team while leveraging data anal...
1 week ago
Financial Services Ops Manager
$81K - $122K *
Transform documentation processes by ensuring compliance, accuracy, and accessibility. Collaborate with cross-functional teams to enhance operational efficiency and support seamless integration of doc...
1 week ago
Onsite Patient Monitoring Project Manager - Georgia/Alabama
$90K - $110K *
Elevate patient care by leading project management for healthcare solutions. Drive implementation, ensure customer satisfaction, and coordinate resources while managing multiple projects in a dynamic...
1 week ago
Virtual Sales Account Manager, Ultrasound
$90K - $110K *
Drive market growth by managing a robust order funnel, collaborating with sales teams and partners to exceed revenue targets while developing strategic account plans and maintaining strong customer re...
1 week ago
Producst Sales Specialist-General Imaging - St. Louis
$90K - $110K *
Champion sales growth by developing strategic relationships and driving GI Ultrasound product sales. Leverage market insights to enhance customer engagement and achieve revenue targets while maintaini...
1 week ago
$110K - $130K *
Lead the charge in driving sales strategy for the CT product line across the Ohio Valley. Cultivate relationships, maximize revenue, and collaborate with cross-functional teams to enhance market share...
1 week ago
$116K - $155K *
Join a team that's dedicated to enhancing AI governance and risk management. You'll implement frameworks, monitor compliance, and engage with key stakeholders to ensure effective policy adoption and m...
Reposted 1 week ago
Insurance Litigation Attorney (CA License Required) – Remote
$150K - $200K *
Champion the management of insurance litigation files, providing mentorship and expertise while navigating complex legal matters and advocating for clients in a dynamic remote work environment...
Reposted 1 week ago
Principal Software Engineer - Emerging Technology & AI - Remote
$177K - $236K *
Transform the future of technology as a Principal Software Engineer, leading AI experimentation and prototyping. Collaborate across teams to design scalable solutions, mentor engineers, and drive inno...
1 week ago
$110K - $130K *
Lead the charge in transforming client challenges into innovative Salesforce solutions. Collaborate with stakeholders to design, demo, and scope projects, ensuring seamless transitions to delivery whi...
1 week ago
Senior Director, Web Strategy and Operations
$160K - $200K *
Shape the future of our web strategy by leading a cross-functional team to optimize user experience, drive demand generation, and enhance web performance. Your expertise will transform our website int...
1 week ago
Account Manager - Encaps and Inclusions
$80K - $95K *
Grow your career by driving sales and expanding market presence in the Encaps & Inclusions sector. Collaborate with cross-functional teams to deliver innovative solutions while managing key accounts a...
1 week ago
What South Dakota jobs on Ladders pay $100,000 or more?
Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.
Which South Dakota cities have high-paying jobs?
Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.
Are remote jobs available to South Dakota residents?
Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.
How can I find senior-level jobs in South Dakota?
Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.
Does Ladders verify South Dakota job listings?
Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.