Explore South Dakota Jobs Paying $100,000 or More

Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.

Find High-Paying Opportunities Across South Dakota

South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.

Explore South Dakota’s Major Job Markets

Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.

Build Your Next Career Move

Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.

Search South Dakota Jobs on Ladders

Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $121,112

Sort By: Relevance

$100K - $120K *

Empower healthcare organizations by driving sales of innovative Nurse Call solutions. Own the full sales cycle, engage with senior leaders, and leverage your expertise to navigate complex deals in a d...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Pioneer the administration and development of core business systems, focusing on ServiceNow. Collaborate with cross-functional teams to create scalable solutions that enhance operations, service, and...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $180K *

Empower your career by leading innovative GTM engineering initiatives. Drive AI workflows, automate marketing processes, and enhance productivity across teams. Collaborate with stakeholders to transfo...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Drive enterprise pipeline growth by leading integrated campaigns and demand generation strategies. Collaborate with cross-functional teams to optimize sales processes and build a high-performing marke...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $115K *

Accelerate progress at the intersection of marketing and data analytics. As a key player, you'll build reporting functions, define KPIs, and drive insights that empower teams across the organization t...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$143K - $196K *

Lead global evidence strategy and drive scientific engagement while collaborating cross-functionally to identify evidence gaps and shape priorities in clinical, R&D, and marketing teams. Make a signif...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Transform the marketing landscape by leading growth initiatives, building campaigns, and leveraging data to drive qualified pipeline. Collaborate with cross-functional teams to activate strategies and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Empower the execution of CMC strategies by collaborating across teams to enhance production, streamline operations, and drive commercial success for innovative therapeutics and diagnostics, ensuring a...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $200K *

Unlock potential by defining and guiding enterprise architecture, integrating cloud, infrastructure, and security to support business priorities. Lead modernization efforts and influence cross-functio...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$285K - $310K *

Lead the strategic execution of global clinical trials, ensuring adherence to timelines, budgets, and quality standards while fostering collaboration across teams and mentoring Clinical Operations per...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$229K - $260K *

Transform the integration landscape by architecting robust connections between NodeZero and key security platforms, ensuring reliability and observability while mentoring engineers and driving technic...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $115K *

Engineer customer reliability by providing expert technical support for IoT solutions. Collaborate with teams to resolve issues, enhance documentation, and gather feedback, ensuring a seamless custome...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$94K - $164K *

Champion cost reporting processes by ensuring data accuracy, preparing detailed reports, and analyzing financial information. Collaborate across departments to enhance reporting systems and support st...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$113K - $197K *

Lead regulatory and compliance oversight for Operations, ensuring accuracy and efficiency. Collaborate with enterprise partners to enhance operational processes, implement automation, and drive contin...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$72K - $115K *

Partner with us to design and validate predictive models that enhance business processes across various domains, leveraging data science techniques to drive insights and improve decision-making within...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$81K - $121K *

Transform retail partnerships by coaching top sellers, driving sales growth, and executing strategic plans to enhance agricultural product adoption and profitability in a dynamic, remote environment...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

$136K - $253K *

Elevate your career by leading sales strategies and fostering dealer relationships to achieve market share goals. Drive team success through effective communication and innovative sales tools while ma...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$86K - $137K *

Optimize project outcomes as you manage small to medium-sized initiatives. Collaborate across teams, navigate risks, and ensure timely delivery of quality solutions while enhancing communication and s...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$223K - $313K *

Shape the future of healthcare by leveraging your clinical expertise to review Medicare drug appeals, ensuring compliance and optimal value-based care through collaboration and analysis of complex cas...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$115K - $158K *

Drive strategies to enhance customer engagement and retention for pharmacy services. Collaborate with cross-functional teams to optimize member experiences, increase auto-refill adoption, and boost pr...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$108K - $158K *

Unlock potential by managing key accounts in the entertainment lighting sector. Drive sales growth, nurture relationships, and oversee complex projects from design to delivery, ensuring alignment and...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$126K - $176K *

Lead the charge in shaping innovative lighting solutions by managing a dynamic team, defining market strategies, and building strong relationships with key specifiers to drive business impact and enha...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$87K - $139K *

Optimize trade compliance processes by managing master data and ensuring regulatory readiness. Lead cross-functional collaboration to enhance data accuracy and streamline customs operations, driving e...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $120K *

Drive revenue growth by leading high-performing sales teams and executing strategic sales initiatives. This role combines leadership with deep expertise in performance marketing to achieve ambitious b...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Media

$80K - $140K *

Unlock potential by leading the design and governance of structured exam content. Drive standards compliance and metadata alignment across assessment systems, ensuring seamless integration and functio...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What South Dakota jobs on Ladders pay $100,000 or more?question toggle

    Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.

  • Which South Dakota cities have high-paying jobs?question toggle

    Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.

  • Are remote jobs available to South Dakota residents?question toggle

    Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.

  • How can I find senior-level jobs in South Dakota?question toggle

    Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.

  • Does Ladders verify South Dakota job listings?question toggle

    Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.