Explore South Dakota Jobs Paying $100,000 or More

Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.

Find High-Paying Opportunities Across South Dakota

South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.

Explore South Dakota’s Major Job Markets

Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.

Build Your Next Career Move

Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.

Search South Dakota Jobs on Ladders

Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $121,112

Sort By: Relevance

$110K - $130K *

Partner with us to drive innovative go-to-market strategies, enhance product positioning, and execute impactful marketing campaigns. Collaborate with cross-functional teams to analyze market trends an...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Lead the charge in advancing human factors education and research as a tenured associate professor and program chair. Drive curriculum development, foster student engagement, and contribute to a colla...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$100K - $170K *

Champion the growth of Audit Manager by driving sales in the healthcare sector. Leverage your expertise in medical billing and coding to engage revenue cycle leaders, manage the sales pipeline, and de...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Empower our channel development as you engage customers to activate solutions, becoming a key resource and expert in Absolute technology. Collaborate with sales teams to drive activations, renewals, a...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Drive technical sales success by leveraging your expertise in cloud technologies and advanced sales frameworks. Collaborate with teams to craft tailored solutions for startup and midmarket clients, en...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Transform organizational communication by building editorial standards, streamlining workflows, and enhancing writing quality across diverse teams. Collaborate with leaders to ensure clarity, purpose...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $180K *

Unlock potential by driving complex sales into Fortune 2000 accounts, engaging with key stakeholders in compliance and technology. Shape the future of AI in enterprise solutions while achieving ambiti...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$140K - $170K *

Drive growth by managing key customer relationships in the Southeast and West Coast. Lead strategic initiatives, pricing, and account development while collaborating with dedicated coordinators to enh...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$128K - $160K *

Manage the integration and presentation of financial data within a leading market intelligence platform. Collaborate with cross-functional teams to enhance search and agentic capabilities, ensuring da...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$210K - $256K *

Accelerate progress at a leading consulting firm by managing a large-scale data transformation program. Oversee governance, stakeholder alignment, and change management across multiple workstreams to...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Information Technology

$66K - $102K *

Elevate your career by joining our consulting team to design and implement SAP PP/QM solutions, driving value for clients through innovative strategies and expert knowledge transfer in a dynamic, glob...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$73K - $102K *

Bring your expertise to enhance ERP solutions by collaborating with stakeholders, customizing modules, and ensuring seamless integration while maintaining compliance and performance standards...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$140K - $180K *

Shape the future of clinical quality assurance by overseeing trials, ensuring compliance with GCP and ICH standards, and driving operational excellence across clinical activities within a cross-functi...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$83K - $93K *

Join a team that's dedicated to servicing and repairing CNC machine tools. Perform complex diagnostics and repairs, ensuring operational excellence through customer interaction, advanced troubleshooti...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$275K - $405K *

Transform developer engagement by leading a global team that inspires and equips developers. Drive strategic initiatives, foster community, and enhance Twilio's presence in the developer ecosystem thr...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Transportation

$114K - $167K *

Lead the charge in optimizing ERP solutions by analyzing complex business processes, designing customizations, and implementing integration workflows to enhance performance and compliance across vario...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$106K - $167K *

Join a team that's redefining ERP solutions by analyzing complex business processes, developing custom architectures, and leading data migrations to optimize performance and compliance across diverse...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$130K - $155K *

Transform your career by designing and scaling a cutting-edge cloud-native data platform. Collaborate with cross-functional teams to deliver robust data services and optimize data pipelines in a dynam...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$107K - $144K *

Lead and execute comprehensive quality assurance for Workday implementations, ensuring alignment with business needs and high-quality outcomes. Oversee testing strategies, manage defect lifecycles, an...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$80K - $105K *

Engage in frontline cyber investigations to safeguard AI systems from malicious threats. Analyze flagged telemetry, evaluate cyber prompts, and enhance automated safety classifiers while collaborating...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Business Services

$104K - $145K *

Unlock your potential as an Electronics Engineer, providing expertise in communication and SCADA systems. Collaborate on system design, enhance performance, and ensure operational excellence across th...

Reposted 6 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$104K - $145K *

Unlock potential by providing engineering expertise to enhance communication and SCADA systems. Collaborate on system design, troubleshoot issues, and ensure operational efficiency across the region's...

Reposted 6 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$78K - $120K *

Drive the optimization of our Salesforce platform, ensuring user support and seamless configuration management. Collaborate to implement solutions and enhance security protocols while staying current...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$125K - $150K *

Bring your expertise to drive revenue growth in healthcare through consultative sales and strategic partnerships. Own the full sales cycle, collaborate cross-functionally, and mentor future hires in a...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$140K - $165K *

Empower clients by leveraging technical expertise to demonstrate product value, cultivate relationships, and drive sales success through effective communication and strategic engagement with stakehold...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What South Dakota jobs on Ladders pay $100,000 or more?question toggle

    Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.

  • Which South Dakota cities have high-paying jobs?question toggle

    Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.

  • Are remote jobs available to South Dakota residents?question toggle

    Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.

  • How can I find senior-level jobs in South Dakota?question toggle

    Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.

  • Does Ladders verify South Dakota job listings?question toggle

    Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.