Explore South Dakota Jobs Paying $100,000 or More

Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.

Find High-Paying Opportunities Across South Dakota

South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.

Explore South Dakota’s Major Job Markets

Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.

Build Your Next Career Move

Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.

Search South Dakota Jobs on Ladders

Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $121,112

Sort By: Relevance

$123K - $169K *

Unlock potential by leading reliability improvement programs across a global network of manufacturing sites and distribution centers. Drive hands-on engineering initiatives, optimize maintenance strat...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$210K - $230K *

Lead the charge in developing enterprise pricing strategies that optimize profitability and drive growth across diverse service sectors, ensuring alignment with market conditions and client needs whil...

RemoteRemote

4 days ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$110K - $130K *

Elevate your career by developing and optimizing machine learning models, collaborating with cross-functional teams to drive data-driven solutions and enhance predictive analytics in a dynamic, Agile...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $199K *

Develop and maintain scalable data pipelines, leveraging Snowflake and cloud tools to enhance data quality and accessibility. Mentor a growing team while driving best practices in data engineering and...

RemoteRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $145K *

Lead the charge in web growth design, optimizing top-of-funnel experiences to enhance customer engagement and conversion. Collaborate with cross-functional teams to create compelling, high-quality web...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$80K - $95K *

Take ownership of client-centric commerce media strategies, optimizing campaigns across platforms like Amazon and Walmart. Leverage data insights to drive growth and ensure client satisfaction while c...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Media

$110K - $130K *

Unlock potential by leading the full sales cycle, building executive relationships, and driving business transformation across industries. Collaborate with teams to innovate sales processes and ensure...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$315K - $370K *

Join a team that's redefining offensive security by leading engineering efforts to transform research into scalable, customer-facing products. Drive strategy, execution, and innovation across multiple...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$90K - $110K *

Unlock potential by leading compliance initiatives and advising leadership on regulatory strategies. This role ensures adherence to laws, mentors staff, and collaborates with stakeholders to mitigate...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$106K - $197K *

Elevate your career by managing complex revenue accounting activities, leading process improvements, and collaborating across teams to enhance scalability and efficiency in a dynamic environment focus...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$85K - $100K *

Unlock potential by leading engineering programs at a dynamic healthcare facility. Collaborate with diverse teams to enhance operations, ensure compliance, and drive strategic initiatives that support...

4 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$175K - $237K *

Lead the charge in digital manufacturing innovation, transforming operational needs into practical solutions. Collaborate globally to enhance data, AI, and automation capabilities, ensuring safe and e...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Transform aircraft maintenance processes as a B-1 Flight Systems SME, enhancing lifecycle management and logistics support. Collaborate with engineering and logistics teams to ensure mission success a...

4 days ago

  •   15+ years exp.  •   Aerospace & Defense

$140K - $195K *

Engage in strategic business development, overseeing global projects and teams. Drive long-term planning, policy formation, and customer negotiations while fostering collaboration with senior manageme...

RemoteRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$108K - $180K *

Join us in leading product strategy and execution for a diverse portfolio, enhancing Provider Contracting and Credentialing. Collaborate with cross-functional teams to drive innovation, improve custom...

RemoteRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$153K - $290K *

Transform drug discovery by leading a dynamic team in medicinal chemistry, driving innovative small-molecule candidates from concept to IND-ready status while fostering collaboration across a global n...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$177K - $338K *

Champion DMPK project leadership by ensuring high-quality data delivery and supporting drug candidate progression through innovative modeling and cross-functional collaboration in a dynamic biotech en...

RemoteRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$117K - $189K *

Pioneer global Orexin development programs by driving project management efforts. Partner with the Global Team Leader to oversee cross-functional teams, manage critical activities, and ensure project...

RemoteRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Unlock potential by leading the digital banking strategy and execution. Collaborate across teams to enhance customer experiences, drive operational efficiency, and support business growth through inno...

Reposted 4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$75K - $95K *

Unlock potential by managing Genesys Cloud configurations and ensuring system integrity. Collaborate with teams to implement changes, troubleshoot issues, and maintain documentation for optimal contac...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Transportation

$240K - $290K *

Elevate your career by leading a dynamic engineering team focused on production and infrastructure. Drive performance, foster collaboration, and deliver innovative solutions while managing diverse tec...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$154K - $242K *

Champion operational excellence by leading global tax provisions and compliance. Collaborate with cross-functional teams to enhance processes, mentor talent, and drive strategic tax initiatives while...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$82K - $150K *

Accelerate growth by driving new customer acquisition and expanding market share within the dental implant community. Leverage a hunter mentality to convert competitive accounts and position value-ori...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Healthcare

$140K - $190K *

Lead the charge in driving sales growth within the Pulmonary therapeutic area by building strong relationships with healthcare professionals and implementing strategic initiatives to enhance product u...

RemoteRemote

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$130K - $160K *

Transform data operations by leading our Snowflake platform migration, ensuring security, reliability, and cost efficiency while collaborating across teams to standardize practices and enhance data ma...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

Frequently Asked Questions (FAQ)

  • What South Dakota jobs on Ladders pay $100,000 or more?question toggle

    Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.

  • Which South Dakota cities have high-paying jobs?question toggle

    Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.

  • Are remote jobs available to South Dakota residents?question toggle

    Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.

  • How can I find senior-level jobs in South Dakota?question toggle

    Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.

  • Does Ladders verify South Dakota job listings?question toggle

    Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.