Explore South Dakota Jobs Paying $100,000 or More

Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.

Find High-Paying Opportunities Across South Dakota

South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.

Explore South Dakota’s Major Job Markets

Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.

Build Your Next Career Move

Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.

Search South Dakota Jobs on Ladders

Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $121,112

Sort By: Relevance

$222K - $278K *

Join a dynamic team to drive enterprise sales, transforming industries through innovative technology. Engage with C-level executives, manage complex deals, and foster lasting relationships to enhance...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $300K *

Lead complex analytical initiatives by developing data solutions and dashboards that drive business insights. Collaborate with stakeholders to translate requirements into scalable analytical framework...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$190K - $220K *

Champion innovation and execution as you lead product management across diverse e-commerce channels. Drive strategic roadmaps, manage global teams, and deliver cutting-edge solutions that enhance cust...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Enterprise Technology

$115K - $150K *

Innovate at the forefront of database management, ensuring performance, reliability, and security in a high-volume SQL Server environment. Lead incident response and engineering solutions to enhance o...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$156K - $227K *

Elevate executive compensation strategies by designing and leading Total Rewards programs that align with organizational goals, while collaborating with key stakeholders to ensure compliance and effec...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $160K *

Unlock potential by leading complex cyber investigations, mentoring junior analysts, and analyzing sophisticated threats to safeguard AI systems from misuse. Drive impactful decisions and enhance safe...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Business Services

$144K - $211K *

Drive engineering excellence by leading a high-performing team in implementing and scaling industrial control systems. Collaborate across functions to ensure reliable, maintainable solutions that supp...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$120K - $160K *

Engineer the future of critical facility commissioning by leading project teams, managing schedules, and ensuring compliance with design and safety standards. Drive successful project execution throug...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Technical Services

$160K - $229K *

Lead the design and development of AI-driven solutions within SAP S/4HANA, integrating advanced AI technologies to drive business transformation and innovation across enterprise environments. Mentor t...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$123K - $135K *

Engage with existing customer accounts to drive renewal retention and expansion revenue. This growth-focused role emphasizes consultative upselling and cross-selling, ensuring customer satisfaction wh...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $141K *

Join a team that's dedicated to providing expert bioinformatics support, bridging customer needs with innovative NGS solutions. You'll play a key role in pre- and post-sales activities, ensuring custo...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$180K - $200K *

Lead water infrastructure strategies, ensuring efficient design and compliance across data center projects. Collaborate with teams to secure agreements and manage risks, enhancing sustainability and c...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Empower our engineering teams by leading technical recruitment efforts. Dive deep into candidate sourcing, build strong pipelines, and enhance the hiring process while ensuring a positive candidate ex...

RemoteRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$130K - $160K *

Transform program execution by coordinating large-scale data center initiatives, ensuring alignment across stakeholders, managing risks, and driving milestones to successful completion while fostering...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Business Services

$90K - $130K *

Join a team that's driving large-scale infrastructure projects. As a Project Manager, you'll lead initiatives from kickoff to closeout, ensuring alignment with program objectives and stakeholder expec...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Business Services

$90K - $117K *

Elevate your career by leading SDTM programming activities, ensuring quality deliverables, and collaborating cross-functionally to optimize clinical data transformation in a dynamic environment...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$128K - $250K *

Innovate enterprise sales by leading the strategy for large deal pursuits, engaging C-suite clients, and delivering transformative solutions in retail and logistics sectors...

United StatesRemote

Reposted 4 days ago

  •   11 - 15 years exp.  •   Information Technology

$125K - $145K *

Lead campaign strategy and execution for oncology pharma marketing, driving performance optimization and cross-functional collaboration. Own end-to-end campaign management, ensuring alignment with bus...

United StatesRemote

Reposted 4 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$170K - $220K *

Lead the charge in providing comprehensive legal support for the CHVAC segment, collaborating with global teams to ensure compliance and address complex legal matters while driving strategic initiativ...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$135K - $160K *

Lead the charge in quality and validation readiness for complex programs, uniting Engineering, Product, and Customer Success teams. Utilize AI and automation to streamline processes, enhance delivery...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $100K *

Join a team that's driving growth by acquiring new customers and enhancing revenue through innovative solutions. Manage the full sales cycle while collaborating with cross-functional teams to ensure e...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$91K *

Champion cross-functional programs that drive strategic outcomes, ensuring alignment with organizational priorities. Lead complex initiatives, manage risks, and foster stakeholder engagement to delive...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Media

$207K - $346K *

Lead the charge in evidence-based medical case reviews to ensure high-quality patient care while collaborating with a network of over 500 physician colleagues in a fully remote environment...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Transform the future of utility-scale solar projects by leading electrical operations, ensuring quality installations, and fostering strong team collaboration while managing contractor activities and...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$91K - $115K *

Transform the candidate experience by sourcing top talent for sales and corporate roles. Collaborate with recruiters and hiring managers to build pipelines, utilizing advanced sourcing techniques and...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What South Dakota jobs on Ladders pay $100,000 or more?question toggle

    Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.

  • Which South Dakota cities have high-paying jobs?question toggle

    Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.

  • Are remote jobs available to South Dakota residents?question toggle

    Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.

  • How can I find senior-level jobs in South Dakota?question toggle

    Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.

  • Does Ladders verify South Dakota job listings?question toggle

    Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.