Explore South Dakota Jobs Paying $100,000 or More

Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.

Find High-Paying Opportunities Across South Dakota

South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.

Explore South Dakota’s Major Job Markets

Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.

Build Your Next Career Move

Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.

Search South Dakota Jobs on Ladders

Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$100K - $108K *

Join a dynamic team to provide essential data management and help desk support for public health initiatives, ensuring effective communication and technical assistance for healthcare facilities and us...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$100K - $108K *

Unlock potential by providing essential data management and help desk support for public health initiatives, ensuring efficient operations and user assistance in a dynamic healthcare environment...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$90K - $95K *

Accelerate progress at the forefront of multimedia design, creating innovative 3D assets and motion graphics. Collaborate with cross-functional teams to deliver engaging eLearning content while mentor...

RemoteRemote

4 days ago

  •   11 - 15 years exp.  •   Aerospace & Defense

$125K - $150K *

Empower a robust enterprise network-security infrastructure by leading initiatives in design, operation, and troubleshooting of advanced firewall systems. Collaborate with cross-functional teams to en...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Information Technology

$143K - $214K *

Oversee and enhance security measures across network, compliance, and access management. Collaborate with teams to design and implement resilient infrastructure while leading a high-performing securit...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Information Technology

$110K - $130K *

Advance your career by leading substation projects, managing design and execution for diverse clients. Collaborate with teams to ensure quality, safety, and efficiency while driving operational improv...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$75K - $96K *

Unlock your potential as a key player in our overnight security operations, enhancing AI-driven incident response and automation. Your expertise will shape how we detect and respond to threats, ensuri...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$146K - $234K *

Transform complex challenges into innovative solutions by leveraging expertise in RF communications, machine learning, and data analytics to enhance cybersecurity and network research for government a...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Aerospace & Defense

$66K - $106K *

Contribute to data-driven decision-making by designing and optimizing analytic solutions. Leverage your expertise in SQL and Tableau to transform raw data into actionable insights for mission-critical...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$104K - $166K *

Transform the security landscape by providing expert information assurance support for cloud-hosted systems. Collaborate with Agile teams to enhance security protocols and ensure compliance with feder...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$93K - $116K *

Empower integrated marketing campaigns with a focus on account-based marketing. Collaborate with Sales to prioritize accounts, align messaging, and drive pipeline growth while managing multi-channel c...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$77K - $97K *

Explore and enhance our Salesforce platform, driving scalable solutions across Revenue Operations. Collaborate with cross-functional teams to optimize workflows and ensure seamless integrations, while...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$113K - $133K *

Shape global health initiatives by managing HIV programs, coordinating with stakeholders, and ensuring timely reporting. This role offers hands-on experience in public health, ideal for detail-oriente...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Business Services

$81K - $95K *

Join a dynamic team to provide vital administrative and operational support, enhancing global health security initiatives. Collaborate across offices to streamline processes, manage communications, an...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Business Services

$174K - $217K *

Drive strategic leadership in industry partnerships and payor strategy, enhancing market access and competitive positioning. Lead a high-performing team to execute a multiyear plan that fosters sustai...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Healthcare

$90K - $111K *

Optimize customer interactions by leading design and prototyping efforts. Collaborate with stakeholders to enhance experiences, drive strategic planning, and implement innovative solutions that align...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$124K - $155K *

Champion data-driven insights as you lead a multidisciplinary analytics team, driving client performance and strategic recommendations to enhance business growth and market competitiveness...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$101K - $204K *

Lead and innovate as a Staff Software Engineer, guiding agile teams to design, develop, and maintain complex software systems while mentoring junior engineers and ensuring high-quality delivery of pro...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$92K - $138K *

Empower your career by transforming demand into actionable workforce strategies. Lead capacity planning and vendor performance in a dynamic remote environment, ensuring optimal resource allocation and...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$69K - $103K *

Join a team that's dedicated to ensuring seamless member scheduling and access. As a Production Support Analyst, you'll monitor platform health, resolve data issues, and collaborate with cross-functio...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Unlock your potential as you manage high-severity casualty claims, navigating complex liability issues and litigation. Collaborate with teams to drive innovative solutions while ensuring exceptional s...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$93K - $158K *

Shape the future of data visualization by leading the design and delivery of impactful dashboards and analytics. Collaborate with stakeholders to transform complex data into actionable insights using...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Business Services

$125K - $145K *

Champion cross-functional collaboration and project management to enhance USPS operations. Drive strategic solutions, stakeholder engagement, and process improvements while leveraging Agile methodolog...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Business Services

$95K - $115K *

Champion partner-led demand generation by developing and executing scalable marketing strategies. Collaborate with sales and marketing teams to drive pipeline growth and optimize performance across ke...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Shape the future of enterprise software by leading product strategy, design, and delivery for impactful applications supporting federal missions. Collaborate across multifunctional teams to ensure sec...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What South Dakota jobs on Ladders pay $100,000 or more?question toggle

    Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.

  • Which South Dakota cities have high-paying jobs?question toggle

    Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.

  • Are remote jobs available to South Dakota residents?question toggle

    Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.

  • How can I find senior-level jobs in South Dakota?question toggle

    Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.

  • Does Ladders verify South Dakota job listings?question toggle

    Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.