Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$75K - $94K *

Optimize talent acquisition by partnering with clinical leadership to recruit licensed mental health therapists. Drive the full-cycle recruiting process, ensuring an exceptional candidate experience w...

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  •   Less than 5 years exp.  •   Healthcare

$160K - $192K *

Join us to drive commercial performance by engaging healthcare providers, building relationships, and supporting product launches. Collaborate with cross-functional teams to ensure patient access to i...

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  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Transform go-to-market strategies by executing industry-focused marketing initiatives, driving collaboration across teams to enhance growth initiatives with tailored messaging and customer insights, f...

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  •   Less than 5 years exp.  •   Energy & Utilities

$148K - $263K *

Architect high-performance OneStream solutions by translating complex requirements into scalable designs. Lead a team of consultants, ensuring technical quality and optimizing integrations while excee...

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  •   8 - 10 years exp.  •   Information Technology

$80K - $118K *

Unlock potential by driving growth and retention of strategic accounts while identifying new business opportunities. Collaborate with teams to enhance customer productivity and operational performance...

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  •   Less than 5 years exp.  •   Business Services

$102K - $140K *

Shape the future of customer success by leading implementation strategies, fostering cross-functional partnerships, and driving scalable processes for new customer rollouts in a dynamic B2B SaaS envir...

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  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Unlock potential by leading a high-performing broker network to optimize revenue growth and enhance conversion success through strategic data analytics and collaboration...

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  •   5 - 7 years exp.  •   Real Estate & Construction

$126K - $150K *

Champion growth strategies for net-new business, driving critical sales across cyber threat intelligence. Influence Fortune 1000 leaders in high-stakes environments while navigating complex sales cycl...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Engage with cross-functional teams to drive clinical trial success across regions. Leverage your expertise in project management and mentoring to ensure compliance, quality, and timely execution of st...

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  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$130K - $160K *

Unlock your potential as a Senior Full Stack Software Engineer, leading impactful projects and shaping technology solutions. Collaborate across web applications, backend services, and cloud infrastruc...

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  •   5 - 7 years exp.  •   Finance & Insurance

$90K - $120K *

Drive revenue growth by optimizing systems and processes across Marketing, Sales, and Customer Success. Leverage data to enhance operational efficiency and establish HubSpot as a reliable source of tr...

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  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Lead the charge in AI innovation within our Insurance portfolio, overseeing the full lifecycle of solutions from ideation to production. Shape strategy, manage multidisciplinary teams, and build new c...

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  •   8 - 10 years exp.  •   Information Technology

$169K - $255K *

Shape the future of personalized consumer products by driving strategic partnerships and revenue growth. Lead business development efforts, cultivate relationships, and expand market reach to position...

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  •   11 - 15 years exp.  •   Retail & Consumer Goods

$75K - $90K *

Optimize lease administration processes by conducting detailed reconciliations and audits for large clients, ensuring compliance with lease terms while delivering accurate financial reporting and fost...

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  •   Less than 5 years exp.  •   Real Estate & Construction

$79K - $139K *

Join a team that's dedicated to driving excellence in clinical trial contracts. As a Senior Site Contracts Manager, you'll negotiate and manage site budgets and agreements, collaborating with key stak...

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  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Advance your career by leading medical writing projects in a regulatory environment. Collaborate with cross-functional teams to produce high-quality documents, ensuring compliance with industry standa...

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  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Partner with us to drive transformative healthcare solutions by managing key accounts, fostering relationships, and ensuring measurable outcomes. Your expertise will enhance provider partnerships and...

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  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Drive Beam's growth by securing partnerships and expanding market presence. Lead the sales cycle for Beam Notes, engaging key sectors and refining strategies to enhance product-market fit in the US. Y...

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  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $200K *

Transform security architecture by defining standards, leading reviews, and managing risks. Collaborate with teams to ensure secure, efficient integration of applications and AI, while maintaining cle...

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  •   8 - 10 years exp.  •   Information Technology

$76K - $93K *

Unlock potential by leading prospect research and development efforts to enhance fundraising strategies. Collaborate across teams to optimize pipelines, improve data practices, and drive revenue growt...

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  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Reimagine payroll processes by building and managing US and international payroll systems. Own compliance, tax filings, and month-end close while collaborating with teams to ensure accuracy and effici...

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  •   5 - 7 years exp.  •   Information Technology

$81K - $130K *

Lead the charge in delivering high-impact market research solutions, managing multiple projects, and fostering client relationships. Coach and elevate team standards while utilizing innovative methodo...

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  •   5 - 7 years exp.  •   Information Technology

$90K - $110K *

Unlock your potential by designing advanced PCB layouts and collaborating on innovative RF designs. This remote role requires expertise in Altium and a strong understanding of PCB standards to drive q...

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  •   5 - 7 years exp.  •   Information Technology

$160K - $185K *

Lead the charge in designing Azure platforms for healthcare data products, ensuring resilience, security, and cost management while mentoring engineers and shaping architectural standards in a fully r...

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  •   8 - 10 years exp.  •   Healthcare

$150K - $175K *

Lead the charge in transforming financial operations while ensuring compliance and accuracy. Collaborate with cross-functional teams to enhance processes, manage audits, and drive strategic initiative...

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  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.