Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.
South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.
Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.
Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.
Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.
Average Salary: $119,100
Director Global Safety- Global Periodic Aggregate Safety Reports
$191K - $258K *
Shape the future of global safety by leading the development and submission of periodic aggregate safety reports. Drive compliance and collaboration across teams while managing a diverse global team t...
4 days ago
$85K - $100K *
Deliver advanced field service support for Promega instrumentation, ensuring installation, training, and repairs meet customer service standards. Collaborate with teams to enhance service documentatio...
4 days ago
Senior Director of Design, Search & Feeds
$317K - $443K *
Engage with cross-functional teams to shape the design vision for search and feeds, leading a talented design group to enhance user discovery and community connections while driving growth and retenti...
4 days ago
$80K - $95K *
Join a team that's dedicated to enhancing automation solutions through troubleshooting, programming, and customer collaboration. Leverage your skills to improve machinery performance and ensure seamle...
Reposted 4 days ago
National Account Director, Community Oncology
$245K - $290K *
Champion strategic relationships in community oncology to enhance market access for innovative therapies. Drive account strategies, negotiate contracts, and collaborate cross-functionally to ensure op...
4 days ago
Sales Solutions Engineer - 1079
$80K - $95K *
Shape the future of client solutions by leading technical discovery and crafting innovative data-driven strategies. Collaborate with sales teams to drive success and ensure seamless implementation of...
4 days ago
AI Deployment Engineer/Manager
$80K - $95K *
Champion the deployment of cutting-edge AI systems in diverse environments. Collaborate with teams to ensure seamless installation and operation of hardware and software, while providing exceptional c...
4 days ago
Supervisory Pharmacist (Clinical)
$100K - $120K *
Elevate pharmacy operations by leading strategic initiatives, ensuring compliance, and managing a skilled team to deliver exceptional patient care and medication management services in a dynamic healt...
Reposted 4 days ago
Supervisory Pharmacist (Clinical)
$100K - $120K *
Join a dynamic team as you oversee pharmacy operations, ensuring compliance and excellence in clinical care. Lead a diverse staff, manage performance, and collaborate effectively for optimal patient o...
Reposted 4 days ago
Senior Director, Alliance Management
$242K - $290K *
Empower strategic partnerships by managing alliances, driving collaboration, and ensuring alignment with organizational goals. Leverage your expertise to foster trust and deliver impactful outcomes in...
4 days ago
Professional Services Engineer - Remote
$110K - $160K *
Optimize customer networks while delivering integrated networking and cybersecurity solutions. Collaborate globally, enhance performance, and ensure satisfaction as you tackle complex challenges in an...
Reposted 4 days ago
Strategic Advertising Account Executive
$138K - $202K *
Drive impactful strategies in enterprise advertising sales, partnering with complex clients to leverage AI and predictive insights for revenue growth. Influence outcomes in a fast-paced environment wh...
Reposted 4 days ago
$100K - $120K *
Lead the monthly close and day-to-day accounting operations, ensuring accuracy and efficiency as the business scales. Collaborate with cross-functional teams to enhance processes and implement automat...
4 days ago
Senior Strategist, Paid Search (DTC)
$85K - $106K *
Empower clients by leading innovative paid search strategies across diverse categories. Collaborate with cross-functional teams to drive performance, optimize campaigns, and connect search tactics to...
4 days ago
$80K - $95K *
Lead the implementation of safety programs across multiple wind and solar project sites, ensuring compliance and promoting a safe work environment for all team members and contractors. Collaborate wit...
Reposted 4 days ago
Territory Manager - Glaucoma - Central
$90K - $140K *
Unlock potential by driving growth and adoption of innovative surgical glaucoma technology. Collaborate with surgeons and staff to deliver exceptional support and education, while building sustainable...
Reposted 4 days ago
21GRAMS- Creative Director, Copy
$200K - $220K *
Drive impactful healthcare advertising by leading creative teams, overseeing brand strategies, and ensuring high-quality copy and art execution. Collaborate across departments to foster innovation and...
4 days ago
Commercial Casualty Supervisor, Complex Claims - Remote
$110K - $147K *
Transform complex claims management by supervising 1st and 3rd party auto and commercial injury claims. Lead a remote team, ensuring compliance and operational excellence while fostering strong relati...
4 days ago
VP OF SALES - EAST COAST - HEALTHCARE
$160K - $200K *
Empower your career by leading a high-performing sales team to drive profitable growth in the healthcare sector. Develop and execute strategic sales initiatives, foster client relationships, and ensur...
Reposted 4 days ago
Senior Account Executive II, Federal DOW/Army/Navy/Air Force/Pentagon
$140K - $175K *
Transform your career by engaging with federal clients, driving enterprise solutions, and building lasting relationships in a dynamic SaaS environment. Leverage your technical expertise to exceed sale...
4 days ago
$180K - $220K *
Optimize revenue and profitability as you lead commercial finance, drive pricing strategies, and negotiate pivotal agreements with stakeholders, playing a vital role in shaping financial success acros...
Reposted 4 days ago
Senior Engineering Manager - GTM
$239K - $298K *
Discover a pivotal role in shaping the future of our engineering function. Lead a small team to enhance our GTM engine, integrating product and marketing efforts while driving innovation in technology...
4 days ago
Division Vice President IT and Digital Transformation- Aerospace & Defense Division
$225K - $250K *
Lead the charge in pioneering technology strategies that enhance operational excellence and drive innovation across multiple business units. Partner with leaders to implement advanced solutions in AI...
Reposted 4 days ago
$110K - $145K *
Partner with us to drive sales growth and elevate client relationships. Utilize tailored product demos and consultative techniques to enhance customer satisfaction and revenue, while leveraging your e...
Reposted 4 days ago
$125K - $150K *
Join a team that's building the Keycard Agent SDK to empower developers by enhancing trust, governance, and telemetry for AI agents. Collaborate on innovative solutions across multiple languages and f...
Reposted 4 days ago
What South Dakota jobs on Ladders pay $100,000 or more?
Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.
Which South Dakota cities have high-paying jobs?
Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.
Are remote jobs available to South Dakota residents?
Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.
How can I find senior-level jobs in South Dakota?
Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.
Does Ladders verify South Dakota job listings?
Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.