Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.
South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.
Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.
Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.
Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.
Average Salary: $119,100
$150K - $160K *
Develop and execute strategies for deployment options across cloud and self-hosted setups, ensuring compliance and security. Collaborate with cross-functional teams to enhance product offerings and dr...
3 days ago
$84K - $124K *
Transform software solutions by designing, developing, and enhancing applications in an agile environment. Collaborate with teams to deliver high-quality, scalable systems while ensuring transparency...
3 days ago
$120K - $130K *
Manage strategic accounts within the Life Sciences sector, driving growth by cultivating customer relationships and identifying new business opportunities. Leverage industry knowledge to ensure alignm...
Reposted 3 days ago
Regional Sales Manager - Southeastern US
$100K - $130K *
Take ownership of sales within a key territory, identifying opportunities and nurturing relationships with clients to drive business growth and exceed sales goals through strategic engagement and effe...
Reposted 3 days ago
$150K - $180K *
Drive exceptional support experiences globally, leading a high-performing team to enhance operational efficiency and scale offerings as our customer base and product suite expand...
Reposted 3 days ago
Digital Sales Director - California
$90K - $130K *
Drive revenue growth by developing strategic sales plans and building client relationships in the dynamic Connected TV advertising landscape. Leverage industry knowledge to identify opportunities and...
3 days ago
Sr. Account Manager - Renewals/Expansion
$140K - $175K *
Join a dynamic team as you drive renewals and expansion for managed sales customers. Leverage executive relationships and strategic planning to enhance account growth while collaborating with cross-fu...
3 days ago
MIS Product Specialist - Spinning Disk Confocal Systems - West
$96K - $120K *
Champion the growth of SPINNING Systems by leveraging technical expertise, driving sales initiatives, and collaborating across teams to enhance customer engagement and market presence in the life scie...
Reposted 3 days ago
MIS Product Specialist - Spinning Disk Confocal Systems - East
$96K - $120K *
Pioneer growth and market penetration for advanced SPINNING Systems. Leverage technical expertise to support sales, engage customers, and collaborate cross-functionally, driving innovative solutions a...
Reposted 3 days ago
$150K - $240K *
Develop innovative PCB layouts and improve product designs by collaborating with cross-functional teams. Ensure high quality and compliance throughout the engineering and manufacturing process, while...
Reposted 3 days ago
$70K - $94K *
Elevate your career by leading innovative paid media initiatives, optimizing campaigns, and exploring emerging channels to enhance enrollment strategies. Collaborate cross-functionally to drive perfor...
3 days ago
Territory Manager - Remote (MN/ND/SD)
$88K - $105K *
Join a team that accelerates growth in the Electric Utility sector by building robust relationships, driving sales strategies, and expanding market presence across multiple states. Ideal for motivated...
Reposted 3 days ago
$162K - $185K *
Drive strategic product development to meet growth goals, prioritizing user impact and results while collaborating with cross-functional teams to deliver innovative solutions that resonate with both B...
Reposted 3 days ago
$110K - $130K *
Transform the cybersecurity landscape by driving revenue growth and building strong customer relationships in the mid-market segment. Leverage consultative selling and AI-driven solutions to engage te...
3 days ago
Medical Review Nurse II - SNF/MDS Auditor
$90K - $105K *
Tackle medical claims audits in a dynamic remote environment, collaborating with a skilled team to ensure compliance and accuracy in Skilled Nursing Facility reviews while enhancing audit processes an...
3 days ago
Territory Sales Representative, Implants MIS
$82K - $150K *
Drive growth by aggressively prospecting and converting new dental implant accounts. Leverage a hunter mentality to expand market share, build relationships, and position value-oriented solutions with...
Reposted 3 days ago
Associate Medical Director- Rare Neuro
$175K - $200K *
Drive strategic medical initiatives in Rare Neurology, collaborating with cross-functional teams to enhance patient outcomes. Leverage your expertise to shape launch strategies and foster relationship...
Reposted 3 days ago
VP, Global Sales, Inventory & Operations Planning
$175K - $210K *
Lead the global SIOP process, ensuring synchronization across Sales, Marketing, and Supply Chain functions to optimize inventory and enhance operational efficiency for $1.2B in annual sales. Drive str...
Reposted 3 days ago
$140K - $175K *
Shape technical innovation by leading cross-team efforts in system architecture and development. Drive scalable improvements, mentor peers, and influence business outcomes while ensuring long-term mai...
3 days ago
$300K - $500K *
Champion innovation by architecting and developing high-performance, real-time trading web apps. Leverage your expertise to enhance user experience and drive product evolution in a dynamic, collaborat...
3 days ago
$64K - $102K *
Elevate network performance by deploying and optimizing voice solutions, ensuring 99.999% uptime. Collaborate on network planning and security, while providing expert support and documentation for com...
Reposted 3 days ago
$60K - $120K *
Empower growth by engaging existing customers, identifying upgrade opportunities, and managing the full sales cycle. Build trust with small business owners while driving revenue through effective outr...
3 days ago
Staff, Product Manager - Identity
$155K - $228K *
Join a team that's shaping the future of identity products, delivering secure, developer-first experiences. Collaborate with leadership to build innovative solutions that empower customers and enhance...
3 days ago
Account Executive - North America New Logo
$140K - $220K *
Join a dynamic team focused on driving new business growth through strategic sales initiatives. Engage with key decision-makers, execute impactful presentations, and leverage multi-channel outreach to...
3 days ago
Regulatory Affairs Director (Remote - United States)
$211K - $290K *
Champion global regulatory strategies to drive product approvals and market access for innovative dental solutions. Collaborate with cross-functional teams to navigate complex regulatory landscapes an...
3 days ago
What South Dakota jobs on Ladders pay $100,000 or more?
Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.
Which South Dakota cities have high-paying jobs?
Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.
Are remote jobs available to South Dakota residents?
Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.
How can I find senior-level jobs in South Dakota?
Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.
Does Ladders verify South Dakota job listings?
Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.