Explore South Dakota Jobs Paying $100,000 or More

Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.

Find High-Paying Opportunities Across South Dakota

South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.

Explore South Dakota’s Major Job Markets

Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.

Build Your Next Career Move

Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.

Search South Dakota Jobs on Ladders

Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$350K *

Champion innovative AI solutions by driving strategic partnerships with complex accounts. Collaborate with sales teams to maximize value and ensure successful adoption of AI products, impacting indust...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$130K - $190K *

Drive your career with a dynamic role focused on digital advertising strategy, optimizing B2B client acquisition through Google PPC. Collaborate across teams to enhance performance marketing, leveragi...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$90K - $130K *

Drive business growth by executing strategic sales plans and building client relationships. Leverage industry tools to identify prospects, present solutions, and negotiate contracts while collaboratin...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $120K *

Join a team that's dedicated to driving sales success through strategic planning, team development, and strong leadership. Collaborate with sales reps to achieve goals and foster a positive work envir...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Drive growth by managing strategic accounts, developing new business, and nurturing relationships within your territory. Collaborate with teams to ensure client satisfaction and achieve sales targets...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $95K *

Transform workplace dynamics by managing employee and labor relations, conducting investigations, and ensuring compliance with labor laws. Collaborate with management to foster a fair and productive e...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Staffing

$150K - $180K *

Engage with C-suite leaders to drive strategic sales for a compliance platform. Lead full sales cycles, develop account strategies, and leverage AI tools to enhance client relationships and achieve re...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$109K - $175K *

Champion a pivotal role bridging scientific and commercial teams, driving Spatial Proteomics sales through customer engagement, KOL relationships, and market activation. Leverage scientific expertise...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Take ownership of complex ERP solutions by analyzing business processes, designing customizations, and leading integration efforts to optimize performance and ensure data integrity across systems whil...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$230K - $290K *

Pioneer the future of checkout experiences by leading frontend engineering initiatives. Collaborate across teams to set technical strategies, enhance operational processes, and foster a culture of qua...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$170K - $200K *

Shape the future of finance transformation by prioritizing systems requests and process improvements. Collaborate across teams to enhance operations and drive impactful change in a fast-paced, dynamic...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$235K - $270K *

Join a team that's driving access strategy across the Northeast, managing key payer relationships and ensuring launch readiness for rare disease therapies. Collaborate with cross-functional teams to o...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$90K - $120K *

Deliver exceptional sales performance by managing territory relationships and driving growth through effective product promotion and client engagement in the electrical industry...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$108K - $130K *

Champion the development of Planning and Inventory strategies, leading a team to optimize supply chain performance and ensure compliance. Drive process improvements and manage supplier relationships t...

RemoteRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Lead the charge in optimizing physical therapy operations, enhancing care quality and access through strategic resource allocation and team development. Collaborate across clinical functions to drive...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$200K - $240K *

Unlock potential by leading performance marketing initiatives to drive qualified customer acquisition through innovative digital strategies and collaboration with cross-functional teams...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$200K - $220K *

Innovate high-performance services by collaborating with engineers to design, implement, and optimize scalable systems, ensuring reliability and efficiency in a distributed environment...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$105K - $125K *

Drive your career forward by cultivating relationships and achieving growth in enterprise accounts. Leverage your sales expertise to influence decision-makers and deliver tailored solutions across div...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$186K - $233K *

Shape impactful marketing strategies for lung cancer programs, collaborating with cross-functional teams to drive patient engagement and launch readiness. Lead initiatives that align with brand goals...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Join a team that's driving growth in refinery and petrochemical markets. As a key commercial leader, you'll manage high-value opportunities, negotiate strategic deals, and ensure flawless project deli...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$100K - $120K *

Join a team that's driving innovation in business development, fostering relationships with customers and partners to identify growth opportunities in the chemicals industry while managing the full li...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$203K - $245K *

Unlock potential by leading a national team of Thought Leader Liaisons to enhance KOL engagement and advocacy in oncology. Drive strategic initiatives, foster collaboration, and ensure compliance whil...

RemoteRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Unlock advanced security analytics by leveraging your expertise to enhance incident response capabilities. Collaborate with cross-functional teams to develop scalable solutions and mitigate risks whil...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$82K - $150K *

Drive growth by aggressively prospecting and converting new dental accounts while expanding existing relationships. Leverage a hunter mentality to position value-oriented implant solutions and achieve...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $100K *

Drive your career forward by delivering actionable insights and strategies that enhance client media performance. Collaborate with cross-functional teams to craft compelling narratives and optimize me...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Media

Frequently Asked Questions (FAQ)

  • What South Dakota jobs on Ladders pay $100,000 or more?question toggle

    Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.

  • Which South Dakota cities have high-paying jobs?question toggle

    Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.

  • Are remote jobs available to South Dakota residents?question toggle

    Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.

  • How can I find senior-level jobs in South Dakota?question toggle

    Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.

  • Does Ladders verify South Dakota job listings?question toggle

    Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.