Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.
South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.
Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.
Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.
Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.
Average Salary: $119,100
Regional Account Executive - Ohio (South)
$80K - $95K *
Drive growth by managing strategic accounts, developing new business, and nurturing relationships within your territory. Collaborate with teams to ensure client satisfaction and achieve sales targets...
3 days ago
Labor and Employee Relations Business Partner
$85K - $95K *
Transform workplace dynamics by managing employee and labor relations, conducting investigations, and ensuring compliance with labor laws. Collaborate with management to foster a fair and productive e...
3 days ago
$150K - $180K *
Engage with C-suite leaders to drive strategic sales for a compliance platform. Lead full sales cycles, develop account strategies, and leverage AI tools to enhance client relationships and achieve re...
3 days ago
$109K - $175K *
Champion a pivotal role bridging scientific and commercial teams, driving Spatial Proteomics sales through customer engagement, KOL relationships, and market activation. Leverage scientific expertise...
3 days ago
$110K - $130K *
Take ownership of complex ERP solutions by analyzing business processes, designing customizations, and leading integration efforts to optimize performance and ensure data integrity across systems whil...
3 days ago
Staff Software Engineer, Frontend (Decisions Orechestration)
$230K - $290K *
Pioneer the future of checkout experiences by leading frontend engineering initiatives. Collaborate across teams to set technical strategies, enhance operational processes, and foster a culture of qua...
3 days ago
Senior Manager, Finance Transformation
$170K - $200K *
Shape the future of finance transformation by prioritizing systems requests and process improvements. Collaborate across teams to enhance operations and drive impactful change in a fast-paced, dynamic...
3 days ago
Director, Managed Markets - Regional - Northeast
$235K - $270K *
Join a team that's driving access strategy across the Northeast, managing key payer relationships and ensuring launch readiness for rare disease therapies. Collaborate with cross-functional teams to o...
3 days ago
Territory Sales Manager - Remote - Knoxville, TN
$90K - $120K *
Deliver exceptional sales performance by managing territory relationships and driving growth through effective product promotion and client engagement in the electrical industry...
Reposted 3 days ago
Senior Manager, Supply Chain 1
$108K - $130K *
Champion the development of Planning and Inventory strategies, leading a team to optimize supply chain performance and ensure compliance. Drive process improvements and manage supplier relationships t...
Reposted 3 days ago
Senior Manager, Physical Therapy
$110K - $130K *
Lead the charge in optimizing physical therapy operations, enhancing care quality and access through strategic resource allocation and team development. Collaborate across clinical functions to drive...
3 days ago
Director of Performance Marketing
$200K - $240K *
Unlock potential by leading performance marketing initiatives to drive qualified customer acquisition through innovative digital strategies and collaboration with cross-functional teams...
3 days ago
Staff Software Engineer, Core Services
$200K - $220K *
Innovate high-performance services by collaborating with engineers to design, implement, and optimize scalable systems, ensuring reliability and efficiency in a distributed environment...
3 days ago
Enterprise Growth Account Executive
$105K - $125K *
Drive your career forward by cultivating relationships and achieving growth in enterprise accounts. Leverage your sales expertise to influence decision-makers and deliver tailored solutions across div...
3 days ago
Associate Director, Marketing, Lung Patient
$186K - $233K *
Shape impactful marketing strategies for lung cancer programs, collaborating with cross-functional teams to drive patient engagement and launch readiness. Lead initiatives that align with brand goals...
3 days ago
$110K - $130K *
Join a team that's driving growth in refinery and petrochemical markets. As a key commercial leader, you'll manage high-value opportunities, negotiate strategic deals, and ensure flawless project deli...
Reposted 3 days ago
Business Development Manager Job (Remote (Home Based), Remote (Home Based), United States)
$100K - $120K *
Join a team that's driving innovation in business development, fostering relationships with customers and partners to identify growth opportunities in the chemicals industry while managing the full li...
Reposted 3 days ago
Dir, Thought Leader Liaison (Oncology)
$203K - $245K *
Unlock potential by leading a national team of Thought Leader Liaisons to enhance KOL engagement and advocacy in oncology. Drive strategic initiatives, foster collaboration, and ensure compliance whil...
Reposted 3 days ago
$110K - $130K *
Unlock advanced security analytics by leveraging your expertise to enhance incident response capabilities. Collaborate with cross-functional teams to develop scalable solutions and mitigate risks whil...
Reposted 3 days ago
Territory Sales Representative, Dental Implants MIS
$82K - $150K *
Drive growth by aggressively prospecting and converting new dental accounts while expanding existing relationships. Leverage a hunter mentality to position value-oriented implant solutions and achieve...
Reposted 3 days ago
Client Strategy Manager, Measurement
$90K - $100K *
Drive your career forward by delivering actionable insights and strategies that enhance client media performance. Collaborate with cross-functional teams to craft compelling narratives and optimize me...
3 days ago
Head of Marketing, 0x & Matcha
$200K - $300K *
Join a team that's redefining marketing strategy in the DeFi space. Lead a senior marketing team, drive growth for innovative products, and shape brand narratives while collaborating closely with sale...
3 days ago
Nuclear Fire Protection Engineer
$100K - $120K *
Lead the charge in enhancing fire protection systems for nuclear facilities while collaborating with engineering teams, ensuring compliance with regulations, and supporting modifications that safeguar...
Reposted 3 days ago
Senior Technical Account Manager
$120K - $145K *
Drive customer success by managing the post-sales lifecycle, implementing solutions, and troubleshooting technical issues for strategic clients, ensuring they maximize value from Teleport products and...
3 days ago
$80K - $95K *
Develop and nurture partnerships with school districts to drive product adoption, enhance customer success, and ensure long-term retention through strategic implementation and proactive engagement...
3 days ago
What South Dakota jobs on Ladders pay $100,000 or more?
Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.
Which South Dakota cities have high-paying jobs?
Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.
Are remote jobs available to South Dakota residents?
Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.
How can I find senior-level jobs in South Dakota?
Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.
Does Ladders verify South Dakota job listings?
Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.