Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Senior Growth Marketing Manager, Consumer
$126K - $236K *
Lead the charge in consumer engagement and growth strategy, driving awareness and deepening user connections across channels. Collaborate cross-functionally to optimize campaigns that inspire action a...
3 days ago
Senior AI Engineer, Platform Integration
$135K - $175K *
Drive the integration of AI tools into a secure cloud platform for capital markets, ensuring compliance and security while collaborating with top law firms and engineering teams to enhance document wo...
3 days ago
Enterprise Business Development Manager
$90K - $110K *
Join a team that's driving enterprise growth by building relationships and closing new business. This proactive sales role focuses on acquiring customers for innovative workforce development solutions...
3 days ago
$275K - $340K *
Drive growth by leading sales and customer success teams, refining strategies, and optimizing processes. Shape the commercial landscape while mentoring talent and ensuring high-value customer relation...
3 days ago
Director, Copay & Affordability
$199K - $269K *
Shape patient affordability strategies by leading a dynamic team focused on co-pay programs and innovative solutions. Collaborate cross-functionally to enhance operations, optimize performance, and dr...
Reposted 3 days ago
Director Global Safety- Global Periodic Aggregate Safety Reports
$191K - $258K *
Shape the future of global safety by leading the development and submission of periodic aggregate safety reports. Drive compliance and collaboration across teams while managing a diverse global team t...
3 days ago
$85K - $100K *
Deliver advanced field service support for Promega instrumentation, ensuring installation, training, and repairs meet customer service standards. Collaborate with teams to enhance service documentatio...
3 days ago
Senior Director of Design, Search & Feeds
$317K - $443K *
Engage with cross-functional teams to shape the design vision for search and feeds, leading a talented design group to enhance user discovery and community connections while driving growth and retenti...
3 days ago
$80K - $95K *
Join a team that's dedicated to enhancing automation solutions through troubleshooting, programming, and customer collaboration. Leverage your skills to improve machinery performance and ensure seamle...
Reposted 3 days ago
National Account Director, Community Oncology
$245K - $290K *
Champion strategic relationships in community oncology to enhance market access for innovative therapies. Drive account strategies, negotiate contracts, and collaborate cross-functionally to ensure op...
3 days ago
Sales Solutions Engineer - 1079
$80K - $95K *
Shape the future of client solutions by leading technical discovery and crafting innovative data-driven strategies. Collaborate with sales teams to drive success and ensure seamless implementation of...
3 days ago
AI Deployment Engineer/Manager
$80K - $95K *
Champion the deployment of cutting-edge AI systems in diverse environments. Collaborate with teams to ensure seamless installation and operation of hardware and software, while providing exceptional c...
3 days ago
Supervisory Pharmacist (Clinical)
$100K - $120K *
Elevate pharmacy operations by leading strategic initiatives, ensuring compliance, and managing a skilled team to deliver exceptional patient care and medication management services in a dynamic healt...
Reposted 3 days ago
Supervisory Pharmacist (Clinical)
$100K - $120K *
Join a dynamic team as you oversee pharmacy operations, ensuring compliance and excellence in clinical care. Lead a diverse staff, manage performance, and collaborate effectively for optimal patient o...
Reposted 3 days ago
Senior Director, Alliance Management
$242K - $290K *
Empower strategic partnerships by managing alliances, driving collaboration, and ensuring alignment with organizational goals. Leverage your expertise to foster trust and deliver impactful outcomes in...
3 days ago
Professional Services Engineer - Remote
$110K - $160K *
Optimize customer networks while delivering integrated networking and cybersecurity solutions. Collaborate globally, enhance performance, and ensure satisfaction as you tackle complex challenges in an...
Reposted 3 days ago
Strategic Advertising Account Executive
$138K - $202K *
Drive impactful strategies in enterprise advertising sales, partnering with complex clients to leverage AI and predictive insights for revenue growth. Influence outcomes in a fast-paced environment wh...
Reposted 3 days ago
$100K - $120K *
Lead the monthly close and day-to-day accounting operations, ensuring accuracy and efficiency as the business scales. Collaborate with cross-functional teams to enhance processes and implement automat...
3 days ago
Senior Strategist, Paid Search (DTC)
$85K - $106K *
Empower clients by leading innovative paid search strategies across diverse categories. Collaborate with cross-functional teams to drive performance, optimize campaigns, and connect search tactics to...
3 days ago
$80K - $95K *
Lead the implementation of safety programs across multiple wind and solar project sites, ensuring compliance and promoting a safe work environment for all team members and contractors. Collaborate wit...
Reposted 3 days ago
Territory Manager - Glaucoma - Central
$90K - $140K *
Unlock potential by driving growth and adoption of innovative surgical glaucoma technology. Collaborate with surgeons and staff to deliver exceptional support and education, while building sustainable...
Reposted 3 days ago
21GRAMS- Creative Director, Copy
$200K - $220K *
Drive impactful healthcare advertising by leading creative teams, overseeing brand strategies, and ensuring high-quality copy and art execution. Collaborate across departments to foster innovation and...
3 days ago
Commercial Casualty Supervisor, Complex Claims - Remote
$110K - $147K *
Transform complex claims management by supervising 1st and 3rd party auto and commercial injury claims. Lead a remote team, ensuring compliance and operational excellence while fostering strong relati...
3 days ago
VP OF SALES - EAST COAST - HEALTHCARE
$160K - $200K *
Empower your career by leading a high-performing sales team to drive profitable growth in the healthcare sector. Develop and execute strategic sales initiatives, foster client relationships, and ensur...
Reposted 3 days ago
Senior Account Executive II, Federal DOW/Army/Navy/Air Force/Pentagon
$140K - $175K *
Transform your career by engaging with federal clients, driving enterprise solutions, and building lasting relationships in a dynamic SaaS environment. Leverage your technical expertise to exceed sale...
3 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.