Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Senior Connector Development Engineer
$120K - $145K *
Join a team that's shaping the future of interconnect technology by designing innovative connector solutions. Leverage your engineering expertise to collaborate globally and meet the demands of leadin...
3 days ago
Senior Technical Account Manager (Strategic Alliances)
$146K - $225K *
Unlock potential by owning the operational health of technical accounts, driving integrations, and collaborating across teams to deliver exceptional service and solutions that align with merchant obje...
3 days ago
$94K - $135K *
Shape the future of implementation by leading a dynamic team to ensure successful project execution, stakeholder engagement, and quality outcomes in a fast-paced environment...
Reposted 3 days ago
$100K - $150K *
Transform patient care by leveraging multimodal AI models in a hands-on role. Collaborate with life sciences to innovate solutions, ensuring regulatory compliance while contributing to impactful resea...
3 days ago
MRD Clinical Account Executive, Utah/Wyoming
$100K - $120K *
Champion the adoption of MRD testing services by engaging clinicians and stakeholders, driving strategic business development, and maximizing client relationships within major cancer centers and healt...
3 days ago
$102K - $134K *
Join a team that's redefining project estimating by leading the preparation of competitive bids and cost analyses for electrical construction projects. Collaborate with estimators and suppliers to ens...
3 days ago
Field Service Engineer - Phoenix
$80K - $100K *
Support a diverse team in delivering exceptional field service for high-tech vacuum products. Engage with customers, troubleshoot systems, and ensure operational excellence while traveling for install...
3 days ago
Director of Cloud Team - Remote
$128K - $225K *
Unlock potential by leading cloud engineering strategy and product development. Oversee a high-performing team to deliver secure, scalable cloud solutions across multiple providers, ensuring alignment...
3 days ago
Security Operations Center Analyst II - Remote
$71K - $118K *
Advance your career by analyzing and responding to cyber incidents in a dynamic 24x7 Security Operations Center, supporting U.S. State, Local, Tribal, and Territorial governments with critical securit...
3 days ago
$131K - $209K *
Engage with teams to deliver comprehensive AI enablement programs, designing tailored learning paths and fostering a culture of proficiency across all departments. Collaborate closely with HR to integ...
3 days ago
$125K - $150K *
Elevate HR leadership by driving people strategies that enhance organizational effectiveness and employee engagement across multiple locations in the North America Industrial & Construction sector, pa...
3 days ago
Director, Application & Technical Service
$135K - $160K *
Lead the charge in building a unified technical organization that enhances customer experience through application support and field service, driving project conversions and fostering a culture of con...
3 days ago
Strategic Account Executive - Chicago
$189K - $255K *
Drive strategic sales initiatives by developing account plans, fostering C-level relationships, and leading negotiations to maximize customer success and revenue growth across a diverse product portfo...
3 days ago
Manager, Strategic Client Solutions
$100K - $120K *
Accelerate client relationships by managing strategic accounts, driving revenue growth, and expanding service lines. Collaborate with internal teams to ensure client satisfaction and deliver tailored...
3 days ago
$125K - $150K *
Accelerate account management strategy and execution for premier accounts. Strengthen relationships through planning, product penetration, and high-quality execution while collaborating across teams t...
3 days ago
SERVICENOW CATALOG PRACTICE LEAD
$105K - $163K *
Empower AI seeks to optimize ITSM solutions by leading ServiceNow development for a Department of War agency. Drive high-quality, secure applications while enhancing user experience through Agile meth...
3 days ago
$150K - $160K *
Unlock potential by leading strategic capture efforts for federal opportunities. Drive business development initiatives, engage with customers and partners, and coordinate cross-functional teams to se...
3 days ago
Rail & Transit Territory Sales Manager - GCG Connectivity & Power Solutions - Remote + Travel
$120K - $130K *
Join our dynamic sales team to drive growth in the rail and transit market. Engage with OEMs and engineering teams, providing tailored connectivity solutions while managing strategic accounts across a...
3 days ago
$80K - $95K *
Drive quality assurance initiatives by overseeing inspections, compliance, and documentation processes. Collaborate with suppliers and clients to ensure adherence to standards and enhance operational...
3 days ago
Public Health Analyst I (Vaccines)
$100K - $108K *
Join a dynamic team to provide essential data management and help desk support for public health initiatives, ensuring effective communication and technical assistance for healthcare facilities and us...
3 days ago
Public Health Analyst I (Vaccines)
$100K - $108K *
Unlock potential by providing essential data management and help desk support for public health initiatives, ensuring efficient operations and user assistance in a dynamic healthcare environment...
3 days ago
$90K - $95K *
Accelerate progress at the forefront of multimedia design, creating innovative 3D assets and motion graphics. Collaborate with cross-functional teams to deliver engaging eLearning content while mentor...
3 days ago
Network Security Engineer Master
$125K - $150K *
Empower a robust enterprise network-security infrastructure by leading initiatives in design, operation, and troubleshooting of advanced firewall systems. Collaborate with cross-functional teams to en...
Reposted 3 days ago
Infrastructure Security Team Lead
$143K - $214K *
Oversee and enhance security measures across network, compliance, and access management. Collaborate with teams to design and implement resilient infrastructure while leading a high-performing securit...
3 days ago
$110K - $130K *
Advance your career by leading substation projects, managing design and execution for diverse clients. Collaborate with teams to ensure quality, safety, and efficiency while driving operational improv...
3 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.