Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$170K - $200K *

Lead the national growth strategy in the Government & Military sectors, leveraging $2 trillion in annual spending. This pivotal role will establish Sonepar as the preferred partner in electrical distr...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$145K - $270K *

Elevate your career by leading global executive recruiting efforts, shaping talent strategies, and building high-performing teams. Drive impactful searches and foster relationships with senior leaders...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$72K - $97K *

Empower individuals by coordinating personalized care plans for seniors and members with disabilities. Collaborate with healthcare providers and manage caseloads while enjoying a flexible, remote work...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$350K - $400K *

Optimize enterprise sales growth by leading a high-performing team, refining strategies, and driving revenue. Collaborate across departments to enhance processes and ensure long-term success in a dyna...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$184K - $403K *

Lead the charge in shaping enterprise financial planning, guiding strategic decisions through insightful analyses and robust forecasting. Manage a high-performing team while driving accountability and...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Information Technology

$155K - $217K *

Join a dynamic team to negotiate and close high-profile commercial agreements, supporting various business units while driving growth in a leading SaaS company. Collaborate closely with sales and prod...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Manage project lifecycles from order to delivery, ensuring quality, budget, and customer satisfaction. Collaborate across teams to drive communication and resolve escalations while championing continu...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$150K - $160K *

Develop and execute strategies for deployment options across cloud and self-hosted setups, ensuring compliance and security. Collaborate with cross-functional teams to enhance product offerings and dr...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$84K - $124K *

Transform software solutions by designing, developing, and enhancing applications in an agile environment. Collaborate with teams to deliver high-quality, scalable systems while ensuring transparency...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$120K - $130K *

Manage strategic accounts within the Life Sciences sector, driving growth by cultivating customer relationships and identifying new business opportunities. Leverage industry knowledge to ensure alignm...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$100K - $130K *

Take ownership of sales within a key territory, identifying opportunities and nurturing relationships with clients to drive business growth and exceed sales goals through strategic engagement and effe...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$150K - $180K *

Drive exceptional support experiences globally, leading a high-performing team to enhance operational efficiency and scale offerings as our customer base and product suite expand...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Information Technology

$90K - $130K *

Drive revenue growth by developing strategic sales plans and building client relationships in the dynamic Connected TV advertising landscape. Leverage industry knowledge to identify opportunities and...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$140K - $175K *

Join a dynamic team as you drive renewals and expansion for managed sales customers. Leverage executive relationships and strategic planning to enhance account growth while collaborating with cross-fu...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Media

$96K - $120K *

Champion the growth of SPINNING Systems by leveraging technical expertise, driving sales initiatives, and collaborating across teams to enhance customer engagement and market presence in the life scie...

RemoteRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$96K - $120K *

Pioneer growth and market penetration for advanced SPINNING Systems. Leverage technical expertise to support sales, engage customers, and collaborate cross-functionally, driving innovative solutions a...

RemoteRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$150K - $240K *

Develop innovative PCB layouts and improve product designs by collaborating with cross-functional teams. Ensure high quality and compliance throughout the engineering and manufacturing process, while...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$70K - $94K *

Elevate your career by leading innovative paid media initiatives, optimizing campaigns, and exploring emerging channels to enhance enrollment strategies. Collaborate cross-functionally to drive perfor...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$88K - $105K *

Join a team that accelerates growth in the Electric Utility sector by building robust relationships, driving sales strategies, and expanding market presence across multiple states. Ideal for motivated...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$162K - $185K *

Drive strategic product development to meet growth goals, prioritizing user impact and results while collaborating with cross-functional teams to deliver innovative solutions that resonate with both B...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Transform the cybersecurity landscape by driving revenue growth and building strong customer relationships in the mid-market segment. Leverage consultative selling and AI-driven solutions to engage te...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$90K - $105K *

Tackle medical claims audits in a dynamic remote environment, collaborating with a skilled team to ensure compliance and accuracy in Skilled Nursing Facility reviews while enhancing audit processes an...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$82K - $150K *

Drive growth by aggressively prospecting and converting new dental implant accounts. Leverage a hunter mentality to expand market share, build relationships, and position value-oriented solutions with...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$175K - $200K *

Drive strategic medical initiatives in Rare Neurology, collaborating with cross-functional teams to enhance patient outcomes. Leverage your expertise to shape launch strategies and foster relationship...

RemoteRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$175K - $210K *

Lead the global SIOP process, ensuring synchronization across Sales, Marketing, and Supply Chain functions to optimize inventory and enhance operational efficiency for $1.2B in annual sales. Drive str...

RemoteRemote

Reposted 3 days ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.