Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$70K - $94K *
Elevate your career by leading innovative paid media initiatives, optimizing campaigns, and exploring emerging channels to enhance enrollment strategies. Collaborate cross-functionally to drive perfor...
3 days ago
Territory Manager - Remote (MN/ND/SD)
$88K - $105K *
Join a team that accelerates growth in the Electric Utility sector by building robust relationships, driving sales strategies, and expanding market presence across multiple states. Ideal for motivated...
Reposted 3 days ago
$162K - $185K *
Drive strategic product development to meet growth goals, prioritizing user impact and results while collaborating with cross-functional teams to deliver innovative solutions that resonate with both B...
Reposted 3 days ago
$110K - $130K *
Transform the cybersecurity landscape by driving revenue growth and building strong customer relationships in the mid-market segment. Leverage consultative selling and AI-driven solutions to engage te...
3 days ago
Medical Review Nurse II - SNF/MDS Auditor
$90K - $105K *
Tackle medical claims audits in a dynamic remote environment, collaborating with a skilled team to ensure compliance and accuracy in Skilled Nursing Facility reviews while enhancing audit processes an...
3 days ago
Territory Sales Representative, Implants MIS
$82K - $150K *
Drive growth by aggressively prospecting and converting new dental implant accounts. Leverage a hunter mentality to expand market share, build relationships, and position value-oriented solutions with...
Reposted 3 days ago
Associate Medical Director- Rare Neuro
$175K - $200K *
Drive strategic medical initiatives in Rare Neurology, collaborating with cross-functional teams to enhance patient outcomes. Leverage your expertise to shape launch strategies and foster relationship...
Reposted 3 days ago
VP, Global Sales, Inventory & Operations Planning
$175K - $210K *
Lead the global SIOP process, ensuring synchronization across Sales, Marketing, and Supply Chain functions to optimize inventory and enhance operational efficiency for $1.2B in annual sales. Drive str...
Reposted 3 days ago
$140K - $175K *
Shape technical innovation by leading cross-team efforts in system architecture and development. Drive scalable improvements, mentor peers, and influence business outcomes while ensuring long-term mai...
3 days ago
$300K - $500K *
Champion innovation by architecting and developing high-performance, real-time trading web apps. Leverage your expertise to enhance user experience and drive product evolution in a dynamic, collaborat...
3 days ago
$64K - $102K *
Elevate network performance by deploying and optimizing voice solutions, ensuring 99.999% uptime. Collaborate on network planning and security, while providing expert support and documentation for com...
Reposted 3 days ago
$60K - $120K *
Empower growth by engaging existing customers, identifying upgrade opportunities, and managing the full sales cycle. Build trust with small business owners while driving revenue through effective outr...
3 days ago
Staff, Product Manager - Identity
$155K - $228K *
Join a team that's shaping the future of identity products, delivering secure, developer-first experiences. Collaborate with leadership to build innovative solutions that empower customers and enhance...
3 days ago
Account Executive - North America New Logo
$140K - $220K *
Join a dynamic team focused on driving new business growth through strategic sales initiatives. Engage with key decision-makers, execute impactful presentations, and leverage multi-channel outreach to...
3 days ago
Regulatory Affairs Director (Remote - United States)
$211K - $290K *
Champion global regulatory strategies to drive product approvals and market access for innovative dental solutions. Collaborate with cross-functional teams to navigate complex regulatory landscapes an...
3 days ago
Affiliate Marketing Manager - US, Remote
$85K - $144K *
Take ownership of the North America affiliate channel by driving strategy, measuring performance, and fostering growth while leading a team and optimizing partnerships for maximum profitability...
Reposted 3 days ago
Senior Staff Frontend Engineer
$150K - $180K *
Join us to architect a unified web platform that enhances user experience across multiple services. Lead front-end development, optimize performance, and mentor engineers while ensuring seamless integ...
3 days ago
$110K - $130K *
Manage the full sales cycle to open new mid-market and enterprise accounts, develop cross-sell opportunities, and grow customer relationships through high-value cybersecurity services, ensuring commer...
Reposted 3 days ago
$90K - $110K *
Empower strategic growth by managing key accounts across diverse sectors. Drive revenue, enhance client relationships, and deliver integrated solutions while collaborating with global teams to ensure...
Reposted 3 days ago
Customer Care Center Trainer - Remote U.S/CAN
$72K - $90K *
Empower our contact center teams by developing and delivering impactful training programs. Drive performance improvement and enhance patient experiences through effective coaching and collaboration wi...
Reposted 3 days ago
$74K - $95K *
Advance operational excellence by leading nationwide store audits, ensuring compliance, identifying risks, and driving continuous improvement in collaboration with cross-functional teams to enhance pe...
Reposted 3 days ago
Manager, Regional Sales - Glaucoma - Central
$160K - $200K *
Shape the future of ophthalmic surgery by leading a high-performing sales team, driving market adoption, and delivering exceptional results in a dynamic environment. Your leadership will cultivate tal...
Reposted 3 days ago
Associate Ocular Sales Representative - West
$90K - $115K *
Join a team that's shaping the future of ocular sales through a dynamic development program. Collaborate with experts, engage healthcare providers, and drive business growth while gaining invaluable e...
Reposted 3 days ago
$100K - $130K *
Champion the delivery of data and AI initiatives by engaging stakeholders and technical teams. Drive strategy and execution while ensuring alignment between business objectives and scalable technology...
Reposted 3 days ago
Strategic Alliance & Channel Manager
$130K - $170K *
Lead the charge in developing strategic partnerships and channel programs to drive revenue growth through effective collaboration and influence. Foster relationships, remove obstacles, and ensure seam...
Reposted 3 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.