Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$245K - $290K *

Champion strategic relationships in community oncology to enhance market access for innovative therapies. Drive account strategies, negotiate contracts, and collaborate cross-functionally to ensure op...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Shape the future of client solutions by leading technical discovery and crafting innovative data-driven strategies. Collaborate with sales teams to drive success and ensure seamless implementation of...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Technical Services

$80K - $95K *

Champion the deployment of cutting-edge AI systems in diverse environments. Collaborate with teams to ensure seamless installation and operation of hardware and software, while providing exceptional c...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $120K *

Elevate pharmacy operations by leading strategic initiatives, ensuring compliance, and managing a skilled team to deliver exceptional patient care and medication management services in a dynamic healt...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Join a dynamic team as you oversee pharmacy operations, ensuring compliance and excellence in clinical care. Lead a diverse staff, manage performance, and collaborate effectively for optimal patient o...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$242K - $290K *

Empower strategic partnerships by managing alliances, driving collaboration, and ensuring alignment with organizational goals. Leverage your expertise to foster trust and deliver impactful outcomes in...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $160K *

Optimize customer networks while delivering integrated networking and cybersecurity solutions. Collaborate globally, enhance performance, and ensure satisfaction as you tackle complex challenges in an...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$138K - $202K *

Drive impactful strategies in enterprise advertising sales, partnering with complex clients to leverage AI and predictive insights for revenue growth. Influence outcomes in a fast-paced environment wh...

United StatesRemote

Reposted 3 days ago

  •   11 - 15 years exp.  •   Information Technology

$100K - $120K *

Lead the monthly close and day-to-day accounting operations, ensuring accuracy and efficiency as the business scales. Collaborate with cross-functional teams to enhance processes and implement automat...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$85K - $106K *

Empower clients by leading innovative paid search strategies across diverse categories. Collaborate with cross-functional teams to drive performance, optimize campaigns, and connect search tactics to...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Lead the implementation of safety programs across multiple wind and solar project sites, ensuring compliance and promoting a safe work environment for all team members and contractors. Collaborate wit...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$90K - $140K *

Unlock potential by driving growth and adoption of innovative surgical glaucoma technology. Collaborate with surgeons and staff to deliver exceptional support and education, while building sustainable...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Healthcare

$200K - $220K *

Drive impactful healthcare advertising by leading creative teams, overseeing brand strategies, and ensuring high-quality copy and art execution. Collaborate across departments to foster innovation and...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $147K *

Transform complex claims management by supervising 1st and 3rd party auto and commercial injury claims. Lead a remote team, ensuring compliance and operational excellence while fostering strong relati...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$160K - $200K *

Empower your career by leading a high-performing sales team to drive profitable growth in the healthcare sector. Develop and execute strategic sales initiatives, foster client relationships, and ensur...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$140K - $175K *

Transform your career by engaging with federal clients, driving enterprise solutions, and building lasting relationships in a dynamic SaaS environment. Leverage your technical expertise to exceed sale...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$180K - $220K *

Optimize revenue and profitability as you lead commercial finance, drive pricing strategies, and negotiate pivotal agreements with stakeholders, playing a vital role in shaping financial success acros...

RemoteRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Information Technology

$239K - $298K *

Discover a pivotal role in shaping the future of our engineering function. Lead a small team to enhance our GTM engine, integrating product and marketing efforts while driving innovation in technology...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$225K - $250K *

Lead the charge in pioneering technology strategies that enhance operational excellence and drive innovation across multiple business units. Partner with leaders to implement advanced solutions in AI...

RemoteRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$110K - $145K *

Partner with us to drive sales growth and elevate client relationships. Utilize tailored product demos and consultative techniques to enhance customer satisfaction and revenue, while leveraging your e...

RemoteRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Join a team that's building the Keycard Agent SDK to empower developers by enhancing trust, governance, and telemetry for AI agents. Collaborate on innovative solutions across multiple languages and f...

RemoteRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Information Technology

$139K - $235K *

Lead the charge in transforming investor relations processes, enhancing communication of strategy and performance to the market. Collaborate with executives to manage investor relationships and delive...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$222K - $278K *

Join a dynamic team to drive enterprise sales, transforming industries through innovative technology. Engage with C-level executives, manage complex deals, and foster lasting relationships to enhance...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $180K *

Elevate your career by driving sales in the U.S. healthcare market, engaging diverse stakeholders, and managing complex sales cycles to expand our national brain-network footprint through strategic pa...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $300K *

Lead complex analytical initiatives by developing data solutions and dashboards that drive business insights. Collaborate with stakeholders to translate requirements into scalable analytical framework...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.