Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$116K - $170K *

Join a dynamic team to drive the planning and execution of PLC updates, ensuring seamless operations across automated warehouse sites while coordinating with cross-functional partners and enhancing de...

United StatesRemote

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  •   5 - 7 years exp.  •   Manufacturing & Automotive

$119K - $190K *

Deliver strategic growth in the Oil & Gas and Chemical sectors by identifying opportunities, building executive relationships, and enabling sales. Leverage industry expertise to shape market strategie...

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  •   5 - 7 years exp.  •   Manufacturing & Automotive

$78K - $103K *

Join a dynamic team to perform complex coding reviews in Radiation Oncology. Leverage your expertise in CPT, HCPCS, and ICD-10 to resolve errors and ensure accurate billing. This remote role offers a...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$80K - $130K *

Lead dealership implementations by managing go-lives, training teams, and ensuring seamless integrations. Collaborate with stakeholders to optimize workflows and drive adoption, while traveling freque...

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  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Advance global clinical trials by leading cross-functional teams, ensuring compliance and operational excellence while managing timelines and budgets to deliver impactful results in Oncology research...

United StatesRemote

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  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead complex, cross-functional initiatives by providing senior-level project and program expertise. Drive planning, implementation, and continuous improvement of health informatics processes and syste...

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  •   8 - 10 years exp.  •   Information Technology

$117K - $161K *

Innovate and drive sales growth by securing new business opportunities in the aerospace and defense sectors, focusing on advanced motion control solutions for UAVs and other defense platforms while bu...

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  •   Less than 5 years exp.  •   Manufacturing & Automotive

$149K - $170K *

Unlock potential by leading enterprise vulnerability management and cybersecurity initiatives. Drive compliance, risk mitigation, and modernization efforts across diverse technical domains to enhance...

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  •   8 - 10 years exp.  •   Information Technology

$135K *

Elevate client success by leading innovative training programs that enhance learning experiences. Drive product adoption and satisfaction through tailored onboarding and ongoing education, ensuring cl...

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  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $115K *

Join a team that's dedicated to enhancing customer success in cybersecurity. Leverage your expertise to build trusted relationships, drive product adoption, and ensure client satisfaction while naviga...

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  •   Less than 5 years exp.  •   Consumer Technology

$64K - $173K *

Accelerate your career by developing innovative digital solutions that enhance customer experiences. Collaborate with cross-functional teams to design, code, and deploy high-quality software applicati...

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Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$92K - $166K *

Pioneer your career in transmission engineering, leading major EPC projects while driving innovation and technology development. Shape processes and tools that enhance project delivery and client sati...

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  •   8 - 10 years exp.  •   Technical Services

$67K - $199K *

Empower operational excellence by leading provider data governance and attribution processes. Collaborate across departments to ensure data integrity, enhance reporting accuracy, and drive continuous...

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  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $227K *

Unlock potential by driving customer success through strategic product insights and collaboration. Leverage your expertise to enhance product adoption and quality, ensuring a seamless experience acros...

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  •   8 - 10 years exp.  •   Enterprise Technology

$105K - $127K *

Champion transformative patient experience strategies by leveraging data insights to drive high-impact initiatives. Collaborate with C-suite executives and healthcare providers to enhance operational...

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  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Lead and advance the Operations Quality Assurance program, establishing standards and leveraging analytics and AI to drive performance improvements across teams while fostering talent development and...

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$180K - $220K *

Unlock potential by driving strategic partnerships that embed data solutions into non-pharma markets. This high-impact role requires a blend of business development and relationship management to crea...

United StatesRemote

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  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$172K - $215K *

Drive the execution of solar construction projects by leading a skilled team, ensuring compliance with safety standards, and optimizing drilling operations for stable foundations. Collaborate with sta...

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  •   5 - 7 years exp.  •   Energy & Utilities

$80K - $100K *

Partner with us to enhance client relationships and optimize account management. Drive operational strategies, support sales pursuits, and collaborate with leaders to improve performance and transpare...

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  •   Less than 5 years exp.  •   Business Services

$78K - $131K *

Inspire growth by partnering with leaders to design impactful learning experiences that enhance performance across teams. Drive initiatives that empower employees to achieve their goals and improve pr...

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  •   Less than 5 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Join a team that's dedicated to enhancing technical enablement for sales and engineering roles. You'll develop scalable training programs, manage onboarding, and create hands-on resources to ensure fl...

United StatesRemote

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  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Partner with us to deliver tailored solutions and in-depth demos, supporting a dynamic sales pipeline. Leverage your technical expertise to drive customer success and collaborate with teams to enhance...

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  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $95K *

Drive the design, build, testing, and support of applications, ensuring optimal functionality and user satisfaction while collaborating with interdisciplinary teams to enhance workflows and resolve co...

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  •   Less than 5 years exp.  •   Healthcare

$119K - $190K *

Champion ABB's growth in the Pharmaceutical & Biotechnology sector by developing strategies, building executive relationships, and identifying market opportunities to drive sales and enhance customer...

United StatesRemote

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  •   8 - 10 years exp.  •   Manufacturing & Automotive

$82K - $182K *

Lead strategic initiatives by connecting technology investments to business goals, ensuring effective governance and measurable outcomes. Collaborate cross-functionally to enhance operational efficien...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.