Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$135K - $160K *
Engage in designing and optimizing AI solutions to enhance automation and analytics, collaborating across teams to integrate advanced AI capabilities into core products, while ensuring ethical standar...
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Associate Director, Quality and Standards Pharmacist
$132K - $213K *
Join a team that's dedicated to maintaining high standards in pharmacy operations. Collaborate with cross-functional teams to ensure quality and compliance in prescription verification, enhancing pati...
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Regulatory RIM Business Analyst & Managed Services Consultant
$100K - $120K *
Transform regulatory environments by configuring and supporting Veeva Vault RIM systems. Collaborate with clients to ensure compliance and reliability while implementing ongoing managed services and a...
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Lead Product Manager- Quote Management (CPQ)
$129K - $186K *
Join a team that's redefining enterprise solutions by leading product strategy and execution for Quote Management. Collaborate across teams to deliver AI-powered tools that enhance sales processes and...
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Executive Engagement Program Specialist
$74K - $105K *
Shape high-impact executive engagement programs by coordinating logistics, timelines, and communications. Drive seamless execution of 10-20 events annually, ensuring polished delivery and stakeholder...
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Senior Technology & Systems Consultant
$130K *
Join a dynamic team to manage client technologies, mentor peers, and deliver IT assessments. This hands-on role emphasizes client service and consultant development, ensuring optimal performance acros...
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$76K - $96K *
Elevate client success by leading national media investments across diverse channels. Drive performance through strategic planning, negotiation, and data analysis while collaborating with cross-functi...
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$94K - $131K *
Join a team that's transforming manufacturing solutions through SAP expertise. Collaborate with clients to implement and optimize SAP ME and S/4 HANA systems, enhancing production efficiency and drivi...
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$130K - $150K *
Take ownership of transformative AI solutions by embedding within business units, identifying key operational challenges, and rapidly delivering demonstrable results that drive adoption and innovation...
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$84K - $106K *
Drive impactful digital video strategies and optimize campaigns across programmatic and direct publisher environments, focusing on CTV and streaming. Collaborate with cross-functional teams to enhance...
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$150K - $180K *
Drive growth and strategy by managing sales teams and client relationships, overseeing performance, and developing talent. Lead initiatives to enhance client engagement and achieve financial targets a...
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Director of Customer Service Operations
$150K - $175K *
Unlock your potential as a hands-on leader in customer service operations, driving performance and quality across teams. Collaborate with cross-functional partners to enhance processes and empower you...
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$120K - $160K *
Contribute to malaria programming by providing technical leadership and support to country teams, ensuring quality interventions, compliance, and strategic resource investments across health facilitie...
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Mainframe System / Network Architect (z/OS) | Remote | 6+ Months
$125K - $150K *
Join a dynamic team to manage and optimize enterprise mainframe environments, ensuring high availability and performance. Collaborate with cross-functional teams on strategic initiatives, system upgra...
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Senior Data Engineer - PostgreSQL and MongoDB
$92K - $203K *
Drive the design and support of a near real-time transactional cache platform, enabling seamless data access for APIs and applications. Collaborate with cross-functional teams to optimize data flows a...
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eHealth Exchange Onboarding Program Manager
$100K - $120K *
Unlock potential by guiding health systems through the eHealth Exchange onboarding process. Ensure seamless implementation, provide exceptional customer service, and enhance interoperability in health...
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Manager of Account Management, Large Group Segment - Cigna Global Health Benefits (GHB) - Remote
$110K - $130K *
Develop strategic leadership for a team managing complex client portfolios, driving retention, growth, and client experience objectives while fostering strong relationships with stakeholders and ensur...
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Director, HRIS & HR Transformation
$160K - $180K *
Drive the transformation of HR operations by leading UKG Pro implementation, optimizing processes, and enhancing analytics capabilities across a multi-state environment, ensuring seamless employee lif...
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Bodily Injury Claims Team Lead
$90K - $110K *
Transform the future of claims management by leading a remote team in commercial transportation. Drive operational effectiveness through technology and analytics while balancing leadership and hands-o...
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$100K - $150K *
Lead the charge in managing complex, technically sophisticated projects, focusing on data centers. Collaborate with diverse stakeholders to ensure project alignment with client goals, budgets, and sch...
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Account Specialist (Toledo, OH)
$160K - $192K *
Transform healthcare engagement by driving commercial performance and building strong relationships with providers. Collaborate cross-functionally to support product launches and ensure patient access...
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Program Manager - Federal Financial / Regulatory Service
$105K - $150K *
Inspire impactful change by leading complex federal digital services programs. Oversee strategy, execution, and customer relationships while managing multidisciplinary teams to deliver high-quality te...
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Senior Software Engineer - Full Stack (Ruby on Rails)
$120K - $135K *
Join a team that's shaping the future of digital services for Veterans. As a Senior Software Engineer, you'll design and maintain scalable applications, collaborate with cross-functional teams, and me...
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Engineer Lead (Library of Congress)
$175K - $195K *
Lead the charge in shaping technical direction and mentoring teams while driving program delivery and fostering a culture of growth and collaboration in a dynamic engineering environment...
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$160K - $200K *
Shape the future of risk management by owning the firm’s exposure landscape. Engage directly with the principal to ensure alignment with current views, maintain thesis hygiene, and define essential da...
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What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.