Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$95K - $115K *

Unlock potential by serving as a trusted HR partner, delivering expert guidance and enhancing employee lifecycle experiences. Collaborate with leaders to drive performance and process improvements whi...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$120K - $130K *

Champion the modernization of data processes by designing and maintaining robust data pipelines in Azure. Collaborate with stakeholders to ensure accurate data integration and support enterprise data...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$145K - $160K *

Accelerate product development by managing the software lifecycle, collaborating with cross-functional teams, and driving strategic initiatives to enhance user experience and meet stakeholder needs...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$175K - $190K *

Lead the charge in managing the software development lifecycle for innovative products, leveraging low-code platforms to enhance user experience and drive strategic initiatives across cross-functional...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Information Technology

$85K - $95K *

Shape the future of supply chain management by driving compliance and efficiency in procurement processes. Collaborate with cross-functional teams to support government contracting activities and ensu...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$110K - $125K *

Elevate product strategy and delivery by leading a multidisciplinary team to ensure alignment with stakeholder needs and mission-critical outcomes in a fully remote environment...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$69K - $99K *

Unlock growth by driving sales across academic, medical, and corporate markets. Build relationships, manage opportunities, and collaborate with teams to exceed targets and enhance customer satisfactio...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Business Services

$110K - $130K *

Champion financial strategy by leading a team of analysts to drive performance, support key decisions, and enhance operational efficiency through insightful reporting and collaboration with senior exe...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Energy & Utilities

$100K - $120K *

Deliver impactful talent development strategies to enhance onboarding, training, and leadership readiness across a diverse, multi-entity workforce. Lead program design and execution while fostering em...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Transportation

$79K - $122K *

Shape the future of IT capabilities by leading requirements analysis and advisory support for a Department of War agency. Collaborate with stakeholders to deliver data-driven insights and enhance ente...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $125K *

Join a team that's redefining sales excellence by engaging customers at national events. You'll develop accounts, provide exceptional service, and stay ahead of technology trends while enjoying uncapp...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$80K - $125K *

Join a dynamic team as you engage customers at national events, providing tailored wireless solutions. Leverage your bilingual skills to enhance customer experiences and drive sales in a fast-paced, r...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$135K - $165K *

Pioneer operational excellence in Design leadership, managing workflows, prioritizing projects, and developing talent. Collaborate cross-functionally to enhance Design integration in AI-driven product...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$77K - $92K *

Collaborate with cross-functional teams to develop innovative healthcare analytics applications, ensuring high-quality solutions that drive performance and value for clients in a dynamic, fast-paced e...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$142K - $168K *

Transform client experiences by leveraging deep expertise in healthcare solutions. Lead strategic initiatives, enhance client relationships, and drive impactful outcomes for high-value accounts throug...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Healthcare

$86K - $113K *

Engage with clients as a trusted partner, driving satisfaction and growth through effective management of healthcare operations and strategic initiatives. Collaborate across teams to enhance service d...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$180K - $220K *

Empower innovation in clinical trials by developing strategies, overseeing operations, and cultivating partnerships. Drive excellence in research, enhance compliance, and manage a high-performing team...

RemoteRemote

Reposted today

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Join us in shaping the future of maternal and newborn health by leading innovative strategies in commodity financing and procurement. Drive impactful change at global and country levels to ensure esse...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$209K - $273K *

Drive innovation by owning customer-facing products end to end, leading technical strategy, and shaping product direction. Collaborate across teams to build AI-native experiences that enhance user eng...

RemoteRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$115K - $125K *

Drive a vibrant EHS culture through strategic leadership and collaboration. Empower stakeholders with expert guidance, ensure compliance, and elevate safety standards across all operations in a dynami...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Transportation

$66K - $99K *

Unlock potential by providing compassionate care to individuals facing substance use and mental health challenges. Join a dedicated team committed to making a difference in the community through excep...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$100K - $125K *

Lead innovative design solutions as a Senior Design Engineer, transforming client needs into actionable broadcast system designs. Collaborate with global teams, mentor junior engineers, and ensure pro...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Hospitality & Recreation

$205K - $240K *

Shape the future of supply chain technology by leading engineering teams in optimizing platforms for logistics and order management. Drive innovation and efficiency while managing a diverse team of ex...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$90K - $120K *

Join a team that's driving innovation in AI and automation solutions across retail. Collaborate with cross-functional teams to develop, deploy, and support enterprise-level applications that enhance m...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$107K - $144K *

Manage tax compliance engagements, ensuring timely service and proactive client communication. Lead a team, review tax work, and maintain expertise in high net worth individual tax matters while drivi...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Legal & Accounting

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.